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Wrong Orson Moe?

Orson W. Moe

Director of the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research

UT Southwestern Medical Center

HQ Phone:  (214) 645-8300

Direct Phone: (214) ***-****direct phone

Email: o***@***.edu

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I agree to the Terms of Service and Privacy Policy. I understand that I will receive a subscription to ZoomInfo Community Edition at no charge in exchange for downloading and installing the ZoomInfo Contact Contributor utility which, among other features, involves sharing my business contacts as well as headers and signature blocks from emails that I receive.

UT Southwestern Medical Center

5323 Harry Hines Blvd.

Dallas, Texas,75390

United States

Company Description

UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution's faculty includes many distinguished members, including six who have been award...more

Background Information

Employment History

Professor

University of Texas Southwestern Medical Center


Associate Professor of Internal Medicine

Texas Southwestern Medical Center


Editorial Board

American Journal of Physiology


Affiliations

American Society of Nephrology

Moderator


American Physiologic Society

Member


American Association of Physicians

Member


ASCR

Member


Education

MD

University of Texas Southwestern Medical Center


medical degree

University of Toronto


Web References(39 Total References)


Medical News

www.biocellultravital.com [cached]

This may explain why supplementing Klotho levels helps counteract a major side-effect associated with the disease, said Dr. Orson Moe, director of the Charles & Jane Pak Center for Mineral Metabolism and Clinical Research at UT Southwestern and the senior author of the study.
Mice with chronic kidney disease exhibit low levels of Klotho in their kidneys, blood and urine, indicating that CKD is a state of systemic Klotho deficiency, Dr. Moe said. In the study, researchers also tested urine from 53 human participants, including 40 CKD patients, and found that they also had low levels of the essential protein. "It can be a vicious cycle, where CKD begets low Klotho and low Klotho accelerates CKD," Dr. Moe said. The beneficial effect of proper Klotho levels on vascular calcification goes beyond the hormone's effect on kidney function, suggesting a direct protective effect of Klotho on the vasculature, Dr. Moe said. According to the research, Klotho lessens vascular calcification by enhancing the urine's phosphate excretions (essential for building and repairing bones and teeth, helping nerve function and making muscles contract, but it can be toxic when levels are high); and preserving kidney fluid filtration. Most importantly, Klotho also appears to inhibit vascular smooth-muscle phosphate uptake and calcification, a complication of CKD that can significantly increase risk of death. "We tested three hypotheses," Dr. Moe said. "The first was that CKD is a state of Klotho deficiency; the second, that Klotho is an early marker of CKD; and the third, that Klotho deficiency contributes to vascular calcification and Klotho replacement ameliorates CKD via multiple mechanisms. The data we collected seem to bear out all three." The study's findings also suggest that Klotho replacement therapy may eventually prove to be effective in battling CKD as well as in preventing and reversing its complications. "It is our hope that this and future research will ultimately lead to better ways to retard the progression of CKD and avoid the dire consequences associated with the disease," Dr. Moe said.


biochemistry.utoronto.ca

Orson Moe (UT Southwestern Medical Center)


Anti-Aging Hormone Klotho May Prevent Complications In Chronic Kidney Disease

www.biocellultravital.com [cached]

This may explain why supplementing Klotho levels helps counteract a major side-effect associated with the disease, said Dr. Orson Moe, director of the Charles & Jane Pak Center for Mineral Metabolism and Clinical Research at UT Southwestern and the senior author of the study.
Mice with chronic kidney disease exhibit low levels of Klotho in their kidneys, blood and urine, indicating that CKD is a state of systemic Klotho deficiency, Dr. Moe said. In the study, researchers also tested urine from 53 human participants, including 40 CKD patients, and found that they also had low levels of the essential protein. "It can be a vicious cycle, where CKD begets low Klotho and low Klotho accelerates CKD," Dr. Moe said. The beneficial effect of proper Klotho levels on vascular calcification goes beyond the hormone's effect on kidney function, suggesting a direct protective effect of Klotho on the vasculature, Dr. Moe said. According to the research, Klotho lessens vascular calcification by enhancing the urine's phosphate excretions (essential for building and repairing bones and teeth, helping nerve function and making muscles contract, but it can be toxic when levels are high); and preserving kidney fluid filtration. Most importantly, Klotho also appears to inhibit vascular smooth-muscle phosphate uptake and calcification, a complication of CKD that can significantly increase risk of death. "We tested three hypotheses," Dr. Moe said. "The first was that CKD is a state of Klotho deficiency; the second, that Klotho is an early marker of CKD; and the third, that Klotho deficiency contributes to vascular calcification and Klotho replacement ameliorates CKD via multiple mechanisms. The data we collected seem to bear out all three." The study's findings also suggest that Klotho replacement therapy may eventually prove to be effective in battling CKD as well as in preventing and reversing its complications. "It is our hope that this and future research will ultimately lead to better ways to retard the progression of CKD and avoid the dire consequences associated with the disease," Dr. Moe said.


www.dailyindia.com

The beneficial effect of proper Klotho levels on vascular calcification goes beyond the hormone's effect on kidney function, suggesting a direct protective effect of Klotho on the vasculature, said Dr. Orson Moe, director of the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research at UT Southwestern and the senior author of the study.


gbcourses.com

This may explain why supplementing Klotho levels helps counteract a major side-effect associated with the disease, said Dr. Orson Moe, director of the Charles Jane Pak Center for Mineral Metabolism and Clinical Research at UT Southwestern and the senior author of the study.
Mice with chronic kidney disease exhibit low levels of Klotho in their kidneys, blood and urine, indicating that CKD is a state of systemic Klotho deficiency, Dr. Moe said. In the study, researchers also tested urine from 53 human participants, including 40 CKD patients, and found that they also had low levels of the essential protein. It can be a vicious cycle, where CKD begets low Klotho and low Klotho accelerates CKD, Dr. Moe said. The beneficial effect of proper Klotho levels on vascular calcification goes beyond the hormones effect on kidney function, suggesting a direct protective effect of Klotho on the vasculature, Dr. Moe said. According to the research, Klotho lessens vascular calcification by enhancing the urines phosphate excretions (essential for building and repairing bones and teeth, helping nerve function and making muscles contract, but it can be toxic when levels are high); and preserving kidney fluid filtration. Most importantly, Klotho also appears to inhibit vascular smooth-muscle phosphate uptake and calcification, a complication of CKD that can significantly increase risk of death. We tested three hypotheses, Dr. Moe said. The first was that CKD is a state of Klotho deficiency; the second, that Klotho is an early marker of CKD; and the third, that Klotho deficiency contributes to vascular calcification and Klotho replacement ameliorates CKD via multiple mechanisms. The data we collected seem to bear out all three. The studys findings also suggest that Klotho replacement therapy may eventually prove to be effective in battling CKD as well as in preventing and reversing its complications. It is our hope that this and future research will ultimately lead to better ways to retard the progression of CKD and avoid the dire consequences associated with the disease, Dr. Moe said.


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