Dr David Hughes, BMedSci, MB ChB, PhD, FRCPath
Consultant Histopathologist and Cancer Lead Clinician/Associate Medical Director for Cancer Services, Sheffield Teaching Hospitals NHS Foundation Trust; Honorary Senior Lecturer, University of Sheffield.
Dr Hughes obtained a BMedSci at the University of Sheffield in 1985 and went on to complete a PhD in 1988 and to graduate in Medicine in 1989 at the same University.
He then worked as a Clinical Lecturer in Pathology at the University of Edinburgh between 1990 and 1995.
During this period he
also undertook a sabbatical (1994-95) as Visiting Assistant Professor at the University of Texas Health Science centre, San Antonio.
Dr Hughes then worked as a Clinical Lecturer in Pathology at the University of Sheffield between 1995 and 1998.
Since then, David has worked as an NHS Consultant Histopathologist at Chesterfield Royal Hospital (1998-2003), the Royal Orthopaedic Hospital, Birmingham (2003-5) and Sheffield Teaching Hospitals from 2005 onwards.
David's initial research was the investigation of the role of cytokines in bone metabolism and through his
developed an interest in understanding the mechanism of action of bisphosphonates.
This interest was carried forward during his
sabbatical in San Antonio, establishing the pro-apoptotic effect of bisphosphonates on osteoclasts and during his
clinical lectureship in Sheffield he
contributed to the work of the team of Dr (now Professor) Mike Rogers in demonstrating the role of the mevalonate pathway in bisphosphonate action.
More recently, David
has worked collaboratively, using his
skills in tissue interpretation to contribute to a variety of projects such as describing the phenotype of IL-1 receptor antagonist knockout mice and tissue engineering using conditionally-immortalised chondrocyte progenitors.
David currently collaborates with Professor Peter Croucher's group and contributes histology support to the Sheffield Bone Biomedical Research Unit.