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(17 Total References)
Data Explosion: Bringing Order to Chaos with Bioinformatics
According to James Selkirk, deputy director of the NCT, this "ToxChip" is being designed in cooperation with the NIEHS-funded Toxicogenomics Research Consortium, a group of five academic research centers plus the Microarray Center.
The intention, he says, is to produce a chip containing a large number of genes thought to be relevant to the toxicity of environmental agents.
"This should be something that is of wide interest to the microarray profiling public," Selkirk says.
EHP 111-3, 2003: Not-So-Superfund: Growing Needs vs. Declining Dollars
But integrating SNP data with toxicogenomics is a long way off, says NCT deputy director James Selkirk.
"When the SNPs are identified in known genes, we can look to see how they affect specific genomic pathways," he says.
Phenotypic anchoring, says Selkirk
, is a technique that couples the unique gene expression patterns induced by chemical exposures to visible evidence of harm.
In this fashion, the gene expression patterns provide chemical-specific signatures for toxicological pathways and effects.
Ideally, the signatures should relate to expression profiles obtained at multiple dose levels, Selkirk
According to Selkirk
, NCT scientists are using genomic and proteomic tools to identify the biochemical pathways corresponding to therapeutic and toxic doses.
"We want to study both pathways so we know where and when they diverge, and how toxicity is manifested," Selkirk
Past Gordon Research Conference Proposals
James K. Selkirk, Deputy Director, National Center for Toxicogenomics, NIEHS
MDIBL > Courses and Conferences
8:30--James K. Selkirk, Ph.D., Deputy Director, The National Center for Toxicogenomics
World Trade Group - Summit Club
World Trade's Craig Eason spoke to Dr James Selkirk of the Institute of Environmental Health Science's National Centre for Toxicogenomics about the developments in this field of research, the development of a public knowledge database and the implications for understanding disease.
...Dr James Selkirk
NETWORKING - NEW WORLD BUSINESS PRINCIPLES
Craig Eason met with Thomas Power, a self-made entrepreneur, at the Institute of Director's office in Pall Mall to talk about what he
sees as a new world of social capitalism. >>read article (17/03/03) Dr James Selkirk