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Cambridge, Cambridgeshire CB2 3EG
The Cambridge Canadian Studies Initiative (CCSI) was founded in 2004, creating a new focal point for Canadian Studies at the University of Cambridge. The CCSI was widely welcomed as reestablishing an institutional presence for Canadian Studies at Cambri ... more
Consultant Physician and Clinical Pharmacologist and Associate Lecturer
Cardiovascular Clinical Trials Office, Cambridge University Hospitals NHS Foundation Trust
Scientific Advisory Board, Wellcome Trust CRF, ACRC
Vice Chair, Cambridge Central Ethics Committee
Health Research Authority
Dr Joseph Cheriyan - EMIT
'Tomato pillâ€™ improves function of blood vessels - Experimental Medicine and Immunotherapeutics (EMIT)
Endothelial dysfunction occurs when the inner lining of the blood vessels fails to dilate or constrict properly, and is believed to be involved in the development of atherosclerosis.
In a double-blind trial, Dr Cheriyan and colleagues randomized 36 cardiovascular disease patients treated with statin drugs and an equal number of healthy control subjects to receive 7 milligrams oral lycopene per day or a placebo for two months.
Forearm blood flow assessments of endothelium dependent and independent vasodilation, and basal nitric oxide synthase activity were conducted before and after treatment.
Endothelial-dependent vasodilation improved by 53% among those in the cardiovascular disease group who received lycopene.
Although it averaged 30% lower in cardiovascular disease patients in comparison with healthy volunteers at the beginning of the study, by the end of the treatment period the endothelial-dependent vasodilation of participants with cardiovascular disease who received lycopene was comparable to that of the healthy subjects at the study's onset.
"We've shown quite clearly that lycopene improves the function of blood vessels in cardiovascular disease patients," Dr Cheriyan announced.
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