In the second report, Dr. Stephen Chanock, head of the Genomic Variation Section at the U.S. National Cancer Institute, and his colleagues found genes associated with prostate cancer on chromosomes 7, 10 and 11, as well as nine other gene locations that are suggestive of an association with prostate cancer.
"We are finding the places in the genome that are associated with the risk for prostate cancer," Chanock
said."The reason this is so important is that prostate cancer is a complex disease and is not due to one genetic defect or one environmental exposure," he
Similar findings are being reported with breast cancer, colon cancer and lung cancer, Chanock
said."The same thing is happening in other diseases, such as diabetes, heart disease and stroke," he
said."Most diseases are complex and associated with multiple genes."
Exactly how each of these genes contributes to the risk for prostate cancer isn't clear, Chanock
said."Some of them may be responsive to environmental triggers, such as what you eat or what you inhale," he
...SOURCES: Stephen Chanock, M.D., head, Genomic Variation Section, U.S. National Cancer Institute, Bethesda, Md.; Rosalind Eeles, M.D., Ph.D., Reader, Clinical Cancer Genetics, The Institute of Cancer Research, Sutton, U.K.; Durado Brooks, M.D., director, prostate and colorectal cancers, American Cancer Society, Atlanta; Feb. 10, 2008, Nature Genetics, online