(21 Total References)
Speakers' Bureau - Society for Theriogenology
Gary J. Nie, DVM, MS, PhD
Diplomate ACT, ABVP, ACVIM, cVMA
World Wide Veterinary Consultants, LLC
1332 W. Sunshine
Springfield, MO 65807
AAEP Convention 2004: Reducing Drug Costs and Side Effects of Prostaglandins - TheHorse.com
Gary J. Nie, DVM, PhD, consultant for World Wide Veterinary Consultants, LLC in Rochester, Minn., conducted a study while at Auburn University where he compared "micro" doses of both products with standard doses for their ability to affect luteolysis and short-cycle mares.He also evaluated the ability of microdoses to reduce side effects observed with standard doses. Nie
found that a microdose of CLO is equally as effective at short-cycling mares as standard doses of PGF2 or CLO, yet it virtually eliminates unwanted side effects and reduces drug costs by 1,000-2,000%.He
does not recommend a single microdose of PGF2, however, because of a delayed progesterone drop observed in the treated mares.
Prostaglandin's function in this case is to lyse the progesterone-producing corpus luteum left after ovulation, and return the mare to estrus.Thus, a progesterone drop is indicative of prostaglandin efficacy.
In the study, Nie
treated 17 mares (in 57 cycles) intramuscularly with either the standard doses or microdoses of CLO (Nie administered only 5-10% of the standard dose of CLO as the microdose--25 micrograms rather than 250 to 500 micrograms) of PGF2 (0.5 mg instead of 10 mg), or the control (sterile water) on Day 6 after ovulation.Their progesterone levels and ovarian activity were monitored daily. Nie
said, "Their progesterone concentrations were quite interesting.
said the drop in rectal temperature observed probably reflected heat loss through evaporation of sweat. Nie
has used the same microdose of CLO in a 900-pound Arabian mare as he
has used in a 1,600-pound Warmblood mare with much success in both.
American College of Theriogenologists
Dr. Gary Nie President
American College of Theriogenologists
The American College of Theriogenologist would like to welcome Dr. Gary Nie as the New American College of Theriogenologists President for the remainder of 2007 and for 2008.
July 2005, Vol 2, Iss 6
About Dr. Nie
Dr. Gary Nie
is the founder and primary contributor to the Equine Reproduction Newsletter.
hard work and dedication to providing useful information about equine reproduction to individuals throughout industry is truly appreciated by his
For new ERN subscribers, who may not be familiar with Dr. Nie's
background, the following is a mini-bio that will help you get to know him a little better.
Dr. Nie is a veterinarian with more than 17 years experience in clinical practice, teaching and research.
He's board certified with the American College of Theriogenologists, the American Board of Veterinary Practitioners (Equine Specialty) and the American College of Veterinary Internal Medicine.
also possesses two graduate degrees in Theriogenology.
works are widely published, he
speaks regularly to professional and industry groups, and is widely recognized as an expert in equine reproduction.
As a consultant with World Wide Veterinary Consultants, LLC, Dr. Nie provides consulting services and support in equine reproduction to his clientele.
strongly believes success in equine reproduction is the result of a cooperative team effort.
You can learn more about Dr. Nie's background and qualifications, the services he offers and how you can make him a member of your equine reproduction team by visiting the WWVC website.
Dr. Nie's Contributions to the ERN
The ERN is provided FREE of charge to its subscribers through the unselfish efforts and contributions of Dr. Gary Nie
and in cooperation with World Wide Veterinary Consultants, LLC.
willingness to share his
knowledge with anyone interested in equine reproduction is truly laudable.
Every month he
spends considerable time researching and putting together his
articles so you have the information you need to be successful.
If you need the assistance of an equine reproduction specialist don't forget Dr. Nie
and World Wide Veterinary Consultants
also produces more complete and extensive educational materials to help you better meet your goals.