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2015-02-11T00:00:00.000Z

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Wrong Laurie Gesell?

Dr. Laurie Gesell Beth

Medical Director

University of Cincinnati

HQ Phone: (513) 556-6000

Email: l***@***.edu

University of Cincinnati

McMicken Commons 2600 Clifton Avenue

Cincinnati, Ohio 45221

United States

Company Description

The University of Cincinnati offers students a balance of educational excellence and real-world experience. Each year, this urban, public, research university graduates 5,000 students, adding to more than 200,000 living alumni around the world. UC is the ... more

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Background Information

Employment History

President
UNDERSEA AND HYPERBARIC MEDICAL SOCIETY INC

Cancer Specialist
Brain Radionecrosis Center

Medical Director , Division of Hyperbaric Medicine and Wound Management
Aurora Medical Group

Affiliations

Board Member
UNDERSEA AND HYPERBARIC MEDICAL SOCIETY INC

Founding Member
2006 Scientific Program Committee

Active Member of the Disaster Medicine Assistance Team
Disaster Medical System

Fellow
American College of Emergency Physicians

Education

MD

medical degree

UMDNJ

medical degree

University of Medicine & Dentistry of New Jersey

undergraduate degree

Skidmore College

Web References (70 Total References)


Hyperbaric Oxygenation - New strategy for attacking brain tumors

www.richmond-hyperbaric.com [cached]

"These patients don't have a whole lot of options," says Dr. Laurie Gesell, director of the Division of Hyperbaric Medicine in the UC's Department of Emergency Medicine, who's leading the study.

"They have a devastating disease, they have a brain tumor, which has significant morbidity associated with it," she said. "They then get treated aggressively to try to treat that horrific disease.
"They end up with a complication that can have just as much significant morbidity or mortality as the disease itself."
Gesell is working with University Hospital's new Brain Radionecrosis Center, the only facility in the country participating in the two-year, $450,000 study. It's funded by the National Cancer Institute, through the National Institutes of Health.
Gesell explains the problem this way.
When patients are diagnosed with brain tumors, typical treatment includes radiation therapy, chemotherapy or surgery. That often leads to a usually treatable brain radiation injury. Soft-tissue injury to the brain begins with swelling that sometimes disappears without treatment. So when it's first diagnosed, doctors might just watch it, Gesell says.
If patients start showing clinical symptoms they're put on steroids. "If the steroids don't control the progressive injury pattern, the dose of the steroids will increase and increase and increase," Gesell says. "But there are complications and side effects from the steroids, which can be just as devastating for individuals' health," she said.
...
Although more study needs to be done to determine how many people develop side effects from brain radiation therapy, about 200,000 people a year in the United States are diagnosed with either primary or secondary brain tumors, says Gesell.
"Physicians have become more aggressive in treating these brain tumors in order to get better outcomes for their patients," Gesell says.
"That also means that the incidence of problems and complications from the radiation has also increased."
Knowing that hyperbaric oxygen treatment is the standard of care for conditions such as carbon monoxide poisoning, hard-to-heal wounds, crush injuries, decompression sickness and a host of other conditions, doctors at University began using hyperbaric treatments on the patients with the conciliation -- known as brain radionecrosis -- about six years ago.
The treatment involves placing the patient in a pressure chamber and having the patient breathe pure oxygen at a pressure similar to being under 33 to 66 feet of seawater, Gesell says. Each treatment lasts 1½ hours. Treatments are repeated every day for one to three months.
Preliminary results are promising, Gesell says. In many patients damaged tissues have been healed completely.
In about 86 percent of cases, doctors were able to stabilize or decrease the steroids dosage. In some cases, patients even were able to stop taking steroids.
MRIs showed that the disease had stabilized or improved in 78 percent of patients, Gesell says. Armed with the results, doctors applied for the funding for the current study.
Doctors believe the pure oxygen at increased pressure causes new blood vessels to grow in injured tissue, but no one is sure exactly how, says Gesell.
Gesell and her team of researchers at UC and the Neuroscience Institute set up the Brain Radionecrosis Center to study not only how well hyperbaric oxygen therapy works, but also the mechanism that enables it to work.
...
The initial study, known as a pilot trial, will involve only 30 patients, but researchers have already been receiving calls from all over the nation, Gesell says.


Rapid Recovery Hyperbarics : Introduction

www.rapidrecoveryhyperbarics.net [cached]

"These patients don't have a whole lot of options," says Dr. Laurie Gesell, director of the Division of Hyperbaric Medicine in the UC's Department of Emergency Medicine, who's leading the study.

"They have a devastating disease, they have a brain tumor, which has significant morbidity associated with it," she said. "They then get treated aggressively to try to treat that horrific disease.
"They end up with a complication that can have just as much significant morbidity or mortality as the disease itself."
Gesell is working with University Hospital's new Brain Radionecrosis Center, the only facility in the country participating in the two-year, $450,000 study. It's funded by the National Cancer Institute, through the National Institutes of Health.
Gesell explains the problem this way.
...
So when it's first diagnosed, doctors might just watch it, Gesell says.
If patients start showing clinical symptoms, they're put on steroids.
"If the steroids don't control the progressive injury pattern, the dose of the steroids will increase and increase and increase," Gesell says.
"But there are complications and side effects from the steroids, which can be just as devastating for individuals' health," she said.
...
Although more study needs to be done to determine how many people develop side effects from brain radiation therapy, about 200,000 people a year in the United States are diagnosed with either primary or secondary brain tumors, says Gesell.
"Physicians have become more aggressive in treating these brain tumors in order to get better outcomes for their patients," Gesell says.
"That also means that the incidence of problems and complications from the radiation has also increased."
Knowing that hyperbaric oxygen treatment is the standard of care for conditions such as carbon monoxide poisoning, hard-to-heal wounds, crush injuries, decompression sickness and a host of other conditions, doctors at University began using hyperbaric treatments on the patients with the conciliation -- known as brain radionecrosis -- about six years ago.
The treatment involves placing the patient in a pressure chamber and having the patient breathe pure oxygen at a pressure similar to being under 33 to 66 feet of seawater, Gesell says. Each treatment lasts 1 1/2 hours.
Treatments are repeated every day for one to three months.
Preliminary results are promising, Gesell says. In many patients, damaged tissues have been healed completely.
In about 86 percent of cases, doctors were able to stabilize or decrease the steroids dosage. In some cases, patients even were able to stop taking steroids.
MRIs showed that the disease had stabilized or improved in 78 percent of patients, Gesell says.
Armed with the results, doctors applied for the funding for the current study.
Doctors believe the pure oxygen at increased pressure causes new blood vessels to grow in injured tissue, but no one is sure exactly how, says Gesell.
Gesell and her team of researchers at UC and the Neuroscience Institute set up the Brain Radionecrosis Center to study not only how well hyperbaric oxygen therapy works, but also the mechanism that enables it to work.
...
The initial study, known as a pilot trial, will involve only 30 patients, but researchers have already been receiving calls from all over the nation, Gesell says.


Laurie B. Gesell, MD, FACEP, ...

www.courses-uhms.org [cached]

Laurie B. Gesell, MD, FACEP, FUHM - Medical Director, Division of Hyperbaric Medicine and Wound Care, Aurora Medical Group, Milwaukee, WI; Past President, Undersea & Hyperbaric Medical Society

...
Laurie Gesell, MD


Laurie B. Gesell, MD, FACEP, ...

www.courses-uhms.org [cached]

Laurie B. Gesell, MD, FACEP, FUHM Medical Director, Division of Hyperbaric Medicine and Wound Care, Aurora Medical Group, Milwaukee, WI; Past President, Undersea & Hyperbaric Medical Society


Laurie B. Gesell, MD, FACEP, ...

www.courses-uhms.org [cached]

Laurie B. Gesell, MD, FACEP, FUHM Medical Director, Division of Hyperbaric Medicine and Wound Care, Aurora Medical Group, Milwaukee, WI; Past President, Undersea & Hyperbaric Medical Society

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