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Wrong Douglas Ruden?

Dr. Douglas M. Ruden

Director of Epigenomics

Wayne State University

HQ Phone: (313) 577-8845

Email: d***@***.edu

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Wayne State University

5057 Woodward Avenue Suite 3101

Detroit, Michigan 48202

United States

Company Description

Wayne State University is one of the nation's pre-eminent public research universities in an urban setting. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, t ... more

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Background Information

Employment History

Field Chief Editor for Toxicogenomics

Frontiers in genetics


Board of Trustees Member
Gordon Research Conferences incorporated



Institute of Environmental Health Sciences

Web References (20 Total References)

Gordon Research Conferences - 2009 Program (Epigenetics) [cached]

Discussion Leader: Doug Ruden (Wayne State University)

Doug Ruden: Synthesis & Discussion - Lamarckian genetics via environmental influences and prions?

Gordon Research Conferences - 2008 Program (Environmental Endocrine Disruptors) [cached]

Douglas M. Ruden (Wayne State University)

Flint’s kids “will have to be ... [cached]

Flint’s kids “will have to be followed throughout their whole life, and maybe into the next generation or two,� says Douglas Ruden, a neural toxicologist at Wayne State University in Detroit. A few months of drinking clean water will help bring the kids’ lead levels back down, he says. “But the damage is done.� And it’s permanent.

IMAGE: This is Dr. ... [cached]

IMAGE: This is Dr. Douglas Ruden, professor in the Department of Obstetrics & Gynecology and the Institute of Environmental Health Sciences, director of epigenomics, and program leader in the Center for... view more

In the recent Wayne State study led by Douglas Ruden, Ph.D., professor in the Department of Obstetrics & Gynecology and the Institute of Environmental Health Sciences, director of epigenomics, and program leader in the Center for Urban Responses to Environmental Stressors, he and his research team revealed that lead exposure can cause specific changes in DNA methylation, which can be detected in dried blood spots beyond one generation. The neonatal blood spots from both the mothers and children in this study were obtained from the Michigan Neonatal Biobank, a unique resource that has most of the neonatal dried blood spots from children born in Michigan since 1984.
According to Ruden, epigenetic effects of environmental exposures beyond one generation have not yet been demonstrated in humans prior to this study. He and his team tested the hypothesis that human fetal germ cell exposure to environmental toxins causes epigenetic changes in the newborn blood from a grandchild of an exposed pregnant woman.
"Our results suggest that lead exposure during pregnancy affects the DNA methylation status of the fetal germ cells, which leads to altered DNA methylation in grandchildren's neonatal dried blood spots," said Ruden. "This is the first demonstration that an environmental exposure in pregnant mothers can have an epigenetic effect on the DNA methylation pattern in the grandchildren."
The research team stated that this novel, two-generational study design might be able to identify the genes that may serve as possible candidate biomarkers for future transgenerational risk assessment studies.
"Our pilot study provides indirect evidence that lead exposure in women during childbirth can affect the locus-specific DNA methylation status of grandchildren," said Ruden. "However, the altered DNA methylation profiles of the grandchildren's blood are apparently normalized during postnatal development. Also, fetal germline exposure to lead apparently has different epigenetic consequences than acute childhood exposure."
This research was supported by the National Institute of Environmental Health Sciences of the National Institutes of Health (R01 ES012933 and R21 ES021893) to Dr. Ruden, the WSU-NIEHS Center (P30 ES020957), and a Michigan Bloodspot Environmental Epidemiology Project (BLEEP) pilot grant from the Michigan University Research Corridor to Dr. Ruden.
Douglas Ruden, Wayne State University - Office of the Vice President for Research
Douglas Ruden, Wayne State University - Office of the Vice President for Research (IMAGE) Multimedia

Wayne State University ... [cached]

Wayne State University researcher Douglas Ruden, PhD, calls the toxin-obesity link "a well-substantiated theory in the scientific community.

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