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Dr. Graeme Semple

Vice President Discovery Chemistry

Arena Pharmaceuticals , Inc.

Direct Phone: (858) ***-**** ext. ****       

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Arena Pharmaceuticals , Inc.

6154 Nancy Ridge Drive

San Diego, California 92121

United States

Company Description

Arena embraces the challenge of improving health by seeking to bring innovative medicines targeting G protein-coupled receptors to patients. Arena's focus is discovering, developing and commercializing drugs to address unmet medical needs, and BELVIQ® (l ... more

Find other employees at this company (262)

Background Information

Employment History

Associate Director, Medicinal Chemistry

AstraZeneca R&D Molndal, Sweden

Head of Medicinal Chemistry

Ferring Research Institute, Southampton, UK

Post Doc

University of Bath

Post Doc

University of Oxford



Web References (24 Total References)

Graeme Semple, Arena ... [cached]

Graeme Semple, Arena Pharmaceuticals, USA

GPCR-Based Drug Discovery - Discovery On Target - Day 1 [cached]

Graeme Semple, Ph.D., Vice President, Discovery Chemistry, Arena Pharmaceuticals

GPCR-Based Drug Discovery Conference - Day 1 - Discovery On Target [cached]

Graeme Semple, Ph.D., Vice President, Discovery Chemistry, Arena Pharmaceuticals, Inc.

The design and optimization of new prostacyclin receptor agonists with oral activity in rat models of pulmonary arterial hypertension will be described. As well as in vitro and in vivo potency, special attention was paid to pharmacokinetic parameters eventually resulting in the discovery of the clinical candidate, APD811.

Graeme Semple, Arena ... [cached]

Graeme Semple, Arena Pharmaceuticals, UK

rehabilitation - 5 Continents Coffees [cached]

Semple the data from the common Arena Merck research program reinforces the hypothesis that it may be possible for a compound to identify the niacin receptor activated without flushing, thereby the separation of the positive effects on fatty acids from the flushing side effect ed treatment . - This work was not previously reported and within within the past three years, Semple noted. In addition, no other pharmaceutical companies on new compounds for these targets in the open literature are described, high-density lipoprotein patents have appeared. .

Graeme Semple, Vice President of Discovery Chemistry at Arena Pharmaceuticals, San Diego, California, describes new insights into the development of drugs that raise HDL via the same mechanism as niacin in a report to the 233rd national meeting presented by the American Chemical Society, held here last week. Read more >

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