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Director of the Pediatric Gastrointestinal and Nutrition Laboratory
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800 West Baltimore Street
About The University of Maryland: The highly regarded public University of Maryland was founded in 1856 and has the distinction of being the flagship institution of the University System of Maryland. With nearly 38,000 students, it is the largest university in... more.
Karoly Horvath, MD
Gastroenterology - Pediatric, Orlando, FL Photo of Karoly Horvath, MD Karoly Horvath, MD, PhD, joined the Arnold Palmer Hospital for Children Center for Pediatric Digestive Health and Nutrition in 2011. Prior to moving to Orlando, Dr. Horvath served as the director of Nemours Children Celiac Center and the gastroenterology laboratory in A.I. DuPont Hospital for Children. He is board certified in pediatric gastroenterology. Additionally, Dr. Horvath is a published author with numerous published articles and book chapters in a variety of gastroenterology topics. He has dedicated many years to gastroenterology research and has taught at the University of Maryland and Hahnemann University in Philadelphia.
The interest in secretin began in 1996, when Dr. Karoly S. Horvath, director of the pediatric gastrointestinal and nutrition laboratory at the University of Maryland, Baltimore, administered intravenous secretin while examining an autistic child with chronic diarrhea.
Dr. Horvath and associates gave secretin while assessing gastrointestinal complaints in two other autistic children, and reported "a dramatic improvement in their behavior, manifested by improved eye contact, alertness, and expansion of expressive language," in the next several weeks along with relief of gastrointestinal symptoms.
Interest in secretin began in 1996 when Dr. Karoly S. Horvath, director of the pediatric gastrointestinal and nutrition laboratory at the University of Maryland, Baltimore, administered intravenous secretin while examining an autistic child with chronic diarrhea.
Dr. Horvath gave secretin while assessing gastrointestinal complaints in two other children with autism and reported dramatic improvement in their behavior, manifested by improved eye contact, alertness, and expansion of expressive language in the next several weeks along with relief of gastrointestinal symptoms. Secretin may influence blood flow in the brain and this may be the reason it has effects on the condition of autism. Dr. Horvath reports that brain imaging studies in one of his cases showed a marked postinfusion increase in cerebral blood flow in areas of the brain affecting language and social behavior. Secretin may also activate receptors for a related hormone, vasoactive intestinal polypeptide, which is more widely distributed in the brain. Dr. Horvath speculates that a single dose of secretin is unlikely to change the brain of a child with autism, but it could possible trigger a cascade of other neuropeptides in some children and in this way have more lasting effects. Dr. Horvath will shortly finish data collection on a study of secretin use in 30 children.
The research of Horvath (University of Maryland) and Buie (Harvard) found carbohydrate malabsorption in ASD children, while the work of Shaw reports gut microorganisms to be the culprit in ASD.
Dr. Karoly Horvath and his colleagues at the Department of Pediatrics at the University of Maryland, and Dr. Timothy Buie, a Pediatric Specialist at Harvard/Mass General Hospital, found that carbohydrate malabsorption may be the cause of many gastrointestinal symptoms seen in autistic children including abdominal pain, gas, bloating, and chronic diarrhea or loose stools.
* Karoly Horvath, M.D., Ph.D., Associate Professor, Pediatric Gastroenterologist, Co-Director, Center for Celiac Research, University of Maryland, Baltimore, Maryland
Afternoon session with a focus on "The Celiac Diet":