â€œWe hope that in the future, it will be possible to use our discovery to develop a simple blood test for this serious disease even in its early stages,â€� said TAU lead researcher Prof. Illana Gozes.
"We hope that in the future, it will be possible to use our discovery to develop a simple blood test for this serious disease even in its early stages," said TAU lead researcher Prof. Illana Gozes.
Today, diagnosing Alzheimer's is a long and complicated process, and most doctors use subjective memory tests of cognitive and functional abilities and behavior changes, she
said on Tuesday.
Sometimes, invasive tests of the brain and spinal fluids are conducted, noted Gozes
of the department of human molecular genetics and biochemistry at TAU 's Sackler Faculty of Medicine and of the Sagol School of Neuroscieces
The new discovery, just published in the Journal of Alzheimer's Disease
may lead to a significant breakthrough in diagnosing Alzheimer's, she
This is the protein that accumulates in the brains of Alzheimer's patients, said Gozes
, but sometimes, it is also found in smaller amounts in the brains of healthy people.
"We sought to compare the amount of amyloid in the brain and the expression of ADNP in their blood," she
This was carried out by TAU researchers, who found a connection between the two.
The higher the amount of amyloid in the brain, the lower the amount of RNA genetic material associated with ADNP.
The two experiments on older but healthy people found a link between ADNP levels and its expression in the blood and their cognitive abilities.
Thus, the better their cognitive abilities, the higher the ADNP level in the blood, Gozes
We now intend to expand the experiments on additional populations," Gozes