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This profile was last updated on 12/5/2016 and contains contributions from the  Zoominfo Community.

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Wrong Mary Digan?

Mary Ellen Digan

Senior Reseach Investigator

Novartis AG

HQ Phone:  +41 61 696 95 11

Direct Phone: (617) ***-****direct phone

Email: m***@***.com

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I agree to the Terms of Service and Privacy Policy. I understand that I will receive a subscription to ZoomInfo Community Edition at no charge in exchange for downloading and installing the ZoomInfo Contact Contributor utility which, among other features, involves sharing my business contacts as well as headers and signature blocks from emails that I receive.

Novartis AG

Lichtstrasse 35

Basel, Basel-City,4056

Switzerland

Company Description

Located in East Hanover, NJ, Novartis Pharmaceuticals Corporation is an affiliate of Novartis which provides innovative healthcare solutions that address the evolving needs of patients and societies. Headquartered in Basel, Switzerland, Novartis offers a diver... more

Find other employees at this company (69,293)

Background Information

Employment History

Marketing Analyst Manager

Emerald Marketing & Communications Times Square


Web References(1 Total References)


eln.slas.org

James A. Wells, along with fellow innovators Haian Fu of Emory University and Mary Ellen Digan of Novartis, are doing just that.
That seemingly simple overall sentiment has stemmed a robust career for Digan, who has come at the question from different angles, vantage points and methods. Trained as a Drosophila geneticist in molecular, cellular and developmental biology, she went on to work in the yeast, Pichia pastoris, on its genetics and protein expression before landing at the Novartis Institutes for Biomedical Research (NIBR). "It is an exciting time not only for the understanding of basic biology but also for high-throughput screening where people are starting to move toward more complex cellular models," she offers. "Our understanding of all the previous years of work has built to where we're now able to work in a more complex world." At the Center for Proteomic Chemistry (CPC) at NIBR, Digan designs screens and cell-based assays to discover low molecular weight inhibitors of different protein-protein interactions of therapeutic importance. CPC collaborates closely with all of NIBR's departments, applying the suitable combination of lead finding approaches to each drug discovery project. These include high- and medium-throughput screening, structural biology, fragment-based drug discovery, biophysics and various in silico approaches. CPC is the steward of the Novartis Compound Bank, a collection of over one million chemical compounds. In the SLAS Webinar, Digan will share basic information on various methods to interrogate protein-protein interactions in cells and then hone in on specific examples from Novartis. Digan will continue discussion of these methods with an in-depth example of assays employing BacMam, which uses viral insect particles to deliver and express genes in mammalian cells with minimum effort and toxicity. "BacMam vectors don't replicate or integrate in mammalian cells so, in general, they are biosafety level 1," Digan states. "That's really handy because screening labs are full of moving parts and people so if you can lower biosafety, that's good. BacMam vectors also offer the ability to titrate expression and maximize sensitivity of BRET2 assays. "It is my hope that cell biologists, or anyone interested in pathway biology or protein-protein interactions, will start to think about all of the things you can do with BRET2 and consider BacMam a versatile tool for many cell-based assays in addition to protein-protein interactions," Digan concludes. Mary Ellen Digan, Ph.D. Senior Research Investigator I Center for Proteomic Chemistry


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