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Room 4089 6610 Rockledge Drive, MSC 6603
Bethesda, Maryland 20892
About the National Institute of Allergy and Infectious Diseases (NIAID) NIAID conducts and supports research - at the National Institutes of Health, throughout the United States, and worldwide - to study the causes of infectious and immune-mediated dise ... more
Associate Scientist, Immunopathogenesis Section, Laboratory
Head of the B Cell HIV Unit In the Section of the NIAID Laboratory of Immunoregulation
View this article at: http://www.jci.org/articles/view/74351?key=97bbd7f61e344de76f06
Susan Moir and colleagues, at the National Institutes of Health, Bethesda, have now found that downregulating the expression of any one of 9 known and putative B cell inhibitory cell-surface proteins on exhausted B cells from individuals infected with HIV enhanced their in vitro proliferation and function. Moir and colleagues therefore suggest that strategies aimed at reversing the effects of inhibitory cell-surface proteins may enhance immune responses in individuals infected with HIV. As exhausted B cells are also found in individuals infected with other persisting viruses, this approach might also be of benefit for these individuals.TITLE: Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors AUTHOR CONTACT:
NIH Scientists Find More Health Benefits From Starting HIV Treatment - Printer Friendly Page - HIV in the News - HealthHIV
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