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This profile was last updated on 9/16/15  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. David J. Glass

Wrong Dr. David J. Glass?

Executive Director, Muscle Diseas...

Phone: (617) ***-****  
Email: d***@***.com
Novartis Institutes for BioMedical Research Inc
100 Technology Square
Cambridge , Massachusetts 02139
United States

Company Description: The Novartis Institutes for BioMedical Research, based in Cambridge, Mass., will focus on disease areas with significant new opportunities, according to the...   more

Employment History

Board Memberships and Affiliations


  • MD
    New York Medical College
  • undergraduate degree
    Columbia University
  • M.D.
    New York Medical College
60 Total References
Web References
Urban Debate Leagues > Who We Are > Our Board, 16 Sept 2015 [cached]
David Glass Global Head, Muscle Diseases Novartis Institutes for Biomedical Research
SMA Foundation | Scientific Advisory Board, 14 June 2012 [cached]
David J. Glass, MD
Dr. David J. Glass has been the Global Head of Muscle Diseases research at Novartis Institutes for Biomedical Research since 2005. A native of New York, Dr. Glass received his undergraduate degree from Columbia University and his MD from New York Medical College. After postdoctoral work at Columbia, he worked at Regeneron Pharmaceuticals for 14 years before establishing the Muscle Diseases group at Novartis.
Dr. Glass's research has led to several key scientific findings in the area of skeletal muscle atrophy and hypertrophy. He is the co-author of more than 60 peer-reviewed articles on cell signaling mechanisms in neuromuscular disease, obesity, and cancer.
Dr. Glass is an elected member of the American Society for Biochemistry and Molecular Biology and the American Society for Clinical Investigation. He is also a Visiting Scientist at Harvard Medical School, where he teaches a course on experimental design. His book, Experimental Design for the Practicing Biologist, was well-reviewed and, in addition, he co-authored a paper that appeared in the "Leading Edge" section of the journal Cell on the philosophy of science, advocating the use of questions as opposed to hypotheses in framing experimental projects.
For GDF11, "You could imagine that ... [cached]
For GDF11, "You could imagine that when it came out last year that it helped muscle, it was quite a surprise," says David Glass, executive director of the muscle diseases group at the Novartis Institutes for Biomedical Research in Cambridge, Massachusetts. "Did we miss something?"
Glass and his colleagues set out to determine why GDF11 had this apparent effect. First, they tested the reagents that Wagers' group had used to measure GDF11 levels, and found that these chemicals could not distinguish between myostatin and GDF11. When the Novartis team used a more specific reagent to measure GDF11 levels in the blood of both rats and humans, they found that GDF11 levels actually increased with age - just as levels of myostatin do. That contradicts what Wagers' group had found.
Glass's team next used a combination of chemicals to injure a mouse's skeletal muscles, and then regularly injected the animal with three times as much GDF11 as Wagers and her team had used.
Rather than regenerating the muscle, Glass found, GDF11 seemed to make the damage worse by inhibiting the muscles' ability to repair themselves. He and his colleagues report their results on 19 May in Cell Metabolism4.
Glass says that although his group's results do not explain why parabiosis works, they could help to explain the mechanism behind bimagrumab, an experimental Novartis treatment muscle weakness and wasting. The drug, which is currently in clinical trials, blocks myostatin - and perhaps GDF11 as well.
Meticulous methods
Thomas Rando, a stem-cell biologist at Stanford University in California, praises the attention to detail in the methods used by Glass and his team.
The FSH Society Board of Directors, 25 Dec 2014 [cached]
David J. Glass, M.D.
David J. Glass, M.D. Dr. Glass is Global Head, Muscle Diseases for Novartis Institutes for Biomedical Research, Cambridge, Massachusetts. Prior to joining Novartis, he was Vice President for Muscle Diseases at Regeneron Pharmaceuticals, where he worked for 14 years. He holds an M.D. from New York Medical College and conducted postdoctoral work at Columbia University. He is the co-author of more than 50 peer-reviewed research articles on cell signaling mechanisms in neuromuscular disease, obesity, and cancer.
Michelle and her husband, David, have two daughters.
Bioresearch Online News for bioresearch and life sciences professionals, 2 Nov 2001 [cached]
David J. Glass , M.D. , Vice President of the Muscle Program and New Technology at Regeneron , and a senior author on the manuscripts , noted , Defining the gene products which cause the muscle growth which follows exercise or the muscle atrophy following various disease processes , and then showing that genetic manipulation of these can overcome the muscle loss seen in disease models , nicely demonstrates the power of our Functionomics ( ) capabilities.The next step is to target these molecules so as to discover highly specific therapeutic drug candidates that promote muscle growth and maintenance..
Sue Bodine , Ph.D. , Director of the Muscle Program and a primary author of the papers , added , Since muscle loss is such an important medical problem , not only in disease settings but even during normal aging , we're excited that we have the opportunity to explore the therapeutic implications of our findings..
The work described above was performed as part of a research and development collaboration with The Procter & Gamble Company.Regeneron and P&G jointly will commercialize any products derived from the work and share profits equally.
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