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This profile was last updated on 12/4/15  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Gary D. Lopaschuk

Wrong Dr. Gary D. Lopaschuk?


Phone: (613) ***-****  HQ Phone
Local Address:  Canada
Royal Society of Canada
Walter House 282 Somerset Street West
Ottawa , Ontario K2P 0J6

Company Description: The Royal Society of Canada is a registered charitable organization. Since its founding the Society has sought to maintain a diversity of sources of funding in...   more

Employment History

Board Memberships and Affiliations


  • BSc
  • PhD , Pharmacology and Toxicology
    University of British Columbia
  • Bachelor of Pharmacy degree
    University of British Columbia
123 Total References
Web References
Dr. Gary D. Lopaschuk ..., 4 Dec 2015 [cached]
Dr. Gary D. Lopaschuk Degrees BSc, University of British Columbia, Canada PhD, University of British Columbia, Canada Current position Scientific Director, Mazankowski Alberta Heart Institute, University of Alberta Distinguished University Professor, Departments of Pediatrics and Pharmacology, University of Alberta Alberta Heritage Foundation for Medical Research Scientist Appointments Project Leader, CFI "Cardiovascular Translational Research Centre" Director of Research, Department of Pediatrics, University of Alberta BioAlberta Leadership in Science & Innovation Award Canadian Cardiovascular Society Research Achievement Award Medical Advisory Board, Heart and Stroke Foundation of Alberta, N.W.T. and Nunavut, member Chair, Personal Program Review Task Force, Heart and Stroke Foundation of Canada NIH "Metabolism and Myocardial Ischemia" Study Section, Member Chairman, Scientific Review Committee, Heart and Stroke Foundation of Alberta Editorial Board, Circulation Research Editorial Board, J Clinical Investigation Associate Editor, Americal Journal of Physiology, Heart Associate Editor, Canadian Journal of Physiology and Pharmacology Editorial Board, Cardiovascular Research Editorial Board, Basic Research in Cardiology Scientific Advisory Committee, Women's and Children's Health Research Institute Consulting experience Extensive consulting track record with pharma and named on hundreds of patents. Biography Dr. Gary D. Lopaschuk is a Distinguished University Professor of Pediatrics at the University of Alberta, Edmonton. He is a Cardiovascular Researcher whose research focuses on the regulation of fatty acid oxidation in the heart, and the mechanism by which high rates of fatty acid oxidation contribute to heart disease and heart failure. He is also examining how alterations in fatty acid metabolism contribute to cardiovascular disease in the diabetic. At a molecular level he has characterized a number of key enzymes important in the regulation of cardiac fatty acid oxidation. He is also developing a number of therapeutic strategies that involve optimizing energy metabolism in the heart that can be used to prevent the development of heart disease, and that can also be used to treat heart failure. His research has resulted in the publication of over 330 original research articles, and he has been recognized by awards such as the Canadian Cardiovascular Research Achievement Award and the International Academy of Cardiovascular Sciences Research Achievement Award. Dr. Lopaschuk is an Alberta Innovates Health Solution Scientist, and is a Fellow of the Royal Society of Canada. He serves on a number of journal editorial boards, including Circulation Research, Journal of Clinical Investigation, American Journal of Physiology, Cardiovascular Research, Journal of Molecular and Cellular Cardiology, Canadian Journal of Physiology and Pharmacology, Heart and Metabolism, and Cardiovascular Drugs and Therapy. He is also the President and CEO of a biotechnology company (Metabolic Modulators Research Ltd.), that is developing novel drugs to treat heart disease that optimize energy metabolism in the heart.
Gary Lopaschuk, PhD-People-Cardiovascular Research Centre, 15 Oct 2015 [cached]
Home > People **> Profile of Gary Lopaschuk, PhD
Profile of Gary Lopaschuk, PhD
Gary Lopaschuk
423 Heritage Medical Research Centre
Dr. Gary Lopaschuk (Departments of Pediatrics and Pharmacology) focuses on the regulatory pathways involved in energy metabolism in the heart, particularly the integrated regulation of fatty acid oxidation and carbohydrate metabolism in both the normal heart, the heart of a diabetic, and the reperfused ischemic heart.
Overall, Dr. Lopaschuk believes that optimizing fuel use by the heart has tremendous potential for treating heart disease. His ongoing research studies could help realize this potential.
In fetal life, the heart obtains most of its energy requirements from the metabolism of carbohydrates. However, within days of birth, fatty acid oxidation increases dramatically (over 10 fold) and becomes the major fuel of the heart. Dr. Lopaschuk's team has defined what molecular changes occur in the heart that are responsible for this switch in energy preference.
Dr. Lopaschuk's laboratory and others have shown that decreasing fatty acid use by the heart will increase the use of sugars as a source of energy, which then decreases the likelihood of the diabetic developing heart problems. His team has obtained a better understanding of how fatty acid use by the heart is regulated in the diabetic. His lab has shown that activity of some key enzymes involved in the regulation of fatty acid metabolism is altered. He is presently determining if returning the activity of these enzymes to normal improves heart function in the diabetic.
News Releases - ExpressNews - University of Alberta, 28 Jan 2002 [cached]
"The potential benefits of metabolic modulation are enormous: this new class of drugs tackles the number one cause of death and disability in North America - cardiovascular disease," said Gary Lopaschuk, Director of the UofA's Cardiovascular Research Group and President and CEO of MMRL.
Formed in 1997 with the assistance of the university's Industry Liaison Office and the Faculty of Medicine and Dentistry, and support from the Alberta Heritage Foundation for Medical Research (AHFMR), MMRL has become a world leader in the development of metabolic modulators.
, Dr. Gary Lopaschuk, CEO of MMRL, Director of Research in the Department of Pediatrics for the Faculty of Medicine at the University of Alberta, and the University of Alberta's Director of the Cardiovascular Research Group
Board and Advisories - CDRD, 7 June 2014 [cached]
Dr. Gary Lopaschuk, Departments of Pediatrics and Pharmacology, University of Alberta
An Outstanding Research Initiative | 1 | Pagetitle, 25 Dec 2014 [cached]
On December 16, Kedryn gave her Public Seminar in front of a large audience (I counted 98) and defended her thesis with an unconditional pass . We welcomed my long-time colleague, Dr . Gary Lopaschuk, Director of the Mazankowski Heart Institute and Distinguished University Professor at the University of Alberta, as Kedryn's external examiner . On December 21 Mer, who had joined the lab in the summer, passed her candidacy exam with flying colors . I would like to thank all the examiners for their time and diligence . You have certainly succeeded in your determination to raise the bar for our students and for the lab . Likewise, I thank the CRB Program for providing an intellectual home for our students . The next to defend his thesis will be Shiraj (MD/PhD student) whose exam is on February 14, 2012 . Shiraj has already interviewed at several clinical investigator programs for his residency training .
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