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This profile was last updated on 7/15/14  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Orson W. Moe

Wrong Dr. Orson W. Moe?

Professor of Medicine and Directo...

Local Address: Dallas, Texas, United States
University of Texas Southwestern Medical Center
 
Background

Employment History

  • Professor, Department of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research
    University of Texas Southwestern Medical Center
  • Nephrologist and Professor of Internal Medicine
    University of Texas Southwestern Medical Center
  • Director
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research
  • Director of the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research
    UT Southwestern Medical Center
  • American Society of Nephrology

Education

  • MD
  • University of Toronto
33 Total References
Web References
American Society of Nephrology | About ASN - Orson W. Moe, MD
www.asn-online.org, 15 July 2014 [cached]
Orson W. Moe, MD American Society of Nephrology | About ASN - Orson W. Moe, MD
...
Orson W. Moe, MD, BRCU Faculty
...
Orson W. Moe, MD, is a graduate of University of Toronto,and completed his residency and a nephrology fellowship at St. Michael's Hospital. He is a Professor of Medicine and Director of the Charles and Jane Pak Center of Mineral Metabolism and Clinical Research at the University of Texas Southwestern Medical Center. His research includes solute transport and metabolism, kidney stones, acid-base disturbance, and cardiovascular complications of CKD. Dr. Moe received the Outstanding Freshman Teacher award voted by 1st year medical students in 2010.
ACP Medicine
www.acpmedicine.com, 5 Mar 2006 [cached]
Orson W. Moe, MD Professor, Department of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX
"If there were serious and common ...
blog.targethealth.com [cached]
"If there were serious and common complications, they would have been more obvious by now," said Dr. Orson Moe, a nephrologist and professor of internal medicine at the University of Texas Southwestern Medical Center in Dallas.
Metabolic syndrome and uric-acid kidney stones
www.heart-watch-blog.com, 20 Sept 2007 [cached]
Other UT Southwestern researchers contributing to the study were Dr. Orson Moe, director of the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, and Beverley Adams-Huet, assistant professor of clinical sciences.
This may explain why supplementing Klotho ...
www.eurekalert.org, 17 Feb 2011 [cached]
This may explain why supplementing Klotho levels helps counteract a major side-effect associated with the disease, said Dr. Orson Moe, director of the Charles & Jane Pak Center for Mineral Metabolism and Clinical Research at UT Southwestern and the senior author of the study.
Mice with chronic kidney disease exhibit low levels of Klotho in their kidneys, blood and urine, indicating that CKD is a state of systemic Klotho deficiency, Dr. Moe said. In the study, researchers also tested urine from 53 human participants, including 40 CKD patients, and found that they also had low levels of the essential protein.
"It can be a vicious cycle, where CKD begets low Klotho and low Klotho accelerates CKD," Dr. Moe said.
...
The beneficial effect of proper Klotho levels on vascular calcification goes beyond the hormone's effect on kidney function, suggesting a direct protective effect of Klotho on the vasculature, Dr. Moe said.
According to the research, Klotho lessens vascular calcification by enhancing the urine's phosphate excretions (essential for building and repairing bones and teeth, helping nerve function and making muscles contract, but it can be toxic when levels are high); and preserving kidney fluid filtration. Most importantly, Klotho also appears to inhibit vascular smooth-muscle phosphate uptake and calcification, a complication of CKD that can significantly increase risk of death.
"We tested three hypotheses," Dr. Moe said. "The first was that CKD is a state of Klotho deficiency; the second, that Klotho is an early marker of CKD; and the third, that Klotho deficiency contributes to vascular calcification and Klotho replacement ameliorates CKD via multiple mechanisms. The data we collected seem to bear out all three."
The study's findings also suggest that Klotho replacement therapy may eventually prove to be effective in battling CKD as well as in preventing and reversing its complications.
"It is our hope that this and future research will ultimately lead to better ways to retard the progression of CKD and avoid the dire consequences associated with the disease," Dr. Moe said.
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