"Among relapsed lymphoma patients who then have a positive PET scan and who then go through autologous stem cell transplantation, the transplantation outcome is often very poor," said Jakub Svoboda, MD, third year fellow, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
"Most centers just use CT scans to assess patients' response to the chemotherapy," Dr. Svoboda
"But if you add the PET scan, it can help guide clinicians in deciding whether or not the patient should receive transplantation.
If the PET scan is positive, then the chance of the transplant having any meaningful clinical impact is low."
For this retrospective analysis, Dr. Svoboda
colleagues reviewed data on 19 patients with diffuse large B-cell lymphoma and 18 with Hodgkin's lymphoma, four with mantle cell, three with follicular and three with other lymphomas.
"From what we have seen, however, patients should probably have both a CT scan and a FDG-PET scan prior to receiving a transplant," Dr. Svoboda