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2015-10-18T00:00:00.000Z

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Wrong David Glass?

Dr. David Glass J.

Head Muscoskeletal

Novartis Institutes for BioMedical Research Inc

HQ Phone: (617) 871-8000

Email: d***@***.com

Novartis Institutes for BioMedical Research Inc

250 Massachusetts Avenue

Cambridge, Massachusetts 02139

United States

Company Description

The Novartis Institutes for BioMedical Research, based in Cambridge, Mass., will focus on disease areas with significant new opportunities, according to the company, and will take advantage of synergies among research efforts globally. The company expec ... more

Find other employees at this company (1,140)

Background Information

Employment History

Co-Chairs
Novartis AG

Vice President
Regeneron Pharmaceuticals , Inc.

Visiting Scientist
Harvard Medical School

Director of Debate
Edgemont High School

Affiliations

co-Editor-in-Chief, Founder
Skeletal Muscle, Biomednet central

Governing Board Members Member
National Association for Urban Debate Leagues

Elected Member
American Society for Clinical Investigation

Elected Member
American Society for Biochemistry and Molecular Biology

Scientific Advisory Board Member
Spinal Muscular Atrophy Foundation

Individual Lifetime Member
National Debate Coaches Association

Education

M.D.

Novartis Institutes for Biomedical Research

MD

New York Medical College

undergraduate degree

Columbia University

Web References (79 Total References)


Biomarkers & Medical Diagnostics | Leaders in Pharmaceutical Business Intelligence

pharmaceuticalintelligence.com, $reference.date [cached]

According to Jocelyn Kaiser, writing at the Science web site, David Glass, who works at the Novartis Institutes for Biomedical Research in Cambridge, Massachusetts, and his colleagues have made use of an antibody that specifically binds to GDF11 to detect the protein and measure its concentration in the blood and tissues.


Urban Debate Leagues > Who We Are > Our Board

urbandebate.org, $reference.date [cached]

David Glass Global Head, Muscle Diseases Novartis Institutes for Biomedical Research


In the Pipeline:

pipeline.corante.com, $reference.date [cached]

For GDF11, "You could imagine that when it came out last year that it helped muscle, it was quite a surprise," says David Glass, executive director of the muscle diseases group at the Novartis Institutes for Biomedical Research in Cambridge, Massachusetts. "Did we miss something?"

Now in Cell Metabolism, Glass and co-workers are reporting that GDF11 does not, in fact, have the effects ascribed to it.


The collaboration came about when ...

www.iss-casis.org, $reference.date [cached]

The collaboration came about when CASIS encouraged David Glass, an executive director in the musculoskeletal disease research area at NIBR, to submit a proposal. Glass has co-authored about one hundred articles on the molecular mechanisms of muscle growth and muscle atrophy.

...
Glass discovered this protein and its role before arriving at Novartis.


360 degrees of health science and

healthyhealth360.blogspot.ca, $reference.date [cached]

For GDF11, "You could imagine that when it came out last year that it helped muscle, it was quite a surprise," says David Glass, executive director of the muscle diseases group at the Novartis Institutes for Biomedical Research in Cambridge, Massachusetts. "Did we miss something?"

Glass and his colleagues set out to determine why GDF11 had this apparent effect.
...
Glass's team next used a combination of chemicals to injure a mouse's skeletal muscles, and then regularly injected the animal with three times as much GDF11 as Wagers and her team had used.
...
Rather than regenerating the muscle, Glass found, GDF11 seemed to make the damage worse by inhibiting the muscles' ability to repair themselves.
He and his colleagues report their results on 19 May in Cell Metabolism.
Glass says that although his group's results do not explain why parabiosis works, they could help to explain the mechanism behind bimagrumab, an experimental Novartis treatment for muscle weakness and wasting.
The drug, which is currently in clinical trials, blocks myostatin-and perhaps GDF11 as well.
Meticulous methods
Thomas Rando, a stem-cell biologist at Stanford University in California, praises the attention to detail in the methods used by Glass and his team.

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