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This profile was last updated on 2/2/15  and contains information from public web pages and contributions from the ZoomInfo community.

Staff Scientist Vice President

National Institute of Allergy and Infectious Diseases
6610 Rockledge Dr. Room 4800
Bethesda , Maryland 20892
United States

Company Description: The National Institute of Allergy and Infectious Diseases (NIAID) conducts and supports research - at the National Institutes of Health (NIH), throughout the United...   more
Background

Employment History

  • Laboratory of Immunoregulation
    National Institute of Allergy and Infectious Diseases
  • Head of the B Cell HIV Unit In the Immunopathogenesis Section
    NIAID Laboratory of Immunoregulation
  • Head of the B Cell HIV Unit In the Section of the NIAID Laboratory of Immunoregulation
    Immunopathogenesis
  • Member, Section
    Immunopathogenesis

Education

  • Ph.D.
20 Total References
Web References
B Cells Gone Bad: Researchers Uncover How HIV Causes Abnormalities In Antibody-Producing Cells
www.sciencedaily.com, 9 Sept 2004 [cached]
Now, writing in the Sept. 7 online edition of The Journal of Experimental Medicine, Dr. Fauci, Susan Moir, Ph.D., Angela Malaspina, Ph.D., and their colleagues identify a number of pathways that HIV activates to damage or destroy B cells.
...
"Our findings further illuminate the insidious nature of HIV," notes Dr. Moir, head of the B Cell HIV Unit in the Immunopathogenesis Section of the NIAID Laboratory of Immunoregulation (LIR).
...
In their experiments, Drs. Fauci and Moir and their LIR colleagues, in collaboration with scientists from Human Genome Sciences (Rockville, MD), set out to uncover what drives B-cell abnormalities in HIV infection.Using gene chip technology developed by Human Genome Sciences, they probed thousands of genes taken from B cells of HIV-infected patients.The researchers compared which genes were "turned on," or expressed, in the patients whose viral burden was high with profiles of gene expression in patients whose virus was controlled by antiretroviral therapy.The research team also examined gene expression in healthy HIV-negative individuals.
"We found more than 40 genes that were ‘over-expressed' in the group with high HIV levels compared with the two other groups," says Dr. Moir.Most of these genes, she notes, belong to either one of two major physiologic pathways.
...
Dr. Moir and her team discovered that B cells of patients with high levels of HIV have reduced levels of BAFF-R on their surfaces, making these B cells more susceptible to cell death.
Basic Research Archives - Fall 04
www.mihivnews.com, 31 May 2001 [cached]
Now, writing in the Sept. 7 online edition of The Journal of Experimental Medicine, Dr. Fauci, Susan Moir, Ph.D., Angela Malaspina, Ph.D., and their colleagues identify a number of pathways that HIV activates to damage or destroy B cells.
...
Now, writing in the Sept. 7 online edition of The Journal of Experimental Medicine, Dr. Fauci, Susan Moir, Ph.D., Angela Malaspina, Ph.D., and their colleagues identify a number of pathways that HIV activates to damage or destroy B cells.
...
"Our findings further illuminate the insidious nature of HIV," notes Dr. Moir, head of the B Cell HIV Unit in the Immunopathogenesis Section of the NIAID Laboratory of Immunoregulation (LIR).
...
In their experiments, Drs. Fauci and Moir and their LIR colleagues, in collaboration with scientists from Human Genome Sciences (Rockville, MD), set out to uncover what drives B-cell abnormalities in HIV infection.Using gene chip technology developed by Human Genome Sciences, they probed thousands of genes taken from B cells of HIV-infected patients.The researchers compared which genes were "turned on," or expressed, in the patients whose viral burden was high with profiles of gene expression in patients whose virus was controlled by antiretroviral therapy.The research team also examined gene expression in healthy HIV-negative individuals.
"We found more than 40 genes that were 'over-expressed' in the group with high HIV levels compared with the two other groups," says Dr. Moir.Most of these genes, she notes, belong to either one of two major physiologic pathways.
...
Dr. Moir and her team discovered that B cells of patients with high levels of HIV have reduced levels of BAFF-R on their surfaces, making these B cells more susceptible to cell death.
Susan Moir, Ph.D. - ...
www.vgtifl.org, 27 Sept 2013 [cached]
Susan Moir, Ph.D. - National Institute of Allergy and Infectious Disease
Susan Moir, PhD, of the ...
www.poz.com [cached]
Susan Moir, PhD, of the National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, Maryland, and her colleagues sought to determine whether antiretroviral therapy would cause the proportion of B cells to return to normal levels and thus signal a restoration of the immune system.
Moir's team enrolled 29 HIV-positive people who were ready to start antiretroviral therapy.Eighty percent were men, and they were matched with 34 HIV-negative participants who served as a control group.Measurements of immune cells were taken at baselineâ€"the start of the studyâ€"and at three, six and 12 months after the HIV-positive participants started antiretroviral thereapy.
Of the 29 HIV-positive participants, 24 ultimately had measurements of immune cells available from all time points.Moir's team found that the number of B cells overall increased by the 12th month following the start of antiretroviral therapy.
Antibody Engineering Agenda - Antibody Engineering & Antibody Therapeutics - IBC Life Sciences
www.ibclifesciences.com, 6 Mar 2009 [cached]
Susan Moir, Ph.D., Associate Scientist, Immunopathogenesis Section, Laboratory of Immunoregulation, NIAID/NIH
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