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2015-09-30T00:00:00.000Z

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Wrong Chi-Ming Hai?

Dr. Chi-Ming Hai

Professor of Medical Science

Brown University

HQ Phone: (401) 863-1000

Brown University

10 Prospect Street

Providence, Rhode Island 02912

United States

Company Description

At Brown, the ACRIN Biostatistics and Data Management Center provides leadership and sup-port in the design, implementation, and analysis of network studies that examine the role of imaging in the diagnosis and disease management of cancer. Center faculty ... more

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Background Information

Education

Ph.D.

Web References (9 Total References)


News / Sylvan Wellness

www.sylvanwellness.com, $reference.date [cached]

During the American Society for Cell Biology Annual Meeting in New Orleans, Chi-Ming Hai, professor of medical science at Brown University, described a connection he found between nicotine and atherosclerosis. In lab experiments, Hai observed that nicotine promotes the formation of invasive structures in vascular smooth muscle cells that damage them in a way that can potentially promote plaque formation in atherosclerosis.

"Altogether the data from the studies of rat and primary human vascular smooth muscle cells suggest that nicotine enhances vascular smooth muscle cell invasion by activating synergistic mechanisms between the nicotinic acetylcholine receptor and protein kinase C signaling."
Hai subjected rat and primary human vascular smooth muscle cells to prolonged (six hours) nicotine treatment.


These findings suggest that e-cigarettes, ...

www.eurekalert.org, $reference.date [cached]

These findings suggest that e-cigarettes, the battery-powered devices that deliver nicotine in steam without the carcinogenic agents of tobacco smoke, may not significantly reduce smokers' risk for heart disease, said Chi-Ming Hai, Ph.D., of Brown University.

E-cigarettes have put nicotine back in the news and into the hands of a growing number of U.S. smokers who now "vape," that is, inhale a steam of nicotine, polyethylene glucose (PEG) and flavoring generated by cigarette-shaped vaporizers.
Alhough e-cigarettes are being promoted as "safe" nicotine delivery systems, the safety of nicotine has been disputed, partly because the mechanism by which it acts on the circulatory system has not been well understood.
Dr. Hai's research on human and rat vascular smooth muscle cells provides evidence of a link between nicotine and atherosclerosis.
In Dr. Hai's experiments, nicotine appeared to drive the formation of a kind of cellular drill called podosome rosettes, which are members of the invadosome family, consisting of invadopodia, podosomes and podosome rosettes. These specialized cell surface assemblies degrade and penetrate the tissue during cell invasion. Invasion of vascular smooth muscle cells from the middle layer of the arterial wall (media) to the inner layer of the arterial wall (intima) contributes substantially to plaque formation in atherosclerosis.
Dr. Hai subjected rat and primary human vascular smooth muscle cells to prolonged (six hours) nicotine treatment, enabling the cells to form podosome rosettes in response to Protein Kinase C (PKC) activation, which controls protein phosphorylation in signal transduction cascades.
...
According to Dr. Hai, a potential clinical implication of these findings is that replacing cigarette smoking by nicotine administration may not bring much benefit to lowering the risk of developing atherosclerosis. Still, Dr. Hai said that he believes that understanding the synergistic mechanisms between nicotinic acetylcholine receptor and PKC in vascular smooth muscle invasion may lead to new therapeutics for minimizing the damaging effects of nicotine on the vascular system.
...
Chi-Ming Hai, Ph.D. Brown University


The lead researcher Chi-Ming ...

www.doctortipster.com, $reference.date [cached]

The lead researcher Chi-Ming Hai, professor of medical science in the Department of Molecular Pharmacology, Physiology, and Biotechnology at Brown University, notes that those who want to quit smoking using nicotine replacement therapy may need to reconsider their treatment option.


Chronic Diseases

www.keepitsacred.org, $reference.date [cached]

These findings suggest that e-cigarettes, the battery-powered devices that deliver nicotine in steam without the carcinogenic agents of tobacco smoke, may not significantly reduce smokers' risk for heart disease, said Chi-Ming Hai, Ph.D., of Brown University.

...
Dr. Hai's research on human and rat vascular smooth muscle cells provides evidence of a link between nicotine and atherosclerosis.
In Dr. Hai's experiments, nicotine appeared to drive the formation of a kind of cellular drill called podosome rosettes, which are members of the invadosome family, consisting of invadopodia, podosomes and podosome rosettes. These specialized cell surface assemblies degrade and penetrate the tissue during cell invasion. Invasion of vascular smooth muscle cells from the middle layer of the arterial wall (media) to the inner layer of the arterial wall (intima) contributes substantially to plaque formation in atherosclerosis.
Dr. Hai subjected rat and primary human vascular smooth muscle cells to prolonged (six hours) nicotine treatment, enabling the cells to form podosome rosettes in response to Protein Kinase C (PKC) activation, which controls protein phosphorylation in signal transduction cascades.
...
According to Dr. Hai, a potential clinical implication of these findings is that replacing cigarette smoking by nicotine administration may not bring much benefit to lowering the risk of developing atherosclerosis. Still, Dr. Hai said that he believes that understanding the synergistic mechanisms between nicotinic acetylcholine receptor and PKC in vascular smooth muscle invasion may lead to new therapeutics for minimizing the damaging effects of nicotine on the vascular system.
...
Chi-Ming Hai, Ph.D. Brown University


These findings suggest that e-cigarettes, ...

www.keepitsacred.org, $reference.date [cached]

These findings suggest that e-cigarettes, the battery-powered devices that deliver nicotine in steam without the carcinogenic agents of tobacco smoke, may not significantly reduce smokers' risk for heart disease, said Chi-Ming Hai, Ph.D., of Brown University.

...
Dr. Hai's research on human and rat vascular smooth muscle cells provides evidence of a link between nicotine and atherosclerosis.
In Dr. Hai's experiments, nicotine appeared to drive the formation of a kind of cellular drill called podosome rosettes, which are members of the invadosome family, consisting of invadopodia, podosomes and podosome rosettes. These specialized cell surface assemblies degrade and penetrate the tissue during cell invasion. Invasion of vascular smooth muscle cells from the middle layer of the arterial wall (media) to the inner layer of the arterial wall (intima) contributes substantially to plaque formation in atherosclerosis.
Dr. Hai subjected rat and primary human vascular smooth muscle cells to prolonged (six hours) nicotine treatment, enabling the cells to form podosome rosettes in response to Protein Kinase C (PKC) activation, which controls protein phosphorylation in signal transduction cascades.
...
According to Dr. Hai, a potential clinical implication of these findings is that replacing cigarette smoking by nicotine administration may not bring much benefit to lowering the risk of developing atherosclerosis. Still, Dr. Hai said that he believes that understanding the synergistic mechanisms between nicotinic acetylcholine receptor and PKC in vascular smooth muscle invasion may lead to new therapeutics for minimizing the damaging effects of nicotine on the vascular system.
...
Chi-Ming Hai, Ph.D. Brown University

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