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Wrong George Dubyak?

Dr. George R. Dubyak

HQ Phone: (301) 634-7060

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Molecular Pharmacology

9650 Rockville Pike

Bethesda, Maryland 20814

United States

Company Description

Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are bro ... more

Find other employees at this company (66)

Background Information

Employment History

Cell Physiologist

Case Western Reserve University

Professor of Physiology and Biophysics

VA Medical Center



Web References (26 Total References)

Mol Pharm Editorial Board [cached]

GEORGE DUBYAK, Case Western Reserve University School of Medicine

George R. Dubyak, Case ... [cached]

George R. Dubyak, Case Western Reserve University, Cleveland, OH

Rammelkamp Center for Education & Research - Seminars [cached]

George Dubyak, Ph.D. Professor, Physiology & Biophysics Case Western Reserve University

Rammelkamp Center for Education & Research - Seminars [cached]

George Dubyak, Ph.D. Professor Department of Physiology and Biophysics Case Western Reserve University

Their findings help explain the mystery ... [cached]

Their findings help explain the mystery of how relatively localized contact between a cell and a pathogen or product of cell damage can lead to widespread inflammation, explained George Dubyak, a cell physiologist at Case Western Reserve University in Cleveland, Ohio, who was not involved in the study. "The inflammasome specks can become carriers for intracellular signaling," he said.

Dubyak suggested that another route would be to block pyroptosis of cells with activated inflammasomes to prevent ASC specks from escaping in the first place. He added that an important next step will be understand how healthy tissues put the brakes on inflammasome-induced inflammation.
"A lot of the inflammasome biology that was not making sense to us is starting to make a lot more sense," he said.

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