(52 Total References)
David Low (University of ...
www.gordonconferences.org, 22 May 2014 [cached]
David Low (University of California, Santa Barbara)
"Mechanisms of Self/Non-Self Recognition and Generation of Toxin Diversity in CDI and Rhs Contact-Dependent Growth Inhibition Systems"
RxPG News : Microbiology
www.rxpgnews.com, 23 Dec 2004 [cached]
The findings have implications for management of chronic diseases, such as urinary tract infections. The discovery by a team of scientists working in the laboratory of David Low, professor of biology at the University of California, Santa Barbara, is reported in the August 19 issue of the journal Science.
The findings indicate that Escherichia coli, one culprit in urinary tract infections, contains genes that when turned on block the growth of other E. coli bacteria that they touch.
The finding was a complete surprise to the scientists, said Low. The discovery may eventually lead to new antimicrobial agents to halt bacterial growth which would be an entirely new system to shut bacteria down, according to the scientists.
"This has potential implications for new antibiotics," said Low.
After working for two years, the team identified two genes required for this "stop on contact" phenomenon. "We don't know if these 'stopped' cells are dead or alive," said Low
These genes are present in E. coli
, including uropathogenic E. coli that cause urinary tract infections, and similar genes may be present in other pathogens such as the plague bacillus, Yersinia pestis." Low
said that one possible interpretation is that bacteria use this system to eliminate competition in the environments they grow in. "Another possibility is that the bacteria use the CDI system to shut themselves off inside a host, going into a dormant state where they may go undetected by the immune system," he
said. Thousands of women in this country have chronic urinary tract infections, noted the scientists.
The disease seems to go away for awhile, then something triggers recurrence of the disease. Work by Scott Hultrgen at Washington University
has indicated that E. coli cells may hide in the walls of the bladder and urinary tract in a dormant state, explained Low
"This research is in its infancy, but opens the door for exploration of the roles of contact-dependent growth inhibition in urinary tract infections and possibly other diseases," said Low
. "Aoki has discovered an entirely new phenomenon," explained Low, who has studied E. coli
for over 20 years.
Dozens of steelhead anglers were fishing ...
www.spokane.net, 4 Mar 2009 [cached]
Dozens of steelhead anglers were fishing the Wynoochee River in Grays Harbor over the Feb. 28 weekend, but success was marginal, said David Low, WDFW fish biologist.
The same was true for the Satsop, where anglers came up with virtually nothing.
"We had an early run of hatchery fish, but overall the seasonâ€™s not been very productive," Low said.
Record low flows this winter on the Olympic Peninsula combined with possibly lower run returns for the year may be contributing to the problem, he said.
flows may be problematic for bank anglers, he
Remedyne Management Team
www.remedyne.com, 26 Feb 2003 [cached]
David Low, Ph.D.Chief Scientific Officer and Director Dr. Low is currently a professor in the department of Molecular, Cellular and Developmental Biology at the University of California, Santa Barbara.Previously, he served as a professor in the department of Pathology at the University of Utah and also served on editorial boards of Applied and Environmental Biology and Microbiology.Dr. Low
has been honored with an NIH Career Development Award and the LaSalle Memorial Scholarship in Microbiology.He
has contributed to over 53 publications in biochemistry, immunology and molecular biology and is a co-holder of the patent (pending) for Remedyne's
DNA Adenine Methylase Technology.Dr. Low completed his Ph.D. at the University of California, Irvine and received his postdoctoral fellow at Stanford University.
Low and clear water have made ...
www.tacomanwtf.org, 3 Sept 2008 [cached]
Low and clear water have made it tough for anglers fishing the Quillayute system on the northern Olympic Peninsula, said David Low, WDFW fish biologist.