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"Hearts from diabetic db/db mice, a model of type 2 diabetes, exhibit left ventricular failure and altered metabolism of exogenous substrates," explained Ellen Aasum and colleagues at the University of Tromso in Norway.The investigators treated 8-week-old db/db mice with 25 to 38 mg/kg per day of the PPAR-alpha ligand, BM 17.0744, for 4 to 6 weeks, and measured the effect of treatment on cardiac function and metabolism. The elevated concentrations of glucose (34.0 mM), fatty acids (2.0 mM), and triglycerides (0.9 mM) found at the beginning of treatment dropped to normal levels after BM 17.0744 therapy (10.8, 1.1, and 0.6 mM, respectively).Mice that received BM 17.0744 also had significantly lower levels of plasma insulin than did control mice. Fatty acid oxidation dropped by 50% in mice that had undergone long-term BM 17.0744 treatment, resulting in a 1.7-fold increase in glycolysis and 2.3-fold increase in glucose oxidation.
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