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This profile was last updated on 6/17/15  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Orson W. Moe

Wrong Dr. Orson W. Moe?

Professor

Phone: (214) ***-****  
Email: o***@***.edu
Local Address:  Texas , United States
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas , Texas 75390
United States

Company Description: UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education....   more
Background

Employment History

  • Director of the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research
    UT Southwestern Medical Center
  • Director
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research
  • Professor
    University of Texas Southwestern Medical Center
  • Professor of Internal Medicine and Physiology
    University of Texas Southwestern Medical Center

Board Memberships and Affiliations

Education

  • medical degree
    University of Toronto
  • MD
    University of Texas Southwestern Medical Center
35 Total References
Web References
The beneficial effect of proper Klotho ...
www.dailyindia.com, 20 May 2011 [cached]
The beneficial effect of proper Klotho levels on vascular calcification goes beyond the hormone's effect on kidney function, suggesting a direct protective effect of Klotho on the vasculature, said Dr. Orson Moe, director of the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research at UT Southwestern and the senior author of the study.
Orson W. Moe, ...
www.asn-online.org, 28 Feb 2016 [cached]
Orson W. Moe, MD University of Texas Southwestern Medical Center
Orson W. Moe, MD - ...
www.asn-online.org, 28 Feb 2016 [cached]
Orson W. Moe, MD - [disclosures]
American Society of Nephrology | About ASN - Orson W. Moe, MD
www.asn-online.org, 8 Dec 2007 [cached]
Orson W. Moe, MD American Society of Nephrology | About ASN - Orson W. Moe, MD
...
Orson W. Moe, MD, BRCU Faculty
...
Orson W. Moe, MD, received his medical degree from the University of Toronto and is currently Professor of Internal Medicine and Physiology at the University of Texas Southwestern Medical Center. He is the Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research. He is also Chief of the Nephrology Division at Southwestern. Dr. Moe is the holder of the Charles and Jane Pak Distinguished Chair in Mineral Metabolism Research and the Donald Seldin Professorship in Clinical Investigation.
Dr. Moe conducts both basic science and patient-oriented research on renal physiology and metabolism as well as epithelial biology, striving to cross from the level of the whole patient to animal and cell culture models, and down to single molecules. He has edited Current Opinion in Nephrology and Hypertension, and the textbook, Seldin and Giebiesch's The Kidney: Physiology and Pathophysiology. He also serves on the editorial board of the American Journal of Physiology, Journal of American Society of Nephrology, Clinical and Experimental Nephrology, and Journal of Nephrology. He is currently a member of the American Society of Clinical Research, American Association of Physicians, American Society of Nephrology, and American Physiologic Society.
This may explain why supplementing Klotho ...
www.eurekalert.org, 17 Feb 2011 [cached]
This may explain why supplementing Klotho levels helps counteract a major side-effect associated with the disease, said Dr. Orson Moe, director of the Charles & Jane Pak Center for Mineral Metabolism and Clinical Research at UT Southwestern and the senior author of the study.
Mice with chronic kidney disease exhibit low levels of Klotho in their kidneys, blood and urine, indicating that CKD is a state of systemic Klotho deficiency, Dr. Moe said. In the study, researchers also tested urine from 53 human participants, including 40 CKD patients, and found that they also had low levels of the essential protein.
"It can be a vicious cycle, where CKD begets low Klotho and low Klotho accelerates CKD," Dr. Moe said.
...
The beneficial effect of proper Klotho levels on vascular calcification goes beyond the hormone's effect on kidney function, suggesting a direct protective effect of Klotho on the vasculature, Dr. Moe said.
According to the research, Klotho lessens vascular calcification by enhancing the urine's phosphate excretions (essential for building and repairing bones and teeth, helping nerve function and making muscles contract, but it can be toxic when levels are high); and preserving kidney fluid filtration. Most importantly, Klotho also appears to inhibit vascular smooth-muscle phosphate uptake and calcification, a complication of CKD that can significantly increase risk of death.
"We tested three hypotheses," Dr. Moe said. "The first was that CKD is a state of Klotho deficiency; the second, that Klotho is an early marker of CKD; and the third, that Klotho deficiency contributes to vascular calcification and Klotho replacement ameliorates CKD via multiple mechanisms. The data we collected seem to bear out all three."
The study's findings also suggest that Klotho replacement therapy may eventually prove to be effective in battling CKD as well as in preventing and reversing its complications.
"It is our hope that this and future research will ultimately lead to better ways to retard the progression of CKD and avoid the dire consequences associated with the disease," Dr. Moe said.
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