The findings have implications for management of chronic diseases, such as urinary tract infections.
The discovery by a team of scientists working in the laboratory of David Low, professor of biology at the University of California, Santa Barbara, is reported in the August 19 issue of the journal Science.
The findings indicate that Escherichia coli, one culprit in urinary tract infections, contains genes that when turned on block the growth of other E. coli bacteria that they touch.
The finding was a complete surprise to the scientists, said Low.
The discovery may eventually lead to new antimicrobial agents to halt bacterial growth which would be an entirely new system to shut bacteria down, according to the scientists.
"This has potential implications for new antibiotics," said Low
After working for two years, the team identified two genes required for this "stop on contact" phenomenon.
"We don't know if these 'stopped' cells are dead or alive," said Low
These genes are present in E. coli
, including uropathogenic E. coli that cause urinary tract infections, and similar genes may be present in other pathogens such as the plague bacillus, Yersinia pestis." Low
said that one possible interpretation is that bacteria use this system to eliminate competition in the environments they grow in. "Another possibility is that the bacteria use the CDI system to shut themselves off inside a host, going into a dormant state where they may go undetected by the immune system," he
Thousands of women in this country have chronic urinary tract infections, noted the scientists.
The disease seems to go away for awhile, then something triggers recurrence of the disease.
Work by Scott Hultrgen at Washington University
has indicated that E. coli cells may hide in the walls of the bladder and urinary tract in a dormant state, explained Low
"This research is in its infancy, but opens the door for exploration of the roles of contact-dependent growth inhibition in urinary tract infections and possibly other diseases," said Low
"Aoki has discovered an entirely new phenomenon," explained Low, who has studied E. coli
for over 20 years.