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This profile was last updated on 1/31/14  and contains information from public web pages and contributions from the ZoomInfo community.

Staff Scientist Vice President

National Institute of Allergy and Infectious Diseases
6610 Rockledge Dr. Room 4800
Bethesda, Maryland 20892
United States

Company Description: NIAID conducts and supports research-at the US National Institutes of Health, throughout the United States, and worldwide-to study the causes of infectious and...   more
Background

Employment History

  • Laboratory of Immunoregulation
    National Institute of Allergy and Infectious Diseases
  • Head of the B Cell HIV Unit In the Immunopathogenesis Section
    NIAID Laboratory of Immunoregulation
  • Head of the B Cell HIV Unit In the Section of the NIAID Laboratory of Immunoregulation
    Immunopathogenesis
  • Member, Section
    Immunopathogenesis
  • Associate Scientist, Immunopathogenesis Section, Laboratory
    Immunoregulation
  • Staff Scientist, NIAID Laboratory
    Immunoregulation

Education

  • Ph.D.
20 Total References
Web References
B Cells Gone Bad: Researchers Uncover How HIV Causes Abnormalities In Antibody-Producing Cells
www.sciencedaily.com, 9 Sept 2004 [cached]
Now, writing in the Sept. 7 online edition of The Journal of Experimental Medicine, Dr. Fauci, Susan Moir, Ph.D., Angela Malaspina, Ph.D., and their colleagues identify a number of pathways that HIV activates to damage or destroy B cells.
...
"Our findings further illuminate the insidious nature of HIV," notes Dr. Moir, head of the B Cell HIV Unit in the Immunopathogenesis Section of the NIAID Laboratory of Immunoregulation (LIR).
...
In their experiments, Drs. Fauci and Moir and their LIR colleagues, in collaboration with scientists from Human Genome Sciences (Rockville, MD), set out to uncover what drives B-cell abnormalities in HIV infection.Using gene chip technology developed by Human Genome Sciences, they probed thousands of genes taken from B cells of HIV-infected patients.The researchers compared which genes were "turned on," or expressed, in the patients whose viral burden was high with profiles of gene expression in patients whose virus was controlled by antiretroviral therapy.The research team also examined gene expression in healthy HIV-negative individuals.
"We found more than 40 genes that were ‘over-expressed' in the group with high HIV levels compared with the two other groups," says Dr. Moir.Most of these genes, she notes, belong to either one of two major physiologic pathways.
...
Dr. Moir and her team discovered that B cells of patients with high levels of HIV have reduced levels of BAFF-R on their surfaces, making these B cells more susceptible to cell death.
Basic Research Archives - Fall 04
www.mihivnews.com, 31 May 2001 [cached]
Now, writing in the Sept. 7 online edition of The Journal of Experimental Medicine, Dr. Fauci, Susan Moir, Ph.D., Angela Malaspina, Ph.D., and their colleagues identify a number of pathways that HIV activates to damage or destroy B cells.
...
Now, writing in the Sept. 7 online edition of The Journal of Experimental Medicine, Dr. Fauci, Susan Moir, Ph.D., Angela Malaspina, Ph.D., and their colleagues identify a number of pathways that HIV activates to damage or destroy B cells.
...
"Our findings further illuminate the insidious nature of HIV," notes Dr. Moir, head of the B Cell HIV Unit in the Immunopathogenesis Section of the NIAID Laboratory of Immunoregulation (LIR).
...
In their experiments, Drs. Fauci and Moir and their LIR colleagues, in collaboration with scientists from Human Genome Sciences (Rockville, MD), set out to uncover what drives B-cell abnormalities in HIV infection.Using gene chip technology developed by Human Genome Sciences, they probed thousands of genes taken from B cells of HIV-infected patients.The researchers compared which genes were "turned on," or expressed, in the patients whose viral burden was high with profiles of gene expression in patients whose virus was controlled by antiretroviral therapy.The research team also examined gene expression in healthy HIV-negative individuals.
"We found more than 40 genes that were 'over-expressed' in the group with high HIV levels compared with the two other groups," says Dr. Moir.Most of these genes, she notes, belong to either one of two major physiologic pathways.
...
Dr. Moir and her team discovered that B cells of patients with high levels of HIV have reduced levels of BAFF-R on their surfaces, making these B cells more susceptible to cell death.
NIH Scientists Reactivate Immune Cells Exhausted by Chronic HIV | Positively Positive
www.positivelypositive.ca, 3 June 2011 [cached]
Scientists from the NIAID Laboratory of Immunoregulation led by Lela Kardava, Ph.D., Susan Moir, Ph.D., and Anthony S. Fauci, M.D., NIAID Director and Chief of the laboratory, wanted to know if this phenomenon can help explain why B cells become "exhausted" and essentially shut down in people who are HIV-infected but treatment-naive.
...
Anthony S. Fauci, M.D., NIAID Director and Chief, NIAID Laboratory of Immunoregulation; and Susan Moir, Ph.D., Staff Scientist, NIAID Laboratory of Immunoregulation, are available to comment on this article.
Antibody Engineering Agenda - Antibody Engineering & Antibody Therapeutics - IBC Life Sciences
www.ibclifesciences.com, 6 Mar 2009 [cached]
Susan Moir, Ph.D., Associate Scientist, Immunopathogenesis Section, Laboratory of Immunoregulation, NIAID/NIH
Susan Moir, Ph.D. - ...
www.vgtifl.org [cached]
Susan Moir, Ph.D. - National Institute of Allergy and Infectious Disease
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