"Women who have this syndrome have a staggeringly high risk of endometrial cancer -- about 40 to 60 percent," said study author Dr. Karen Lu, an associate professor of gynecologic oncology at the University of Texas M.D.
Anderson Cancer Center
"Their risk of ovarian cancer is also quite high -- about 10 to 12 percent."
In general, women without Lynch syndrome have between a 1 percent and 3 percent lifetime risk of endometrial or ovarian cancer, according to Lu
"Prior to this time, physicians'' groups have not been able to recommend undergoing prophylactic hysterectomy, but this study provides definitive data that tells patients that they can prevent that risk of cancer by undergoing a hysterectomy," said Lu
"We know we can decrease mortality by having yearly colonoscopy, but there''s a lot less info for endometrial cancer, so we don''t know if screening would be helpful," said Lu
SOURCES: Karen Lu, M.D., associate professor, gynecologic oncology, University of Texas M.D.