"With this analysis, we sought to determine what treatment women selected when diagnosed with DCIS, and whether there was any impact in mortality with the different treatments," said senior author E. Shelley Hwang, MD, chief of breast surgery at the Duke Cancer Institute.
"This is an important women's health issue, and we still do not have enough data around what the best treatment is," Hwang
"Studies like ours should be viewed as a call for well-designed clinical trials that could provide more information to better guide both doctors and patients."
and colleagues used data from the Surveillance, Epidemiology, and End Results (SEER) program in the United States to analyze more than 121,000 cases between 1991 and 2010 in which women were diagnosed with DCIS.
"One of the things we wanted to examine was what happened to these women after they were diagnosed with DCIS," Hwang
"Overall, 9.2% of all deaths were due to breast cancer.
However, the predominant cause of death was not breast cancer, but cardiovascular disease, which accounted for 33% of all deaths."
said the exception was among women younger than age 50 with DCIS, where one-third of deaths resulted from breast cancer, highlighting the importance of aggressive treatment for those patients.
"What our study shows is that we urgently need clinical trials to know whether we are doing the right thing for this group of patients," Hwang