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2003-02-26T00:00:00.000Z

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Background Information

Employment History

Deputy Director, the Research
National Center for Toxicogenomics

Deputy Director
NCT

Chemist
National Institute of Environmental Health Sciences

Deputy Director
National Institute of Environmental Health Sciences

Web References (11 Total References)


Cosmetic, Toiletry,and Fragrance Association (CTFA)

www.ctfa.org [cached]

The seminar featured Dr. James Selkirk, deputy director of the National Institute of Environmental Health Sciences (NIEHS) National Center for Toxicogenomics Research; Dr. Harvey Clewell, Environ International Corporation; and Dr. Jorge Naciff, The Procter & Gamble Company.

...
Dr. Selkirk explained that the goal of the NIEHS is to develop sufficient data so that toxicogenomics can be used to predict the toxicity of chemicals.


PharmaLive

www.pharmalive.com [cached]

James Selkirk, National Center for Toxicogenomics, NIEHS


GNN - Articles

www.genomenewsnetwork.com [cached]

According to James Selkirk, a chemist at NIEHS and the Deputy Director of the NCT, the research is currently progressing in a two-phase manner.The first phase involves resequencing genes associated with cell cycle regulation and DNA repair.The genes studied at the EGP have already been sequenced elsewhere and are all fairly well known."We're not in the business of gene discovery," Selkirk emphasizes.The goal is a definitive catalogue of all the variations in these genes, which Selkirk says will "allow us to have closure on a given cellular pathway."The initial plan called for assessing 200 genes in a population of 500 anonymous individuals at an estimated cost of $200 million.But Selkirk says economies of scale resulting from high-throughput technologies using Applied Biosystems 3700 sequencers and improved computation have sharply reduced costs.So far, nearly 100 genes from 90 people have been resequenced at a cost of only about $10 million.In the second phase, EGP researchers will assess the major SNPs for their frequency in populations of people with environmentally-suspect diseases.Further down the line, links between SNP frequency, disease, and environmental exposures will be elucidated in multi-disciplinary toxicology and epidemiology studies.In a related effort, the EGP is also investigating the ethical, social, and legal issues raised by its findings.

Click here to see full chartCourtesy of NIEHS
...
Selkirk says the agenda at the newly formed National Center for Toxicogenomics revolves around a number of key goals.These include enhanced methods for assessing gene expression, developing an additional database relating microarrays and proteomics to environmental exposures, and improving mathematical paradigms to study protein function.Referring to chemical effects on gene expression, Selkirk says, "There's this huge kinetic process happening, a multitude of factors such as post-translational modification that guide the functionality of the protein.We don't think the available mathematical and computational tools can handle this amount of data."An additional challenge, he adds, is that environmentally induced biochemical cascades in the cell can be highly sensitive to temporal factors and dose.Changes in either of these parameters can exert a major influence on gene expression."We're talking about a monumental kinetic problem in biochemistry," Selkirk concedes.
The EGP's activities are centered in three locations.So-called 'intramural activities' are based at the NIEHS' facilities at Research Triangle Park, NC, and involve collaboration with the Lawrence Livermore National Laboratories, CA.A major agenda item for the intramural staff has been to confer with NIEHS and outside researchers to identify candidate genes for resequencing.


Data Explosion: Bringing Order to Chaos with Bioinformatics

www.schmidtwriting.com [cached]

According to James Selkirk, deputy director of the NCT, this "ToxChip" is being designed in cooperation with the NIEHS-funded Toxicogenomics Research Consortium, a group of five academic research centers plus the Microarray Center. The intention, he says, is to produce a chip containing a large number of genes thought to be relevant to the toxicity of environmental agents. "This should be something that is of wide interest to the microarray profiling public," Selkirk says.


CTFA | CTFA News, Issue 4, February 26, 2003

ctfa.activematter.com [cached]

The seminar featured Dr. James Selkirk, deputy director of the National Institute of Environmental Health Sciences (NIEHS) National Center for Toxicogenomics Research; Dr. Harvey Clewell, Environ International Corporation; and Dr. Jorge Naciff, The Procter & Gamble Company.

...
Dr. Selkirk explained that the goal of the NIEHS is to develop sufficient data so that toxicogenomics can be used to predict the toxicity of chemicals.

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