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This profile was last updated on 2/28/14  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Pamela A. Maher

Wrong Dr. Pamela A. Maher?

Senior Scientist At the Cellular ...

Salk Institute
10010 N Torrey Pines Road
La Jolla, California 92037
United States

Company Description: The Salk Institute for Biological Studies in La Jolla, California, is an independent nonprofit organization dedicated to fundamental discoveries in the life...   more

Employment History


  • Ph.D.
43 Total References
Web References
Able Me & Associates! - What's New!, 30 Aug 2011 [cached]
Pam Maher, Ph.D., senior scientist at the Salk Institute's Cellular Neurobiology Lab, initially ID'd fisetin as a neuro-protective flavonoid. She said, "In plants, flavonoids act as sunscreens and protective leaves and fruits from insects.
"Since the development of a basic ..., 17 Oct 2006 [cached]
"Since the development of a basic understanding of the biochemical pathways involved in memory formation, the holy grail of CNS research in the pharmaceutical industry is the identification of a safe, orally active drug that activates memory-associated pathways and enhances memory," says lead author Pamela Maher, Ph.D., a researcher in the Cellular Neurobiology Laboratory at the Salk Institute.
Maher hit upon the beneficial effects of fisetin when she screened a collection of flavonoids, substances with anti-oxidant activities found in many plants, for their neuroprotective abilities in tissue culture models of neurodegenerative disease.
Maher found that some of those compounds, including fisetin, induced differentiation or maturation of neural cells.Maher explains, "That suggested to us that these compounds might be particularly beneficial, since they might not only protect neural cells from dying but might be able to promote new connections between nerve cells."
Interestingly the signaling pathway activated by fisetin in neural differentiation also played a role in memory formation, a process neuroscientists call "long-term potentiation" or LTP.LTP allows memories to be stored in the brain by strengthening connections between neurons."We wanted to find out whether we could detect any effects of fisetin on long-term potentiation and the formation of memories in animals," Maher recalls.
Since the hippocampus plays an important role in establishing new memories, Maher, and co-authors Tatsuhiro Akaishi and Kazuho Abe, both at Musashino University in Tokyo, Japan, extended the study and found that fisetin activates the same signaling pathway in rat hippocampal tissues and also induces LTP.
"The good news is that fisetin is readily available in strawberries but the bad news is that because of its natural product status there may be little financial interest in getting it into human clinical trials for diseases associated with memory loss such as Alzheimer's, where the treatment options are currently very limited," says Maher.
Besides strawberries, fisetin is found in tomatoes, onions, oranges, apples, peaches, grapes, kiwifruit and persimmons.
Pamela Maher | Nov. 25 People ..., 12 Dec 2010 [cached]
Pamela Maher | Nov. 25 People in the News | full story San Diego Community News Group - Nov 25 People in the News
Pamela Maher
Pamela Maher
Pamela Maher, Ph.D, a senior staff scientist in the Salk Cellular Neurobiology Laboratory, led a team of researchers in the discovery that fisetin, a natural compound found in some fruits and vegetables, slows the onset of symptoms associated with Huntington's disease, an inherited disorder caused by a genetic repetition that destroys neurons in parts of the brain. The team's findings showed that when fisetin was fed to fruit flies with mutant Huntingtin genes in the brain, they had fewer motor defects, such as impaired eye development, and extended their life spans by 30 percent.
Although fisetin does not reverse or stop progress of the disease, especially in its advanced stages, Maher's team found that the compound may slow the progression of motor problems such as the inability to walk, talk and reason in the early stages of the disease.
Maher and her team's findings were published in the online edition of Human Molecular Genetics. The effects of fisetin in humans with Huntington's disease has not yet been tested; however, Maher and her team's findings lay the groundwork for future research on fisetin's benefits for patients with early signs of the disease.
Pamela Maher, Salk ..., 15 Nov 2012 [cached]
Pamela Maher, Salk Institute
Highlights include the perspective by ..., 1 June 2012 [cached]
Highlights include the perspective by David Schubert and Pamela Maher of the Salk Institute for Biological Studies (CA, USA) that considers a different approach to drug discovery in this disease area, highlighting the fact that there are currently "no drugs that halt the progression of any age-associated neurodegenerative disease.
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