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6154 Nancy Ridge Drive
San Diego, California 92121
Arena embraces the challenge of improving health by seeking to bring innovative medicines targeting G protein-coupled receptors to patients. Arena's focus is discovering, developing and commercializing drugs to address unmet medical needs, and BELVIQÂ® (l ... more
Associate Director, Medicinal Chemistry
AstraZeneca R&D Molndal, Sweden
Head of Medicinal Chemistry
Ferring Research Institute, Southampton, UK
GPCR-Based Drug Discovery - Discovery On Target - Day 1
GPCR-Based Drug Discovery Conference - Day 1 - Discovery On Target
The design and optimization of new prostacyclin receptor agonists with oral activity in rat models of pulmonary arterial hypertension will be described.
As well as in vitro and in vivo potency, special attention was paid to pharmacokinetic parameters eventually resulting in the discovery of the clinical candidate, APD811.
rehabilitation - 5 Continents Coffees
Semple the data from the common Arena Merck research program reinforces the hypothesis that it may be possible for a compound to identify the niacin receptor activated without flushing, thereby the separation of the positive effects on fatty acids from the flushing side effect ed treatment . - This work was not previously reported and within within the past three years, Semple noted. In addition, no other pharmaceutical companies on new compounds for these targets in the open literature are described, high-density lipoprotein patents have appeared. .
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