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Dr. Matthew D. Smyth

Assistant Professor, Pediatric Neurosurgery, Director, Pediatric Epilepsy Surgery Program

St. Louis Children's Hospital

Direct Phone: (314) ***-****       

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St. Louis Children's Hospital

One Children's Place

St. Louis, Missouri 63110

United States

Company Description

St. Louis Children's Hospital has provided specialized care for children for more than 130 years. US News & World Report ranks St. Louis Children's among the best pediatric hospitals in the nation. In 2015 the hospital received the Magnet re-designation f ... more

Find other employees at this company (1,257)

Background Information

Employment History

Associate Professor

Washington University


Membership Committee Chairman
American Society of Pediatric Neurosurgeons

Center Member
Children's Discovery Institute




Washington University

medical doctorate degree

University of California , San Francisco

Web References (54 Total References)

The Sturge-Weber Syndrome Community Canada [cached]

Matthew D. Smyth, M.D. St. Louis Children's Hospital One Children's Place, Suite 4E St. Louis, MO 63110

Matthew D. Smyth, ... [cached]

Matthew D. Smyth, MD Assistant Professor, Pediatric Neurosurgery Director, Pediatric Epilepsy Surgery Program St Louis Children's Hospital

Meet the Team Cleft Palate and Craniofacial Team - St. Louis Children's Hospital [cached]

Matthew D. Smyth, MD, Neurosurgeon

Meet the Pediatric Surgical Services Team - St. Louis Children's Hospital [cached]

Matthew Smyth, MD

Pediatric Ophthalmology

Trauma-Induced Epilepsy May Be Prevented By Cooling The Brain Following Injury | [cached]

"Traumatic head injury is the leading cause of acquired epilepsy in young adults, and in many cases the seizures can't be controlled with medication," says senior author Matthew Smyth, MD, associate professor of neurological surgery and of pediatrics at Washington University School of Medicine in St. Louis.

Smyth has been exploring the possibility of using cooling to prevent seizures or reduce their severity.
"Warmer brain cells seem to be more electrically active, and that may increase the likelihood of abnormal electrical discharges that can coalesce to form a seizure," Smyth says. "Cooling should have the opposite effect."
Smyth and colleagues at the University of Washington and the University of Minnesota test potential therapies in a rat model of brain injury.
The study is the first to reduce injury-related seizures without drugs, according to Smyth, who is director of the Pediatric Epilepsy Surgery program at St. Louis Children's Hospital.
"Our results show that the brain changes that cause this type of epilepsy happen in the days and weeks after injury, not at the moment of injury or when the symptoms of epilepsy begin," says Smyth. "If clinical trials confirm that cooling has similar effects in humans, it could change the way we treat patients with head injuries, and for the first time reduce the chance of developing epilepsy after brain injury."
Smyth and his colleagues have been testing cooling devices in humans in the operating room, and are planning a multi-institutional trial of an implanted focal brain cooling device to evaluate the efficacy of cooling on established seizures.

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