Lloyd Kasper, M.D.
Lloyd Kasper, M.D.,
Professor of Medicine, Microbiology and Immunology, Geisel School of Medicine at Dartmouth College
Dr. Lloyd Kasper has been actively involved for many years in basic and applied neuroimmunology supported by research grants from the National Institutes of Health, March of Dimes, National Multiple Sclerosis Society and industry.
has published extensively on the immunology of the obligate intracellular parasite, Toxoplasma gondii, having identified critical antigens and immune pathways that are involved in disease pathogenesis.
Some of these parasite antigens have been patented and extensively utilized by industry to develop neonatal screening for toxoplasma infection in the US and Europe.
He established and was the long-time Director of the Dartmouth MS Center that serves an MS population of >1500 patients in northern New England.
basic research interests in MS are related primarily to understanding disease pathogenesis, the role of specific regulatory populations elicited by current and novel therapies, and the role of the gut microbiome in the regulation of CNS demyelination.
The National Multiple Sclerosis Society
and industry have awarded multiple grants to him to support this work.
has been PI and co-investigator for NIH
supported clinical trials in MS including anti-CD40L (CD154), CombiRx, estriol plus glatiramer and CTLA4-Ig.
He has served as an advisor for industry (Biogen Idec, Novartis, Genzyme, Sanofi, Teva Neuroscience, Mederex, Centocor, Bayer Healthcare, EMD Serono, ONO Pharmaceuticals, Genentech) on clinical and research protocol development for a number of clinical trials in MS including rituximab, ocrilizumab, alumtuzumab, daclizumab, ONO-4641, anti-IL12p40, lacquinimod, anti-CD40, CTLA-4Ig, TACI-Ig, and FTY-720.
has served in ad hoc, permanent and chairperson positions on NIH
and NMSS study section.
has organized three Keystone symposia including Opportunistic Infections
in AIDS, Translational Medicine in Autoimmunity and most recently the Role of the Gut Microbiome: Effector/Regulatory Networks that was held in February 2013.
has authored over 175 research and clinical articles related to his
basic research interests in immunology and clinical expertise in multiple sclerosis.