Donald Henderson, Ph.D. is a Professor in the Department of Communicative Disorders and Sciences at the University at Buffalo.
As a highly respected auditory neuro scientist, Dr. Henderson has been chipping
away at the noise-induced hearing loss issue for over 36 years.
Initial studies in Dr. Henderson's
UB lab attempted to provide support to the concept that NAC
would exhibit its protective properties in the cochlea.
was placed on theround window of the cochleas of chinchillas that acted as subjectsfor a noise exposure experiment.
administration and defined noise treatments, electrophysiological measures and histological studies of the animals' cochleas were completed.
The results were as Dr. Henderson's
The NAC-treated cochleas sustained less of a sensory cell insult from the noise exposures than the cochleas of the animals that did not receive the compound.
According to Dr. Henderson, "the first controlled study, supervised by Army Colonel Richard Kopke, MD, is about to get underway to determine if the effects of NAC are generalizable to humans with regard to hearing conservation".
The hope is that Dr. Henderson's
findings in the chinchilla model will replicate in the basic trainees receiving NAC supplementation.
"Noise exposure has been shown to not only affect the sensory cells of the cochlea, but also the junction between the cells, specifically at the Deiter's cups in which they rest", accord ing to Dr. Henderson
Hangauer's compound is a small molecule that prevents a certain kind of apoptosis and therefore we believe we can reduce or prevent dam-age we see occurring at the cell junctions".
and his Center for Hearing
and Deafness colleagues put a small amount of Dr. Hangauer's compound (CH-65) on the round window of chinchillas and then exposed the animals to noise.