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This profile was last updated on 9/30/14  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Nicholas D.P. Cosford

Wrong Dr. Nicholas D.P. Cosford?

Principal Investigator

Burnham Institute
10901 N. Torrey Pines Road
La Jolla, California 92037
United States

Company Description: Burnham Institute for Medical Research, founded in 1976, is an independent not-for-profit biomedical research institution dedicated to advancing the frontiers of...   more
Background

Employment History

Education

  • Ph.D.
27 Total References
Web References
Sanford-Burnham Medical Research Institute - Faculty - Cosford, N., Ph.D.
www.burnham.org, 30 Mar 2010 [cached]
Nicholas Cosford, Ph.D.
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NICHOLAS COSFORD, PH.D. Associate Professor
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Dr. Cosford joined the Sanford-Burnham faculty in January 2008. Prior to that he was Project Manager for the Conrad Prebys Center for Chemical Genomics from 2005 to 2008 and has been Director of Medicinal Chemistry at the Sanford-Burnham La Jolla site since 2006. Dr. Cosford has over 15 years experience leading small-molecule drug discovery projects in the pharmaceutical industry, and more recently at Sanford-Burnham. At Sibia Neurosciences and at Merck Research Laboratories he directed multidisciplinary research teams focused on small molecule hit-to-lead optimization and was responsible for moving several lead compounds through to the clinical phase. Examples include taking a nicotinic receptor agonist (Altinicline, SIB-1508Y) from initiation of research through to Phase II clinical; taking mGluR5 negative allosteric modulators from HTS hits through in vivo proof-of-concept to IND status; and design, synthesis and optimization of an mGluR5 PET tracer clinical candidate. Dr. Cosford's research in the areas of medicinal chemistry and small molecule synthesis has resulted in more than 50 peer reviewed scientific publications, 21 issued patents, and more than 25 additional patent applications pending. In 2006 Dr. Cosford received the FRAXA Research Foundation Award for Outstanding Contributions to Fragile X Research.
Selected Publications Bleicher, Leo; Cosford, Nicholas D. P. Aryl- and heteroaryl-alkyne coupling reactions catalyzed by palladium on carbon and CuI in an aqueous medium.
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Cosford, Nicholas D. P.; Bleicher, Leo; Herbaut, Audrey; McCallum, Stuart; Vernier, Jean-Michel; Dawson, Heather; Whitten, Jeffrey P.; Adams, Pamala; Chavez-Noriega, Laura; et al. (S)-(-)-5-Ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine Maleate (SIB-1508Y): A Novel Anti-Parkinsonian Agent with Selectivity for Neuronal Nicotinic Acetylcholine Receptors.
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Varney, Mark A.; Cosford, Nicholas D. P.; Jachec, Christine.; Rao, Sara P.; Sacaan, Aida; Lin, Fen-Fen; Bleicher, Leo S.; Santori, Emily M.; Flor, Peter J.; Allgeier, Hans; Gasparini, Fabrizio; Kuhn, Rainier; Hess, Stephen D.; Velicelebi, Gonul; Johnson, Edwin C. SIB-1757 and SIB-1893: Selective, Non-competitive Antagonists of Metabotropic Glutamate Receptor Type 5 (mGluR5).
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Smith, Nicholas D.; Huang, Dehua; Cosford, Nicholas D. P. One-Step Synthesis of 3-Aryl- and 3,4-Diaryl-(1H)-Pyrroles Using Tosylmethyl Isocyanide (TOSMIC). Org. Lett. 2002, 4(20), 3537-3539. Cosford, Nicholas D. P.; Tehrani, Lida; Roppe, Jeffrey; Schweiger, Edwin; Smith, Nicholas D.; Anderson, Jeffrey; Bristow, Linda; Brodkin, Jesse; Jiang, Xiaohui; McDonald, Ian; Rao, Sara; Washburn, Mark; Varney, Mark A. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity. Cosford, Nicholas D. P.; Tehrani, Lida; Roppe, Jeffrey; Schweiger, Edwin; Smith, Nicholas D.; Anderson, Jeffrey; Bristow, Linda; Brodkin, Jesse; Jiang, Xiaohui; McDonald, Ian; Rao, Sara; Washburn, Mark; Varney, Mark A. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity.
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Roppe, Jeffrey; Smith, Nicholas D.; Huang, Dehua; Tehrani, Lida; Wang, Bowei; Anderson, Jeffrey; Brodkin, Jesse; Chung, Janice; Jiang, Xiaohui; King, Christopher; Munoz, Benito; Varney, Mark A.; Prasit, Petpiboon; Cosford, Nicholas D. P. Discovery of Novel Heteroarylazoles That Are Metabotropic Glutamate Subtype 5 Receptor Antagonists with Anxiolytic Activity.
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Roppe, Jeffrey; Smith, Nicholas D.; Huang, Dehua; Tehrani, Lida; Wang, Bowei; Anderson, Jeffrey; Brodkin, Jesse; Chung, Janice; Jiang, Xiaohui; King, Christopher; Munoz, Benito; Varney, Mark A.; Prasit, Petpiboon; Cosford, Nicholas D. P. Discovery of Novel Heteroarylazoles That Are Metabotropic Glutamate Subtype 5 Receptor Antagonists with Anxiolytic Activity.
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Abbas, Sabiha; Bhoumik, Anindita; Dahl, Russell; Vasile, Steve.; Cosford, Nicholas D. P.; Ronai, Ze'ev. Preclinical Studies of Celastrol and Gambogic Acid in Melanoma. Clin. Cancer Res., 2007, 3, 6769-6778. Johnston, Paul A.; Phillips, Jennifer; Shun, Tong Ying; Shinde, Sunita; Lazo, John S.; Huryn, Donna M.; Myers, Michael C.; Ratnikov, Boris I.; Smith, Jeffrey W.; Su, Ying; Dahl, Russell; Cosford, Nicholas D.P.; Shiryaev, Sergey A.; Strongin, Alex Y. HTS Identifies Novel and Specific Uncompetitive Inhibitors of the Two-Component NS2B-NS3 Proteinase of West Nile Virus.
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Grant Daniel; Dahl Russell; Cosford, Nicholas D. P. Rapid Multistep Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence.
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Rao, Tadimeti S.; Adams, Pamala B.; Correa, Lucia D.; Santori, Emily M.; Sacaan, Aida I.; Reid, Richard T.; Cosford, Nicholas D. P. Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist.
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Sidique, Shyama; Ardecky, Robert; Su, Ying; Narisawa, Sonoko; Brown, Brock; Millán, José Luis; Sergienko, Eduard; Cosford, Nicholas D. P. Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).
Talent
www.sanfordburnham.org, 23 Aug 2014 [cached]
Nicholas Cosford, Ph.D.
Professor, NCI-Designated Cancer Center
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Dr. Cosford's laboratory uses medicinal chemistry, chemical biology, rational drug design and microfluidic approaches to develop small-molecule modulators of cell death, survival and growth signaling pathways, for use as novel therapeutic agents to treat cancer, neurodegenerative and psychiatric disorders, and orphan diseases.
Graduate School Faculty
www.sanfordburnham.org, 23 Aug 2014 [cached]
Nicholas Cosford, Ph.D.
Professor, NCI-Designated Cancer Center Cell Death and Survival Networks Program
Dr. Cosford's laboratory uses medicinal chemistry, chemical biology, rational drug design and microfluidic approaches to develop small-molecule modulators of cell death, survival and growth signaling pathways, for use as novel therapeutic agents to treat cancer, neurodegenerative and psychiatric disorders, and orphan diseases.
Chemistry Team
www.sanfordburnham.org, 19 Nov 2011 [cached]
Nick Cosford, Ph.D.
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Nicholas Cosford, Ph.D.
Associate Professor, Director of Medicinal Chemistry
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Dr. Nick Cosford directs the medicinal chemistry laboratory at Sanford-Burnham's La Jolla site. Dr. Cosford was Project Manager for the CPCCG during the MLSCN Phase and is intimately familiar with the Network operations and goals. He is a medicinal chemist with more than 15 years experience in hit-to-lead optimization, including 13 years in the biopharmaceutical sector. At Sibia Neurosciences and Merck Research Laboratories, Dr. Cosford successfully led multiple projects from screening hits through to clinical candidates. His accomplishments to date have led to 19 issued patents, 25 patent applications pending and 44 peer reviewed publications.
Nicholas Cosford, ...
www.sanfordburnham.org, 23 Dec 2013 [cached]
Nicholas Cosford, Ph.D.
Associate Professor, NCI-Designated Cancer Center Apoptosis and Cell Death Research Program
ncosford@sanfordburnham.org
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