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2015-06-17T00:00:00.000Z

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Wrong Pierre-Yves Desprez?

Dr. Pierre-Yves Desprez

Cancer Research

CPMCRI Currents

HQ Phone: (415) 600-3688

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CPMCRI Currents

2200 Webster Street 5Th Floor

San Francisco, California 94115

United States

Find other employees at this company (17)

Background Information

Employment History

Cancer Researcher

California Pacific Medical Center

Principal Investigator

Cancer Research Institute

Affiliations

Board Member
Sutter Health

Education

Ph.D

California Pacific Medical Center Research Institute

Ph.D.

University of Lyon

Web References (120 Total References)


Our People: California Pacific Medical Research Institute

www.cpmcri-currents.org [cached]

Pierre-Yves Desprez, Ph.D.


Cancer Research | Dr. Pierre-Yves Desprez | CPMCRI-currents

www.cpmcri-currents.org [cached]

Pierre-Yves Desprez, Ph.D. Cancer Research | Dr. Pierre-Yves Desprez | CPMCRI-currents

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Home>Our People>Discovery Investigators>Desprez Lab> Pierre-Yves Desprez, Ph.D.
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Pierre-Yves Desprez, Ph.D., Senior Scientist
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Liliana Soroceanu, Sean McAllister and Pierre-Yves Desprez, in Cancer Research 2013 and showing the effects of targeting Id-1 (either by genetic knockdown or by using a cannabinoid compound) on the behavior of aggressive cancer cells.
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Dr. Desprez and his colleagues found that Id genes and proteins not only correlate with but also determine the level of aggressiveness of human breast and prostate cancer cells, and that Id-1 regulates multiple tumor-promoting pathways in brain cancer (glioblastoma). In collaboration with CPMCRI scientist Dr. Sean McAllister, recent investigations by Dr. Desprez have determined that cannabidiol (CBD), a cannabinoid with a low toxicity profile, inhibits human cancer cell proliferation and invasion through differential modulation of specific pathways, and down-regulates Id-1 gene expression.
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Dr. Desprez is among a group of investigators leading cancer research at CPMCRI.
Training
Before joining CPMCRI, Dr. Desprez completed his Ph.D. at the University of Lyon in France, and worked as a postdoctoral fellow in the laboratories of Drs.
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Pierre-Yves Desprez, Ph.D., Senior Scientist Primary Research Interests
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Pierre-Yves Desprez, Ph.D.


News Box

www.cpmc.org [cached]

"We found high levels of expression of the Id-1 gene in breast tumor biopsies from patients with aggressive cancer," says Dr. Pierre-Yves Desprez of CPMCRI, the leading author of this study."But up until now, we didn't know if it could also function as a potential gene therapy target for suppressing metastasis in humans.Our pre-clinical study with mice confirms that Id-1 gene therapy suppresses the spread of cancer and blocks metastasis," Dr. Desprez says.

What does this mean for human cancer patients?According to Dr. Desprez, "as soon as the same methodology is applicable to humans, Id-1 gene could represent a highly promising target for breast cancer patients with invasive and metastatic cancer.Metastasis is what kills patients, not the primary tumor."
The study published in PNAS was a "bench to bedside" project done entirely at California Pacific Medical Center and primarily funded by the National Cancer Institute and the California Breast Cancer Research Program.It represents the endpoint of several years of collaboration among basic scientists (Drs. Nancy M. Lee, Robert J. Debs, and Pierre-Yves Desprez) and clinicians/pathologists (Drs. Peter C. Richards and James L. Bennington).
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More Id-1 would mean a bad prognosis for breast cancer patients and therefore more aggressive treatment to prevent the spread of the disease," said Dr. Desprez.


California Pacific Medical Center - Research

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Pierre Desprez, PhD Research Seminars415-600-1760 Email: DesprePY@cpmcri.org


IRBNet | CPMCRI Currents

www.cpmcri-currents.org [cached]

Pierre-Yves Desprez, Ph.D.

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