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Illana Gozes

Professor of Clinical Biochemistry

Tel Aviv University

HQ Phone:  (212) 742-9070

Direct Phone: +972 *-***-****direct phone

Email: i***@***.il

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I agree to the Terms of Service and Privacy Policy. I understand that I will receive a subscription to ZoomInfo Community Edition at no charge in exchange for downloading and installing the ZoomInfo Contact Contributor utility which, among other features, involves sharing my business contacts as well as headers and signature blocks from emails that I receive.

Tel Aviv University

39 Broadway Suite 1510

New York City, New York,10006

United States

Company Description

Founded in 1963, Tel Aviv University is one of Israel's foremost research and teaching universities. Located in Israel's cultural, financial and industrial heartland, Tel Aviv University is at the forefront of basic and applied research in a wide variety of sc...more

Background Information

Employment History

Associate Editor

Journal of Alzheimer's Disease


Director of Adams Super Center for Brain Studies

TAU Trust


Affiliations

Israel Brain Technologies

Board Member


The ADNP Kids Research Foundation

Neuroscientist


Israel Neuroscience Research Link

Board Member


The International Neuropeptide Society

Board Member


Institute for the Study of Aging , Inc.

Member of Scientific Advisory Board


Tel Aviv Universitys Sagol School of Neuroscience

Member


Massachusetts Institute of Technology

Weizmann Postdoctoral Fellow


Education

BSc

Tel Aviv University


PHD

Weizmann Institute


Ph.D

Tel Aviv University


PhD

Department of Human Molecular Genetics and Biochemistry

Sagol School of Neuroscience


Web References(183 Total References)


Israeli Scientific Advisory Board | Israel Brain Technologies

israelbrain.org [cached]

Prof. Ilana Gozes
Director, Adams Super Center for Brain Studies, Tel Aviv University


ABOUT - ADNP Kids Research Foundation

www.adnpfoundation.org [cached]

Illana Gozes, Ph.D.
6. Illana Gozes, PhD: Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Adams Super Center for Brain Studies and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel


In the News - CFTAU

www.cftau.org [cached]

Now, Prof. Illana Gozes - the Lily and Avraham Gildor Chair for the Investigation of Growth Factors, the director of the Adams Super Center for Brain Studies at the Sackler Faculty of Medicine, and a member of the Sagol School of Neuroscience at Tel Aviv University - has discovered that an important cell-maintenance process called autophagy is reduced in the brains of schizophrenic patients.
The findings, published this week in Nature's Molecular Psychiatry, advance the understanding of schizophrenia and could enable the development of new diagnostic tests and drug treatments for the disease. "We discovered a new pathway that plays a part in schizophrenia," said Prof. Gozes. Brain-cell death also occurs in schizophrenics, so Prof. Gozes and her colleagues set out to see if blocked autophagy could be involved in the progression of that condition as well. They found RNA evidence of decreased levels of the protein beclin 1 in the hippocampus of schizophrenia patients, a brain region central to learning and memory. Beclin 1 is central to initiating autophagy - its deficit suggests that the process is indeed blocked in schizophrenia patients. The researchers say that developing drugs to boost beclin 1 levels and restart autophagy could offer a new way to treat schizophrenia. "It is all about balance," said Prof Gozes. "Paucity in beclin 1 may lead to decreased autophagy and enhanced cell death. Our research suggests that normalizing beclin 1 levels in schizophrenia patients could restore balance and prevent harmful brain-cell death." Next, the researchers looked at protein levels in the blood of schizophrenia patients. They found no difference in beclin 1 levels, suggesting that the deficit is limited to the hippocampus. This said, the researchers also found increased levels of another protein, activity-dependent neuroprotective protein (ADNP), discovered by Prof. Gozes and shown to be essential for brain formation and function, in the patients' white blood cells. Prof. Gozes discovered ADNP in 1999 and carved a protein fragment, NAP, from it. NAP mimics the protein nerve cell protecting properties. In follow-up studies Prof. Gozes helped develop the drug candidate davunetide (NAP). In Phase II clinical trials, davunetide (NAP) improved the ability of schizophrenic patients to cope with daily life. A recent collaborative effort by Prof. Gozes and Dr. Sandra Cardoso and Dr. Raquel Esteves showed that NAP improved autophagy in cultures of brain-like cells. Now Prof. Illana Gozes of Tel Aviv University's Sackler Faculty of Medicine has developed a new peptide in her lab, called NAP or Davunetide, which has the capacity to both protect and restore microtubule function. The peptide is a compound derived from the protein ADNP, which regulates more than 400 genes and is essential for brain formation, memory, and behaviour. Prof. Gozes and her team of researchers, including Dr. Yan Jouroukhin and graduate student Regin Ostritsky of TAU, observed that in animal models with microtubule damage, NAP was able to maintain or revive the transport of proteins and other materials in cells, ameliorating symptoms associated with neurodegeneration. Prof. Gozes is the director of TAU's Adams Super Center for Brain Studies and holds the Lily and Avraham Gildor Chair for the Investigation of Growth Factors. NAP appears to have widespread potential in terms of neuroprotection, says Prof. Gozes, who was recently awarded the Meitner-Humblodt Research Award for her lifelong contribution to the field of brain sciences.


www.inrl.org

Past President: Prof. Illana Gozes, Tel Aviv University


Editorial Board | Journal of Alzheimer's Disease

www.j-alz.com [cached]

Illana Gozes, PhD
Associate Editor Tel Aviv University


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