In 2011, the Agency for Healthcare Research and Quality awarded the Johns Hopkins Evidence-Based Practice Center a $475,000 project to carry out the research, which was led by Gerald Lazarus, MD, founder of the Johns Hopkins Wound Healing Center and professor of dermatology and medicine at Johns Hopkins Bayview Medical Center; and Jonathan Zenilman, MD, scientific director of the Wound Healing Center and professor of medicine and chief of the Division of Infectious Diseases at Johns Hopkins Bayview.
Results suggested that cadexomer iodine and collagen may also increase healing, says Lazarus
"That doesn't mean that other types of dressings don't work.
It just means that there is no evidence yet on which treatments work the best," says Lazarus
Support stockings, he
adds, must for now remain the standard of care for treating chronic venous ulcers.
says the review also showed evidence is inconclusive about using systemic antibiotics unless there are demonstrated signs of infection.
And it is also inconclusive about such surgical treatments as radiofrequency ablation, endovenous laser treatment and sclerotherapy helped healing, although surgical correction of underlying pathology did decrease recurrence of ulcers.
"There is a critical need for well-designed research studies to compare the current minimally invasive surgical interventions to the gold standard of care, compression therapy," he
says, "The review should serve as a means to bring the wound healing community together to improve the situation.