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Wrong Sanjeev Gupta?

Sanjeev Gupta

The Eleazar and Feige Reicher Chair In Translational Medicine

Albert Einstein College of Medicine

HQ Phone:  (718) 430-2000

Direct Phone: (718) ***-****direct phone

Email: s***@***.edu

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I agree to the Terms of Service and Privacy Policy. I understand that I will receive a subscription to ZoomInfo Community Edition at no charge in exchange for downloading and installing the ZoomInfo Contact Contributor utility which, among other features, involves sharing my business contacts as well as headers and signature blocks from emails that I receive.

Albert Einstein College of Medicine

1300 Morris Park Avenue Belfer Building, Room 1008

The Bronx, New York,10461

United States

Company Description

About Albert Einstein College of Medicine ?Albert Einstein College of Medicine is one of the nation's premier centers for research, medical education and clinical investigation. During the 2015-2016 academic year, Einstein is home to 731 M.D. students, 193 Ph....more

Web References(21 Total References)


Gene Expression - The Journal of Basic Liver Research

www.cognizantcommunication.com [cached]

Sanjeev Gupta, Albert Einstein College of Medicine, USA


Rajasthan University for Health Sciences

ruhsraj.org [cached]

Dr. Sanjeev Gupta
Professor, Department of Medicine Albert Einstein College of Medicine, NY, USA


09/08 - Snow White... - MSMR: What A Year!

whatayear.org [cached]

This is where Dr. Sanjeev Gupta of the Albert Einstein College of Medicine in New York comes in. "These cases and evidence from previous studies suggested that something important was happening with Factor VIII and liver cells," said Dr. Gupta, a Professor of Medicine and Pathology, and an expert in Hepatology: The study of the liver, gallbladder, and pancreas.
Dr. Gupta initially hypothesized that hepatocytes were making Factor VIII because of their wide variety of roles in the liver. To test this hypothesis, Dr. Gupta used a mouse model of Hemophilia A where the Factor VIII gene had been disrupted by DNA recombination methods or " Knocked out: A model organism where a gene has been removed from the genome. Dr. Gupta's team then injected these hemophilia mice with normal hepatocytes to see if they would begin to produce Factor VIII. They did not. So That Didn't Work. What Do We Do Now? So, contrary to what Dr. Gupta had initially expected, transplantation of healthy hepatocytes did not have an effect on Factor VIII levels in hemophilia mice. "I was surprised," said Dr. Gupta. "But I knew that hepatocytes were not the only option. It was possible that endothelial cells were making Factor VIII, or that Factor VIII was being produced by something different. Dr. Gupta and his team then examined the capacity of cells other than hepatocytes (specifically, liver sinusoidal endothelial cells) and found that Factor VIII appeared in the blood of mice after transplantation of these cells. This was the first clue that transplantation of liver sinusoidal endothelial cells might be capable of correcting Hemophilia A. In the next step, Dr. Gupta and his team determined whether liver endothelial cells could be replaced by transplanted cells. "This time," said Dr. Gupta, "large amounts of Factor VIII appeared in the blood stream and were maintained at high levels indefinitely. Moreover, hemophiliac mice acquired the capability to stop bleeding. In other words, transplanted liver endothelial cells were producing Factor VIII and mice treated with healthy cells had been cured of hemophilia. "This is a huge finding," remarked Dr. Gupta. Dr. Gupta is Professor of Medicine and Pathology: The study of disease. Dr. Sanjeev Gupta


CMH :: Clinical and Molecular Hepatology

www.e-cmh.org [cached]

Sanjeev Gupta
Albert Einstein College of Medicin, USA


www.ruhsraj.org

Dr. Sanjeev Gupta, M.D., Professor, Department of Medicine Gastroenterology & Liver Diseases) Albert Einstein College of Medicine, NY, USA


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