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This profile was last updated on 8/1/00  and contains information from public web pages.

Dr. John J. Docherty

Wrong Dr. John J. Docherty?
 
Background

Employment History

Board Memberships and Affiliations

17 Total References
Web References
2000 National Causus
www.aacbnc.com, 1 Aug 2000 [cached]
Dr. John J. Docherty (3) Professor & Chairman, Dept. Microbiol.& Immunol., Northeastern OH Univ., College of Medicine, 4209 State Route 44, P.O.Box 95, Rootstown, OH 44272, Tel: 330-325-6133, Fax: 330-325-5914, Jjd@neoucom.edu
Dr. John J. Docherty (3) ...
www.aacbnc.com, 22 June 2000 [cached]
Dr. John J. Docherty (3) Professor & Chairman, Dept. Microbiol.& Immunol., Northeastern OH Univ., College of Medicine, 4209 State Route 44, P.O.Box 95, Rootstown, OH 44272, Tel: 330-325-6133, Fax: 330-325-5914, Jjd@neoucom.edu
herpes
www.menstuff.org, 11 Jan 2011 [cached]
The research, which is being directed by Dr. John J. Docherty of Northeastern Ohio Universities College of Medicine, was presented during a poster session here at the Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology.
John Docherty, Ph.D., a ...
www.news.herpes-nomore.com [cached]
John Docherty, Ph.D., a professor of microbiology and immunology at Northeastern Ohio Universities College of Medicine, has conducted a study on the effects of red wine on herpes simplex I (the virus that causes cold sores). He believes that higher concentrations of resveratrol than found in red wine were needed to effective against the virus.
ASM News Vol 66, Num 12,  December 2000, Red Wine, Sea Sponge are Sources for Potential Drugs
newsarchive.asm.org, 1 Dec 2000 [cached]
Intrigued by reports that resveratrol inhibits DNA synthesis, John Docherty of the Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, and his colleagues tested the compound and several simple derivatives on various DNA viruses growing in cell cultures.
One resveratrol derivative, designated stil-5, is particularly effective against herpes simplex viruses (HSV)-1 and -2, killing over 99.9% of these viruses in culture. Resveratrol and its derivatives appear to knock out two crucial regulatory proteins, ICP-4 and ICP-27, during the first stage of the viral replication process, halting further activity. "It is quite potent," Docherty says. "Frankly, it kind of surprised us when we saw it. However, realizing that in nature resveratrol likely wards off infectious agents that alight on grapes, the greater surprise is that no one recognized or tested its broader antimicrobial properties sooner, he adds.
Since millions of people consume resveratrol in wine and other similar constituents of wines and other foods everyday, Docherty says that the compound and its derivatives are unlikely to be toxic. But individuals who suffer from herpesvirus infections should not expect to be drinking away their infection-related problems anytime soon, according to Docherty. Instead, he envisions a topical gel or cream that would be applied directly to herpetic lesions.
While Docherty and his colleagues are focusing on a single natural product and a set of derivatives, Peter McCarthy and his colleagues at the Harbor Branch Oceanographic Institution (HBOI) in Fort Pierce, Fla., are looking much more broadly at a collection of some 27,000 natural specimens amassed during 15 years of ocean scavenging.
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