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Staff Scientist Vice President
Associate Scientist, Immunopathogenesis Section, Laboratory
Head of the B Cell HIV Unit In the Section of the NIAID Laboratory of Immunoregulation
View this article at: http://www.jci.org/articles/view/74351?key=97bbd7f61e344de76f06
Susan Moir and colleagues, at the National Institutes of Health, Bethesda, have now found that downregulating the expression of any one of 9 known and putative B cell inhibitory cell-surface proteins on exhausted B cells from individuals infected with HIV enhanced their in vitro proliferation and function. Moir and colleagues therefore suggest that strategies aimed at reversing the effects of inhibitory cell-surface proteins may enhance immune responses in individuals infected with HIV. As exhausted B cells are also found in individuals infected with other persisting viruses, this approach might also be of benefit for these individuals.TITLE: Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors AUTHOR CONTACT:
NIH Scientists Find More Health Benefits From Starting HIV Treatment - Printer Friendly Page - HIV in the News - HealthHIV
NIH Scientists Find More Health Benefits From Starting HIV Treatment - HIV in the News - News | HealthHIV
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