affiliate assistant scientist Division of Neuroscience
http://www.ico2006.com/Contact_us.htm where this paper was given by Kevin Grove
...Neuroscientist Kevin Grove of the US-based Developmental Obesity Research Consortium said Friday that studies on primates showed foetuses given a high-fat diet had high rates of fatty liver disease, abnormal brain development and insulin resistance."Even if mothers were genetically lean, all of the babies were predisposed to becoming obese and diabetic because of the damage we saw in the liver," Grove told the 10th International Congress on Obesity in Sydney.Grove said research at the Oregon Health and Science University showed a calorie-rich diet, not just one high in fat, was dangerous to foetuses.He
was concerned that in the United States, where two-thirds of the population was overweight, a generation of babies was being born with liver damage that would predispose them to becoming obese and diabetic.
Non-alcoholic fatty liver disease had increased three-fold in the US in recent years, Grove
believed metabolic abnormalities in many babies were not being detected.
"We are predicting an enormous number of kids that are undiagnosed because they actually haven't developed full liver disease to the clinical level," he
said the abnormal liver function meant they were at greater risk of problems including damage to circuits in the brain that controlled appetite.
"We know that these babies are being born abnormal," he
Appetite control was a complex issue and high-calorie diets might damage it in a number of ways, Grove
"With the circuits that are developing in the brain, [a calorie-dense diet] may end up programming that brain to seek out tasty foods that aren't healthy, or may make them feel more lethargic, so they won't feel like getting up and working out as much," he
said the findings did not mean babies of mothers on calorie-rich diets were certain to become obese or diabetic, just that they were more likely to develop the conditions later in life.Grove
next step would be to see whether feeding obese non-human primates a healthy diet could prevent the development of fatty liver disease and problems in the brain's circuits controlling appetite.
"That could give obstetricians and paediatricians an immediate clinical application so they can recommend a specific diet to pregnant women to prevent a lot of these diseases," he
The three sentenced on Tuesday include the president of SHAC