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Wrong Richard McCallum?

Richard W. McCallum

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Background Information

Employment History

Professor and Founding Chair

Gi STIMULATION INC


Consultant

Tranzyme Pharma Inc


Affiliations

Prostrakan Pharm

Advisory Board


Smart Pill Corporation

Advisory Board


Australian Medical Association Limited

Member


New York Academy of Sciences

Member


International Electrogastrophy Society

Member


American Federation for Clinical Research

Member


SmartPill Corporation

Scientific Advisory Board Member


American Neurogastroenterology and Motility Society

Member


Tranzyme Pharma Inc

Clinical Advisor


Gastroparesis & Dysmotilities Association

Medical and Allied Health Advisor


Education

M.D.

The University of Kansas Medical Center


M.D.

Univ. of Kansas Medical Center , Kansas City


M.D.

University of Kansas School of Medicine


MD

The National Institute of Diabetes and Digestive and Kidney Diseases


MD

Xavier University School of Medicine


bachelor's degree

University of Queensland


medical degree

Queensland Medical School


medical degree

University of Queensland


Web References(58 Total References)


www.practicalgastro.com

by Ihsan Al-Bayati, Richard W. McCallum
Ihsan Al-Bayati, MD, First Year Resident, Department of Internal Medicine, Texas Tech University, Paul L. Foster School of Medicine Richard W. McCallum, MD, Professor and Founding Chair of Medicine, Department of Internal Medicine Director, Center of Neurogastroenterology and GI Motility, El Paso, TX


www.tranzyme.com [cached]

Richard McCallum, M.D.
Professor, Founding Chairman, Department of Internal Medicine, Texas Tech University Health Sciences Center at El Paso Dr. McCallum has been appointed Professor and Founding Chairman of the Department of Internal Medicine, Texas Tech University Health Sciences Center at El Paso. Prior to coming to TTUHSC, Dr McCallum was Professor of Medicine and Director of the Center for Gastrointestinal Nerve and Muscle Function and Chief of Division of Gastrointestinal Motility, University of Kansas School of Medicine since 2004. From 1996 to 2004, Dr. McCallum was Professor of Medicine Chief, and Program Director, Division of Gastroenterology and Hepatology, University of Kansas Medical Center, Kansas City, Kansas. He also served as attending physician at the Kansas City Veteran's Administration Medical Center, Missouri. Before his appointments in Kansas City and Missouri, Dr. McCallum was Professor of Medicine and Program Director, Division of Gastroenterology, Hepatology and Nutrition at the University of Virginia School of Medicine, Charlottesville, Virginia where he was Chief of the Division of Gastroenterology for almost ten years. He was awarded the Paul Janssen Endowed Chair as Professor of Medicine in 1987. After completing his undergraduate studies at the University of Queensland, he earned his medical degree at the Queensland Medical School in Brisbane, Australia. From there Dr. McCallum began his post graduate studies as a Rotating Intern on the LSU Service at Charity Hospital New Orleans and then a 2 year residency in Internal Medicine at Barnes Hospital in St. Louis. Dr. McCallum began his gastroenterology career at the University of California (UCLA) where he did his GI Fellowship and then was an attending physician and Assistant Professor of Medicine at the UCLA Hospital for the Health Sciences until 1976. From there, he joined the faculty of Yale University School of Medicine as an Assistant Professor of Medicine and later, as Associate Professor of Medicine. He was attending physician, Yale-New Haven Hospital and Director of Gastroenterology Diagnostic Laboratories, also at Yale-New Haven Hospital from 1976 to 1985. Dr. McCallum is board certified by the American Board of Internal Medicine with a subspecialty in gastroenterology. Among his extensive list of professional honors and memberships are Fellow of the American College of Physicians, Fellow of the Royal Australian College of Physicians, Fellow of the American College of Gastroenterology, member of the American Society for Clinical Investigation, President of the Southern Society for Clinical Investigation, & President of the International Electrogastroglam Society. He has also served on several editorial boards and national committees. Dr. McCallum is the author or co-author of over 450 publications and edited 12 text books. Dr. McCallum's area of clinical interest and research is the field of gastrointestinal motility, neurogastroenterology and functional bowel disorders. He has been focused on advancing knowledge related to diagnostic approaches, pharmacology and device technology. He is a pioneer in the area of gut electro-physiology and developed the concept of electrical "pacing" of the stomach to treat gastroparesis, particularly related to diabetes mellitus, as well as nausea and vomiting and obesity. He has an NIH grant in this field of gastroparesis which he will be bringing with him to TTUHSC as well as funding from the American Diabetes Association and Pharmaceutical and device companies. Dr. McCallum will bring his research team with him specifically Dr. Irene Sarosiek, will be the Director of Research in GI Neurogastroenterology and Electrical Stimulation and her husband, Jerzy Sarosiek, MD, PhD will continue his laboratory research in addition to being Vice Chair for Research in the department of medicine, providing core lab opportunities for faculty and be a facilitator and catalyst for Research in the Department and collaborative research throughout the school. Dr. McCallum will be the Medical Director of the new diagnostic center for GI Motility and functional bowel disorders being established at Thomason Hospital as a referral center for patients locally, regionally, and nationally and he will continue to see patients referred for these particular medical problems.


www.goldwaterinstitute.org

Richard McCallum and Irene Sarosiek have worked together to treat patients with severe gastrointestinal disorders with domperidone.
McCallum is a professor and founding chairman of the department of internal medicine at the Paul L. Foster School of Medicine at the Texas Tech University Health Sciences Center in El Paso, and director of its Center for Neurogastroenterology and GI Motility. Since 2009, McCallum and Sarosiek have run the FDA-approved expanded access program at the health center to treat patients with domperidone. Fears about heart risks are overblown and based on academic research outside the real-world clinical setting where patients are treated on a daily basis, McCallum said. The academic studies cited by the FDA and other critics of domperidone tend to be “very, very, very poor quality studies,†he said. Many studies were done in countries where domperidone was sold over the counter and failed to account for other factors such as complicating medical conditions and other drugs the patients were taking that also have been linked to QT prolongation and other heart problems. More controlled studies in Canada and other places showed little or no risks in properly screened and monitored patients. Patients in the Texas Tech expanded access program are treated with much higher doses of domperidone than what are typically recommended for patients in Europe, McCallum said. Even at that, he said he has not seen evidence of any significant increase in risk, certainly not enough to outweigh the benefits to patients. “This is a risk-benefit ratio on a population with no options,†McCallum said. “After Reglan, there is no option. So when you boil it down to that, the benefit is great and the risk is miniscule.†At Texas Tech, patients treated with domperidone are carefully monitored with regular electrocardiograms and other tests to ensure they are not experiencing QT prolongation or other serious complications, McCallum said. No deaths of any of his patients have been linked to domperidone use, he said. McCallum does not fault the FDA for restricting availability of domperidone or requiring it to be obtained only through the expanded access program. The agency is in an unusual position. Since Janssen did not complete its new drug application, domperidone was never approved by the FDA to treat gastric disorders or any other condition in the United States. The expanded access program is a means to allow patients to be treated despite that, he said. However, McCallum said risk aversion at the FDA does seem to be a factor in the way domperidone is treated. McCallum of Texas Tech co-authored a study published in 2015 that noted only 10 of 1,304 patients in the van Noord study were using domperidone at the time they experienced sudden cardiac death, “which translates to a statistically non-significant increased risk.’’ McCallum, the Texas Tech doctor, said about 100 to 120 patients are getting domperidone treatment through the expanded access program in El Paso.


www.motustx.com

Relamorelin may offer a much-needed opportunity for patients with diabetic gastroparesis to have symptom relief and improved quality of life," said Richard McCallum, MD, of Texas Tech University.


www.practicalgastro.com [cached]

Richard W. McCallum, M.D.
Richard W. McCallum, M.D.


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