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2013-09-18T00:00:00.000Z

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Wrong C. Starmer?

Dr. C. Frank Starmer Jr.

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Email: f***@***.sg

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National University of Singapore

21 Lower Kent Ridge Road

Singapore, Central Singapore 119077

Singapore

Company Description

A leading global university centred in Asia, the National University of Singapore (NUS) is Singapore's flagship university, which offers a global approach to education and research, with a focus on Asian perspectives and expertise. NUS has 16 faculties ... more

Find other employees at this company (18,482)

Background Information

Employment History

MEDNIVA PTE. LTD

Scholarpedia

Professor of Bioinformatics and Biostatistics

Duke University

Associate Provost for Information Technology

Medical University of South Carolina

Visiting Professor

Institute of Theoretical and Experimental Biophysics

Fulbright Visiting Professor

University of Patras

Visiting Professor

Indian Institute of Technology Madras

Visiting Professor

All Union Center for Cardiology, Moscow

Affiliations

Academic Advisor, Associate Dean
Learning Technologies

Education

Ph.D.

Web References (45 Total References)


Team | Medniva

www.medniva.com [cached]

Dr. Frank Starmer

Academic Advisor Associate Dean, Learning Technologies, Duke-NUS Graduate Medical School, Singapore (2006-2015)


Physiome Sciences, Inc.

www.physiome.com [cached]

C. Frank Starmer, Ph.D.Dr. Starmer is the Associate Provost for Information Technology at the Medical University of South Carolina.In 1992, he initiated the "laboratory without walls" that linked investigators at universities and research institutes using the internet.


Watch the unbuilding (demolition) of the Pearman and Grace Bridges (old Cooper River Bridges)

www.oldcooperriverbridge.org [cached]

Gary Eaton, Frank Starmer and Sparky Witte

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You cannot imagine how much new life and energy these folks have brought into the lives of Frank and Ellen Starmer in Charleston.
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Frank Starmer, Medical University of South Carolina.


Initiation of excitation waves - Scholarpedia

www.scholarpedia.org [cached]

C. Frank Starmer (2007), Scholarpedia, 2(2):1848.

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Frank Starmer
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Dr. C. Frank Starmer, Duke - NUS Graduate Medical School Singapore
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Bountis, T., Bezerianos, T. and Starmer, C.F. Wavefront formation in an excitable medium by perturbation of solitary pulse solutions. Progress in Theoretical Physics, 139:12-33 (supplement), 2000 Ostrovskii, L.A. and Yakhno, V.G. Formation of pulses in an excitable medium. Biofizika 20:489-493, 1975 Starobin, J., Zilberter, Y.I. and Starmer, C.F. Vulnerability in one-dimensional excitable media. Physica D. 70:321-341, 1994
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C. Frank Starmer (2007) Vulnerability of cardiac dynamics. Scholarpedia, 2(11):1847.
External Links C. Frank Starmer's website
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"Initiation of excitation waves" by C. Frank Starmer is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License . Permissions beyond the scope of this license are described in the Terms of Use


Vulnerability of cardiac dynamics - Scholarpedia

www.scholarpedia.org [cached]

C. Frank Starmer (2007), Scholarpedia, 2(11):1847.

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Frank Starmer
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Dr. C. Frank Starmer, Duke - NUS Graduate Medical School Singapore
Figure 1: Each propagating excitation wave is trailed by a region of recovering cells.
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For example, use-dependent drugs that bind to cardiac sodium channels reduce the density of sodium channels and retard the recovery of excitability (Starmer, C.F., Lastra, A.A., Nesterenko, V.V. and Grant, A.O. 1991; Starmer, C.F., Lancaster, A.R., Lastra, A.A. and Grant. A.O., 1992)resulting in slowed conduction. Similarly sodium channel mutations that alter cardiac excitability have an enhanced proarrhythmic potential (Grant, A.O., et. al, 2002; Starmer, C.F., Colatsky, T.J. and Grant, A.O., 2003a). Clinical trials of antiarrhythmic drugs have uniformly revealed that use-dependent drugs that reduce excitability by binding to cardiac sodium channels display proarrhythmic behavior, i.e. there is an increase in the rate of sudden cardiac death associated with the use of drugs classified as antiarrhythmic (see Cardiac Arrhythmia Suppression Trial (CAST) Investigators, 1989; The Cardiac Arrhythmia Suppression Trial-II Investigators, 1992). The mechanism of failure of these clinical trials is consistent with the concept of the vulnerable region described above. Specifically any drug that reduces the excitability will also slow propagation of a wave thereby enlarging the vulnerable region and the probability that spontaneous oscillation of cells within the vulnerable region will trigger a reentrant arrhythmia (Wiener, N. and Rosenblueth, A, 1946; Starmer et. al, 1991, Starmer et. al, 1993, Starobin, J., Zilberter, Y.I. and Starmer, C.F., 1994).
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Whitcomb, D.C., Gilliam, F.R., Starmer, C.F. and Grant, A.O. Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine. Journal of Clinical Investigation 1989; 84:1629-1636. Starmer, C.F., Lastra, A.A., Nesterenko, V.V. and Grant, A.O. A proarrhythmic response to sodium channel blockade: Theoretical model and numerical experiments. Circulation 1991; 84:1364-1377. Starmer, C.F., Lancaster, A.R., Lastra, A.A. and Grant. A.O. Cardiac instability amplified by use-dependent Na channel blockade. American Journal of Physiology 1992; 262:H1305-H1310. Nesterenko, V.V., Lastra, A.A., Rosenshtraukh, L.V. and Starmer, C.F.
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Gomez-Gesteira, M., Fernandez-Garcia, G., Munuzuri, A.P., Perez-Munuzuri, V., Krinsky, V.I., Starmer, C.F. and Perez-Villar, V. Vulnerability in an excitable Belousov-Zhabotinsky medium: from 1D to 2D. Physica D 1994; 76:359-368. Starobin, J., Zilberter, Y.I. and Starmer, C.F. Vulnerability in one-dimensional excitable media. Physica D. 1994; 70:321-341.
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Starmer, C.F.,Romashko, D.,Reddy, R.S., Zilberter, Y.I., Starobin, J., Grant, A.O. and Krinsky, V.I. Proarrhythmic Response to Potassium Channel Blockade: Numerical Studies of Polymorphic Tachyarrhythmias. Circulation 1995; 92:595-605.
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Grant, A.O., Carboni, M.P., Neplioueva, V., Starmer, C.F., Memmi, M., Napolitano, C. and Priori, S. Long QT, Brugada and conduction system disease linked to a single Na channel mutation. J. Clin Invest. 2002; 110:1201-1209. Starmer, C.F., Colatsky, T.J. and Grant, A.O. What happens when cardiac Na channels lose their function? 1: Numerical studies of the vulnerable period in tissue expressing mutant channels. Cardiovascular Research 2003a; 57:82-91. Starmer, C.F., Grant, A.O. and Colatsky, T.J.
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C. Frank Starmer (2007) Initiation of excitation waves. Scholarpedia, 2(2):1848.
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"Vulnerability of cardiac dynamics" by C. Frank Starmer is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License . Permissions beyond the scope of this license are described in the Terms of Use

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