"Indians have the so-called 'thrifty genotype'-our genes are tuned so as to take care of metabolic requirements in periods of limited food intake," says Dr S.K. Wangnoo, senior consultant at Apollo Centre for Obesity, Diabetes and Endocrinology in Delhi.
"An injectable molecule of the GLP-1 class, bydureon, is approved in Europe and awaiting approval in India," says Wangnoo
"Three gliptins," says Wangnoo
, "are approved for usage in India: sitagliptin, saxagliptin and vildagliptin.
The newest gliptin, linagliptin, is awaiting approval in India.
Saxaglyptin has proved effective in the treatment of type 2 diabetics with kidney problems (not end-stage renal disease).
This molecule is marketed by Bristol-Myers Squibb
Studies presented at the EASD
indicate that long-term treatment of type 2 diabetes with gliptins for two years appeared to maintain improvement in HbA1C levels, adds Wangnoo
"These are relatively safe, with low potential for hypoglycaemia," he
"The EndoBarrier is a liner that fits inside a section of the intestine," says Wangnoo