Dr. Carney's memoir | The Story of Discovery of the Carney Triad | discovery-of-the-carney-triad.php
GIST Support International - Discovery of the Carney Triad
GIST Support International - logo
asked Dr. Aidan Carney
to describe how he
came to identify the syndrome of tumors now known as Carney triad, which affects young patients.
Dr. Carney, a pathologist, now retired but continuing his research activities, is an emeritus member of the Department of Laboratory Medicine and Pathology at the Mayo Clinic in Rochester, Minnesota.
special interests during his
career have included endocrine and gastrointestinal pathology, with a particular interest in syndromes.
The Story of Discovery
of the Carney Triad
by J. Aidan Carney, M.D., Ph.D., F.R.C.P.I., F.R.C.P.
Note that Dr. Carney's
name has also been attached to a different and unrelated disorder known as Carney complex or 'complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas.' Therefore, if you search PubMed, do not confuse the two similarly named syndromes.
The following quote is from the concluding paragraph of an editorial summary about Dr. Carney and his dedicated quest to understand the triad by fellow pathologist Henry D. Appelman, M.D. (Mayo Clinic Proceedings, 1999, 74:638-639).
, with intelligence and perseverance, recognized that not all gastrointestinal stromal tumors are the same and that there is more to them than simply determining the cell types within them or finding features that distinguish the benign ones from the malignant.
observed that a small group of them occurred in a specific clinical setting and that they had a peculiar clinical behavior.
scoured the literature for similar cases and tracked down the authors of most such reports with almost religious fervor to see if those cases were like his
The Aidan Carneys of this world are insightful and creative, and they force those of us who are neither to keep our eyes open, observe things carefully, and question dogma frequently.
The Carney triad is not so much a medical issue as it is a medical lesson."
By special permission of Dr. Carney
, Dr. Appleman, and the Mayo Clinic
Proceedings, the following two papers about Carney Triad are available on the GIST Support International website:
J. Aidan Carney
Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): natural history, adrenocortical component, and possible familial occurrence.
Proceedings 74(6): 543-552.