Some 350 different enzymes rely on magnesium, notes cardiovascular biologist Burton M. Altura of the State University of New York Health Science Center at Brooklyn.
That's more uses than the body makes of any other metal, he
Because some studies had identified an apparent magnesium deficiency in the brains of persons suffering from migraines,both during headaches and between attacks,Altura's
group investigated whether rapid infusions of large amounts of the mineral might ameliorate pain.
Subsequent studies of additional migraine patients have confirmed a common pattern, Altura
Diet also fails to predict who will tend to have low ionized magnesium concentrations in blood and tissues, Altura
has found.In a study 4 years ago, he
colleagues recruited 18 healthy young men to take different magnesium supplements for 6 days at a time.Although the volunteers had started the trial with normal total-magnesium concentrations,suggesting their diet had contained the RDA of this mineral,a number of the men still had below normal concentrations of the mineral's ionized form.However, once these men were placed on diets containing four to five times the RDA of the mineral, the proportion of ionized magnesium in their blood climbed into the healthy range,despite no change in total magnesium concentrations.
grainWhat all this suggests, Altura
says, is that whether someone is deficient in the biologically active form of the mineral may not be detectable through measures of total magnesium.Indeed, his
data on cardiac cells indicate that if the concentrations of ionized magnesium falls 25 to 40 percent below normal,irrespective of the total amount of magnesium present,magnesium-dependent enzymes no longer function properly.
...Altura, B.T., ... and B.M. Altura.
...Burton M. AlturaBox 31State University of New York Health Science Center450 Clarkson AvenueBrooklyn, NY 11203