Gloria DiLullo, MSN, CRNP, OncoLink Medical Oncology Educational Content Specialist, responds:
In terms of sexual activity, if there is any chance of your wife getting pregnant (i.e. she
has not yet entered menopause), then you must use contraception and avoid pregnancy while on chemotherapy, as birth defects can occur from the chemotherapy.
Some chemotherapy is excreted in a very small amount in semen, especially within 48 hours of treatment.
Even if your wife is past child-bearing age, you should use a condom if you have intercourse within 48 hours after your treatment to avoid exposing her
to any small amounts of chemotherapy in the semen.