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This profile was last updated on 5/18/15  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Huei-Sheng Vincent Chen

Wrong Dr. Huei-Sheng Vincent Chen?

Associate Professor, Development,...

Phone: (858) ***-****  
Email: h***@***.org
Sanford-Burnham Medical Research Institute
10901 North Torrey Pines Road
La Jolla , California 92037
United States

Company Description: At Sanford-Burnham, we are dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. With operations...   more
Background

Employment History

Education

  • Ph.D. , Biological Chemistry and Molecular Pharmacology
    Harvard Medical School
  • M.D
  • Ph.D.
  • M.D.
22 Total References
Web References
Huei-Sheng Vincent Chen, ...
sanfordburnham.org, 18 May 2015 [cached]
Huei-Sheng Vincent Chen, Ph.D.
Associate Professor Development, Aging, and Regeneration Program
Dr. Chen investigates the factors controlling development, maturation and function of various ion channels in cardiac and neurological systems to develop pharmacological and therapeutic interventions for cardiac arrhythmia, cardiomyopathy, and neurodegenerative diseases using stem cell-based approaches.
Huei-Sheng Vincent Chen, ...
www.sanfordburnham.org, 3 Sept 2010 [cached]
Huei-Sheng Vincent Chen, B.M., Ph.D.
Assistant Professor Development and Aging
858-646-3183 (phone) hsv_chen@sanfordburnham.org
...
Huei-Sheng Vincent Chen earned his Ph.D. in Biological Chemistry and Molecular Pharmacology at Harvard Medical School in 1993 and his B.M. (M.D. equivalent) at College of Medicine, National Taiwan University. He completed residency training in Internal Medicine at Brigham and Women's Hospital, Harvard Medical School. He then completed his Cardiology and Cardiac Electrophysiology fellowship at the Beth-Israel Deaconess Medical Center, Harvard Medical School. He received postdoctoral training in Dr. Stephen Heinemann's Laboratory at The Salk Institute and cardiac electrophysiology training with Dr. Mark Josephson and Dr. Gregory Feld. Dr. Chen was recruited to Sanford-Burnham Medical Research Institute as assistant professor in 2002.
Selected Publications
Chen, H-S. V., Pellegrini, J. W., Aggarwal, S. K., Lei, S-Z., Warach, S., Jensen, F.E. and Lipton, S. A. Open channel block of N-methyl-D-aspartate (NMDA) responses by memantine: Therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neuroscience 12: 4427-4436, 1992.
Lipton, S. A., Choi, Y-B., Pan, Z-H., Lei, S. Z., Chen, H-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., Stamler, J. S. A redox-based mechanism for neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature (London) 364:626-632, 1993.
Sullivan, J. M., Traynelis, S. F., Chen, H-S. V., Escobar, W., Heinemann, S. F., and Lipton, S. A. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron 13: 929-936, 1994.
Chen, H-S. V. and Lipton, S. A. Mechanism of memantine block of N-Methyl-D-aspartate-activated channel in rat retinal ganglion cells: Uncompetitive antagonism. J. Physiol. (London) 499.1: 27-46, 1997.
Chen, H-S. V., Wang, Y. F., Rayudu, P. V., Edgecomb, P., Neill, J. C., Lipton, S. A., and Jensen, F. E. Neuroprotective concentrations of the NMDA open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or LTP. Neuroscience 86:1121-1132, 1998.
Choi, Y.-B., Tenneti, L., Le , D. A., Ortiz, J., Bai, G., Chen, H.-S. V., and Lipton, S. A.. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nature Neuroscience 3:15-21, 2000.
Choi, Y.-B., Chen, H.-S.
...
Chen, H-S.
Burnham Institute for Medical Research - News Releases - February 16, 2007
www.burnham.org, 16 Feb 2007 [cached]
Vincent Chen, Assistant Professor - Development of Neuro-Coupled Human Embryonic Stem Cell-Derived Cardiac Pacemaker Cells
Faculty A-Z
www.sanfordburnham.org, 19 Nov 2011 [cached]
Vincent Chen, B.M., Ph.D.
...
Dr. Chen investigates the factors controlling development, maturation and function of various ion channels in cardiac and neurological systems, so as to develop pharmacological and therapeutic interventions for cardiac arrhythmia, cardiomyopathy, and neurodegenerative diseases using stem cell-based approaches.
In collaboration with Assistant Professor ...
www.sanfordburnham.org, 23 April 2012 [cached]
In collaboration with Assistant Professor Vincent Chen, Dr. Mercola's group is examining how the stem cells in these cultures are communicating with their mature cardiomyocyte neighbors.
...
Dr. Chen's expertise in measuring electrical activity in cells and the communication between them is allowing the team to characterize the electrical behavior of the differentiated stem cells and compare it to that of normal mature cardiomyocytes.
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