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This profile was last updated on 6/6/15  and contains information from public web pages and contributions from the ZoomInfo community.

Professor of Pediatrics

Phone: (514) ***-**** ext. *****  
McGill University
1205 Docteur Penfield Avenue
Montreal , Quebec H3A 1B1
Canada

Company Description: The McGill University Health Centre (MUHC) is a comprehensive academic health institution with an international reputation for excellence in clinical programs,...   more
Background

Employment History

  • Jack Cole Professor In Pediatric Oncology
    McGill University
  • Researcher In the Cancer Axis
    Research Institute of the McGill University Health Centre at the Montreal Children's Hospital
  • Associate Professor , Department of Medicine
    Henderson Research Centre
  • Assistant Professor
    Henderson Research Centre
  • Researcher
    Research Institute of the Montreal Children's Hospital of the MUHC
  • Readers Select MUHC Researcher
    Québec Science magazine
  • Jack Cole Chair In Pediatric Hematology and Oncology As Well As Associate Professor, Department of Pediatrics
    Montreal Children's Hospital
  • Scientist
    Montreal Children's Hospital
  • Assistant Professor
    Henderson Research Centre at McMaster University

Board Memberships and Affiliations

Education

  • MD
  • PhD , tumor biology
    Ludwik Hirszfeld Institute of Immunology
  • Medical Academy
88 Total References
Web References
Invited Speakers | MISAM 2013
misam.mcgill.ca, 6 June 2015 [cached]
Janusz Rak, MD/PhD; MUHC's Montreal Children's Hospital Research Institute, McGill University, Canada
Montreal Neurological Institute and Hospital - News item
www.mni.mcgill.ca, 11 Feb 2009 [cached]
The team of Dr. Janusz Rak, of the Research Institute of the McGill University Health Centre (MUHC) at the Montreal Children's Hospital, including Dr. Khalid Al-Nedawi and Brian Meehan, has just discovered a new mechanism that tumours use to stimulate the growth of the blood vessels that feed them.
...
But this new discovery is much more targeted and represents a new direction in terms of therapy," said a delighted Dr. Rak.
... to starve tumours In fact, a family of molecules derived from annexin V seems to effectively fight this process and ultimately may help "starve" the tumour. "The molecule we used is effective both in vitro and in vivo. It prevents the formation of new blood vessels in mice with cancer and therefore strongly inhibits tumour growth," explained Dr. Rak.
...
Dr. Janusz Rak Dr. Janusz Rak is a researcher in the Cancer Axis at the Research Institute of the McGill University Health Centre at the Montreal Children's Hospital. He is also a Jack Cole Professor in Pediatric Oncology at McGill University.
...
Media clip: interview with Dr. Janusz Rak
See also:
Janusz Rak - La Fondation Cole | The Cole Foundation
colefoundation.ca, 1 Jan 2013 [cached]
Janusz Rak
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Janusz Rak
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Dr. Janusz Rak has held the Jack Cole Chair in Pediatric Oncology and Hematology since April of 2006, when he joined McGill as an Associate Professor in the Department of Pediatrics and an Associate Member of the Division of Experimental Medicine (Department of Medicine). He is also a researcher in the Cancer Axis at the Research Institute of the McGill University
Health Centre at the Montreal Children's Hospital. Dr. Rak graduated from the Medical Academy in Wroclaw, Poland, in 1980. He received his PhD in tumor biology from the Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, in 1986 for studies on transplantable tumor models as predictors of treatment efficacy in cancer, changes in tumor-host interactions resulting from anti-cancer treatment, and interactions between tumor cells and the vasculature in the course of cancer metastasis. In 1988, as a recipient of the Fulbright-Hays Postdoctoral Scholarship, he joined the Michigan Cancer Foundation in Detroit, Michigan, where he worked on tumor cell heterogeneity, tumor cell interactions in metastasis, alterations in cancer cell glycosylation, and the role of ras oncogene in tumor progression. Dr. Rak pursued similar areas of research during his subsequent postdoctoral work with Dr. Robert S. Kerbel at the University of Toronto.
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In 2000, Dr. Rak joined the Henderson Research Centre at McMaster University, where he held the title of Assistant Professor affiliated with the Department of Medicine and the Division of Oncology until coming to McGill.
Dr. Rak's research revolves around understanding the role of the vascular system in the development, progression, and responsiveness to therapy of human cancers, particularly those affecting children. In fact, it is now known that pediatric malignancies, including leukemia, are dependent on processes of vascular growth (angiogenesis), as blood vessels 'communicate' with and stimulate cancer cells in a number of ways. Dr. Rak pioneered studies on the interrelationship between genetic tumor progression (i.e. the action of oncogenes, tumor suppressor genes, and aberrant intracellular signaling pathways) in the regulation of angiogenic and procoagulant properties of cancer cells and their related capacity to use the vascular system as a vehicle for tumor growth and spreading. His laboratory is studying the role of molecules such as tissue factor (TF), vascular endothelial growth factor (VEGF), and thrombospondin (TSP-i) in these processes. Trie lab also studies interactions between cancer cells, their associated stroma, blood vessels, and blood in generating conditions for aggressive tumor growth. In so doing, they concurrently explore the role of drugs targeting oncogenes (targeted agents), blood vessels (antiangiogenic agents), and the coagulation system (anticoagulants) in bringing such growth under control. Dr. Rak is also probing why traditional and novel treatments (e.g. antiangiogenesis) are sometimes ineffective in treating cancers (e.g. due to drug resistance), and he aims to find ways to use these agents more effectively. By better understanding how tumors interact with blood vessels, and how these interactions differ between malignancies affecting adults and children, Dr. Rak's research will hopefully lead to better treatment of cancers affecting children.
Henderson Research Centre - Thrombosis and Vascular Disease - Hamilton
www.hendersonresearchcentre.com, 11 Nov 2010 [cached]
Dr. Janusz Rak
Henderson Research Centre - Thrombosis and Vascular Disease - Hamilton
www.hendersonresearchcentre.com, 19 Nov 2007 [cached]
Dr. Janusz RakHenderson Research Centre - Thrombosis and Vascular Disease - Hamilton
...
Dr Janusz Rak graduated medicine and received his medical licence at the Medical Academy in Wroclaw, Poland.He received his PhD degree in tumor biology from the Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences in 1986 for studies on transplantable tumor models as predictors of treatment efficacy in cancer, changes in tumor-host interactions resulting from anti-cancer treatment, and interactions between tumor cells and the vasculature in the course of cancer metastasis.
In 1988, as a recipient of the Fullbright-Hays Postdoctoral Scholarship he joined the Michigan Cancer Foundation (MCF) in Detroit, Michigan, where he worked with Drs Fred and Bonnie Miller, and Gloria Heppner on tumor cell heterogeneity, tumor cell interactions in metastasis, alterations in cancer cell glycosylation and the role of ras oncogene in tumor progression.Some of these themes accompanied Dr Rak during his subsequent postdoctoral work with Dr Robert S. Kerbel at the University of Torono.
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Dr Rak joined the Henderson Research Centre in 2000 as an Assistant Professor affiliated with the Department of Medicine and the Division of Oncology, McMaster University.His laboratory is currently pursuing studies on the relationship between angiogenesis and various activities of the hemostatic system both, in cancer and in other 'angiogenesis -dependent' diseases.
Dr Rak is an author or co-author of over 70 publications, recipient of peer-reviewed grants from the National Cancer Institute of Canada (NCIC) and Natural Sciences and Engineering Research Council of Canada (NSERC), and a reviewer for several research journals (Lancet, Journal of Cell Science, Cancer Research, International Journal of Cancer and others).
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