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This profile was last updated on 2/10/15  and contains information from public web pages and contributions from the ZoomInfo community.

Scott E. Simonet

Wrong Scott E. Simonet?

Vice President

Phone: (805) ***-****  
Amgen Inc.
One Amgen Center Drive
Thousand Oaks , California 91320
United States

Company Description: Amgen Inc. (Amgen) is an independent biotechnology medicines company. The Company discovers, develops, manufactures and markets medicines for grievous illnesses. It...   more

Employment History


  • Ph.D.
  • Ph.D
26 Total References
Web References
Osteoporosis: People, 30 July 2005 [cached]
Scott Simonet, Ph.D., Director, Research Department of Metabolic Disorders
Scott Simonet, Ph.D.
Scott Simonet, Ph.D.Director, Research Department of Metabolic Disorders Bone and Mineral MetabolismAmgen
Scott received his Ph.D. in Molecular Biology and Biochemistry from the University of South Florida, College of Medicine in 1988.He subsequently received an Individual National Research Service Award from the NIH to perform postdoctoral training at the Gladstone Foundation Laboratories for Cardiovascular Disease at the University of California, San Francisco, where he studied regulation of apolipoprotein gene expression with John Taylor and Bob Mahley.
Scott came to Amgen as a Research Scientist in February of 1992 and began to search for secreted proteins, which might have therapeutic utility.In 1994 he was part of a group contributing to Amgen's Genomics program that identified and determined the function of a secreted protein in the TNFR Superfamily called osteoprotegerin (OPG).This group showed that OPG was a critical regulator of bone mineral density and acts by inhibiting the actions of RANKL on osteoclastogenesis.In 1998, this work received an award from the American Society of Bone and Mineral Research for Outstanding Research on the Pathophysiology of Osteoporosis.
Scott is currently Director of the Bone and Mineral Metabolism Research group in the Department of Metabolic Disorders at Amgen.He heads a group of 33 scientists working on developing novel therapies for osteoporosis and other bone related diseases.
W. Scott Simonet, ..., 23 Dec 2013 [cached]
W. Scott Simonet, Ph.D.
Vice President, Research Department of Metabolic Disorders Amgen
BIT's 10th Annual Congress of International Drug Discovery Science and Technology, 2 Feb 2013 [cached]
Dr. Scott Simonet, Vice President, Metabolic Disorders Therapeutic Area, Amgen, USA
Amgen - Media - Feature - Amgen Scientists Recognized for “Most-Cited” Paper on Osteoclast Differentiation, 9 April 2009 [cached]
The authors, William J. Boyle, Scott Simonet and David Lacey, worked together at Amgen in the 1990s.
Lacey is now senior vice president of Research at Amgen and Simonet is executive director of Research in the area of Metabolic Disorders at Amgen.
Amgen's Scott Simonet.
Last to present was Scott ..., 1 May 2011 [cached]
Last to present was Scott Simonet, Ph.D, vice president of research for Amgen. Simonet described the 15-year process to discover and develop Amgen's denosumab, a drug that regulates bone density and helps the human body limit bone reabsorbtion. With precursor science first discovered in 1995, the product received FDA and European regulatory approval to treat osteoporosis in 2010, as well as FDA approval for cancer-related indications in the same year. While Simonet was sparing in his willingness to express complaints associated with denosumab's approval process, he did make a point to show the length and complexity of the product's discovery and development chain.
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