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Dr. Graeme Semple

Scientific Founder

Beacon Discovery Inc

HQ Phone: (858) 247-0001

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Beacon Discovery Inc

6118 Nancy Ridge Dr.

San Diego, California 92121

United States

Company Description

Beacon Discovery was founded in 2016 to take advantage of unique advances in the science of G-Protein Coupled Receptors (GPCRs). We are comprised of a team of dedicated scientists who have worked together for the last decade. Our mission is to efficiently ... more

Find other employees at this company (6)

Background Information

Employment History

Post Doc

University of Oxford

Vice President Discovery Chemistry

Arena Pharmaceuticals , Inc.


AstraZeneca PLC

Head of Chemistry

Ferring Research Institute Inc


Post-Doctoral Fellow
University of Bath





University of Warwick , UK

Web References (25 Total References)

Graeme Semple, ... [cached]

Graeme Semple, Ph.D.

Vice President, Chemistry
Graeme Semple has more than 26 years of drug discovery experience in the pharmaceutical industry, both in biotech and big pharma, most recently at Arena Pharmaceuticals where he was VP of Discovery Chemistry and oversaw medicinal chemistry and early development projects. More than a dozen of these projects delivered candidates into preclinical and clinical development in the areas of Metabolism, CNS, Inflammation and Cardiovascular disease. Prior to Arena, he was a Disease Area Chemist at AstraZeneca, Mölndal, Sweden, where he initiated a number of early stage medicinal chemistry projects in the GI area. Prior to AstraZeneca, he was Head of Chemistry at Ferring Research Institute, Southampton, U.K., where he led chemistry groups contributing to multi-national collaborative projects that delivered clinical candidates in the areas of cardiovascular, GI and urology. He is a co-inventor of the GnRH antagonist drug Firmagon ® (Degarelix) which has been approved in 74 countries. He was a post-doctoral fellow at the Universities of Bath and Oxford, UK and has a Ph.D. in Chemistry from the University of Warwick, UK.

Graeme Semple, Arena ... [cached]

Graeme Semple, Arena Pharmaceuticals, USA

GPCR-Based Drug Discovery - Discovery On Target - Day 1 [cached]

Graeme Semple, Ph.D., Vice President, Discovery Chemistry, Arena Pharmaceuticals

GPCR-Based Drug Discovery Conference - Day 1 - Discovery On Target [cached]

Graeme Semple, Ph.D., Vice President, Discovery Chemistry, Arena Pharmaceuticals, Inc.

The design and optimization of new prostacyclin receptor agonists with oral activity in rat models of pulmonary arterial hypertension will be described. As well as in vitro and in vivo potency, special attention was paid to pharmacokinetic parameters eventually resulting in the discovery of the clinical candidate, APD811.

Graeme Semple, Arena ... [cached]

Graeme Semple, Arena Pharmaceuticals, UK

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