Dr. Stanley Jacob of the Oregon Health Sciences University observed this and later identified this substance as DMSO, a healing penetrant that instantly soaks in through the skin and reduces pain.Eventually, Dr. Jacob discovered that the active healing agent in DMSO is MSM.
Dr. Stanley W. Jacob, a Director and Senior Consultant to Pharma 21, and his research team at Oregon Health Sciences University have been actively investigating DMSO as a therapeutic agent since 1963.Dr. Jacob and an associate, jointly hold United States Patent No. 3,549,770, issued in December 1970, covering the medical uses of DMSO.Dr. Jacob received his early medical training at Ohio State University where he obtained his MD, and completed his Surgery Residency at Harvard Medical School.Dr. Jacob currently holds the Gerlinger Chair in Surgery and Surgical Research at Oregon Health Sciences University in Portland, Oregon.Dr. Jacob is the recipient of many distinguished honors including the Kemper Foundation Research Scholar, Governor's Award for Outstanding Northwest Scientist, German Science Award (for the most significant medical contribution in the world for 1964) and the Humanitarian of the Year Award, given by the National Health Federation.Dr Jacob has published over 150 peer-reviewed papers and is the author of 8 medical textbooks.
Dr. Stanley Jacob, the father of DMSO offers information on DMSO & MSM
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According to Stanley Jacob, MD, a former head of the organ transplant program at Oregon Health Sciences University in Portland, more than 40,000 articles on its chemistry have appeared in scientific journals, which, in conjunction with thousands of laboratory studies, provide strong evidence of a wide variety of properties. (See Major Properties Attributed to DMSO) Worldwide, some 11,000 articles have been written on its medical and clinical implications, and in 125 countries throughout the world, including Canada, Great Britain, Germany, and Japan, doctors prescribe it for a variety of ailments, including pain, inflammation, scleroderma, interstitial cystitis, and arthritis elevated intercranial pressure.
The history of DMSO as a pharmaceutical began in 1961, when Dr. Jacob was head of the organ transplant program at Oregon Health Sciences University.
This early public interest interfered with the ability of Dr. Jacob--or, later, the FDA--to see that experimentation and use were safe and controlled and may have contributed to the souring of the mainstream medical community on it.
Why, if DMSO possesses half the capabilities claimed by Dr. Jacob and others, is it still on the sidelines of medicine in the United States today?
"It's a square peg being pushed into a round hole," says Dr. Jacob.
Others, such as Terry Bristol, a Ph.D. candidate from the University of London and president of the Institute for Science, Engineering and Public Policy in Portland, Oregon, who assisted Dr. Jacob with his research in the 1960s and 1970s, believe that the smell of DMSO may also have put off the drug companies, that feared it would be hard to market.
Dr. Jacob believes the FDA "blackballed" DMSO, actively trying to kill interest in a drug that could end much suffering.
The first quality that struck Dr. Jacob about the drug was its ability to pass through membranes, an ability that has been verified by numerous subsequent researchers.1 DMSO's ability to do this varies proportionally with its strength--up to a 90 percent solution.
Dr. Jacob said at a hearing of the U.S. Senate Subcommittee on Health in 1980, "DMSO is one of the few agents in which effectiveness can be demonstrated before the eyes of the observers....If we have patients appear before the Committee with edematous sprained ankles, the application of DMSO would be followed by objective diminution of swelling within an hour.
Dr. Jacob remains convinced that it can play a significant role in the treatment of arthritis.
Others, however, such as Dr. Jacob and Dr. de la Torre, see the FDA approval of DMSO for interstitial cystitis and the more recent FDA go-ahead for DMSO trials with closed head injury as new indications of hope.
Dr. Jacob continues to believe that DMSO should not even be called a drug but is more correctly a new therapeutic principle, with an effect on medicine that will be profound in many areas.
Herschler, R., Jacob, S.W.
The case of dimethyl sulfoxide.
About forty years ago, Dr. Stanley Jacob and Dr. Robert Herschler, chemists with the pulp and paper plant Crown Zellerbach Corporation, were asked to find a use for lignin, one of the primary waste products of the plant.
The authors are: Stanley W. Jacob, M.D., Head of the DMSO Pain Clinic in Portland, OR, and Professor at the Oregon Health Sciences University; and Ronald M. Lawrence, M.D., Ph.D., Founder of the International Association for the Study of Pain, and the American Association for the Study of Headaches.
Jacob, S.W: The Current Status of MSM in Medicine.
Med. Prev., 1983.
Jacob, S.W. and Herschler, R.J.: Introductory Remarks: Dimethylsulfoxide after Twenty Years.
Stanley W. Jacob
The MSM Advisory Authority is headed by the world's leading expert on MSM.
The MSM Guide wishes to thank our MSM expert for their invaluable help in creating this resource for the entire MSM medical community.
Stanley W. Jacob, M.D., F.A.C.SStanley Jacob has held the Gerlinger Chair in Surgery at the Oregon Health & Sciences University Medical School since 1981.
He was chief resident in surgery for Harvard Medical Service at Boston City Hospital, and also served as an instructor of surgery at Harvard Medical School.Dr. Jacob is considered the leading medical authority on MSM having pioneered its clinical use in patients and documenting case studies of its efficacy for over 20 years.
Dr. Jacob has received numerous honors and awards for his work including the German Science Award for the world's most significant medical contribution and Humanitarian of the Year Award from the National Health Federation.
He is author of 150 scientific articles and seven medical textbooks.
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