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This profile was last updated on 10/15/15  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Gary D. Lopaschuk

Wrong Dr. Gary D. Lopaschuk?

Employment History

Board Memberships and Affiliations


  • BSc
  • PhD , Pharmacology and Toxicology
    University of British Columbia
  • Bachelor of Pharmacy degree
    University of British Columbia
125 Total References
Web References
Gary Lopaschuk, PhD-People-Cardiovascular Research Centre, 15 Oct 2015 [cached]
Home > People **> Profile of Gary Lopaschuk, PhD
Profile of Gary Lopaschuk, PhD
Gary Lopaschuk
423 Heritage Medical Research Centre
Dr. Gary Lopaschuk (Departments of Pediatrics and Pharmacology) focuses on the regulatory pathways involved in energy metabolism in the heart, particularly the integrated regulation of fatty acid oxidation and carbohydrate metabolism in both the normal heart, the heart of a diabetic, and the reperfused ischemic heart.
Overall, Dr. Lopaschuk believes that optimizing fuel use by the heart has tremendous potential for treating heart disease. His ongoing research studies could help realize this potential.
In fetal life, the heart obtains most of its energy requirements from the metabolism of carbohydrates. However, within days of birth, fatty acid oxidation increases dramatically (over 10 fold) and becomes the major fuel of the heart. Dr. Lopaschuk's team has defined what molecular changes occur in the heart that are responsible for this switch in energy preference.
Dr. Lopaschuk's laboratory and others have shown that decreasing fatty acid use by the heart will increase the use of sugars as a source of energy, which then decreases the likelihood of the diabetic developing heart problems. His team has obtained a better understanding of how fatty acid use by the heart is regulated in the diabetic. His lab has shown that activity of some key enzymes involved in the regulation of fatty acid metabolism is altered. He is presently determining if returning the activity of these enzymes to normal improves heart function in the diabetic.
News Releases - ExpressNews - University of Alberta, 28 Jan 2002 [cached]
"The potential benefits of metabolic modulation are enormous: this new class of drugs tackles the number one cause of death and disability in North America - cardiovascular disease," said Gary Lopaschuk, Director of the UofA's Cardiovascular Research Group and President and CEO of MMRL.
Formed in 1997 with the assistance of the university's Industry Liaison Office and the Faculty of Medicine and Dentistry, and support from the Alberta Heritage Foundation for Medical Research (AHFMR), MMRL has become a world leader in the development of metabolic modulators.
, Dr. Gary Lopaschuk, CEO of MMRL, Director of Research in the Department of Pediatrics for the Faculty of Medicine at the University of Alberta, and the University of Alberta's Director of the Cardiovascular Research Group
Board and Advisories - CDRD, 7 June 2014 [cached]
Dr. Gary Lopaschuk, Departments of Pediatrics and Pharmacology, University of Alberta
Gary Lopaschuk | Alberta Heart, 5 Feb 2015 [cached]
Gary Lopaschuk
Scientific Director, Mazankowski Alberta Heart Institute Professor, Department of Pediatrics Adjunct Professor, Department of Pharmacology University of Alberta
Dr. Gary Lopaschuk focuses on the regulatory pathways involved in energy metabolism in the heart, particularly the integrated regulation of fatty acid oxidation and carbohydrate metabolism in both the normal heart, the heart of a diabetic, and the reperfused ischemic heart.
To understand Dr. Lopaschuk's work, one needs to know that the heart requires fuel from a balance of fat and carbohydrate sugars in order to maintain normal pump function. In many forms of heart disease, the heart shifts to using fat as its primary energy source, which is harder on the heart.
In 2010, Dr. Lopaschuk was awarded the title of Distinguished University Professor. He demonstrates his commitment to learning through teaching and mentoring, saying: "In the classroom and in my laboratory, everyone is aware they're going to be asked to participate and come up with ideas. It's important that students are thinking while they're learning, not just memorizing the material…and they're not going to learn unless they find it interesting."
Click here for a clip on why Gary chose science.
MMRL - Management Team, 8 Mar 2015 [cached]
Gary Lopaschuk
Gary Lopaschuk, B.Sc. (Pharm), MSc, PhD is the President and CEO of MMRL. He is the majority and controlling shareholder of MMRL. He is responsible for the overall scientific direction of the company.
Other People with the name "Lopaschuk":
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