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Wrong Bryce Kerlin?

Bryce A. Kerlin

Program Director, The Joan Fellowship In Pediatric Hemostasis-Thrombosis

Nationwide Children's Hospital

HQ Phone:  (614) 722-2000

Direct Phone: (614) ***-****direct phone

Email: b***@***.org

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I agree to the Terms of Service and Privacy Policy. I understand that I will receive a subscription to ZoomInfo Community Edition at no charge in exchange for downloading and installing the ZoomInfo Contact Contributor utility which, among other features, involves sharing my business contacts as well as headers and signature blocks from emails that I receive.

Nationwide Children's Hospital

700 Children's Drive

Columbus, Ohio,43205

United States

Company Description

Named to the Top 10 Honor Roll on U.S. News & World Report's 2016-17 list of "America's Best Children's Hospitals," Nationwide Children's Hospital is America's largest not-for-profit freestanding pediatric healthcare system providing wellness, preventive, diag...more

Background Information

Employment History

Assistant Scoutmaster

Boy Scouts of America


Scoutmaster, Troop 843, Lewis Center, OH

Boy Scouts of America


Director of the Hemophilia and Bleeding Disorder Program

Columbus Children's Hospital


Associate Hematologist and Oncologist

Rady Children's Hospital


Affiliations

National Hemophilia Foundation

Trustee


Hemedicus Inc

Committee Co-Chair


Education

MD


Web References(23 Total References)


Hematology, Oncology & BMT Team :: Nationwide Children's Hospital

www.nationwidechildrens.org [cached]

Bryce A. Kerlin, MD
Bryce A. Kerlin, MD Hematology & Oncology Hematology & Oncology 700 Children's Dr Columbus, OH 43205 (614) 722-3550 Email Me


Factor V Leiden - PediaCast 175PediaCast

www.pediacast.org [cached]

And to help me do that in the studio today, I'm joined by Dr. Bryce Kerlin.
He's a hematologist at Nationwide Children's, so he'll be here in just a moment. So I am joined in the studio today by Dr. Bryce Kerlin. Dr. Kerlin is an Associate Professor of Pediatrics at the Ohio State University, College of Medicine, and he's the Director of the Hemostasis and Thrombosis Center at Nationwide Children's. 0:01:58 As a physician with the Division of Hematology and Oncology, Dr. Kerlin takes care of children with bleeding and clotting problems and he is a principal investigator for several studies looking at hemophilia and other bleeding disorders. So welcome to PediaCast, Dr. Kerlin. Dr. Bryce Kerlin: Thanks, Mike. Dr. Bryce Kerlin: Correct. Dr. Bryce Kerlin: I did hear about them recently. Dr. Bryce Kerlin: I'll not comment. Dr. Bryce Kerlin: I don't think so. Dr. Bryce Kerlin: Practiced for a couple of years in San Diego - Dr. Bryce Kerlin: - at Rady Children's Hospital and then - Dr. Bryce Kerlin: Yeah. Right. Dr. Bryce Kerlin: Oh, well, here of course. Dr. Bryce Kerlin: Actually, I would prefer to be on a lake in the wilderness of Ontario fishing. Dr. Bryce Kerlin: Yes. Dr. Bryce Kerlin: Summertime. Dr. Bryce Kerlin: That's where I learned to sail. Dr. Bryce Kerlin: Yeah. Dr. Bryce Kerlin: - that I sail on our own creek reservoir, which is a lot of fun actually. Dr. Bryce Kerlin: Maybe I'll remedy that for you. Dr. Bryce Kerlin: I like to go way northwest in Ontario and go canoeing on some of the smaller lakes in the back country and fish for walleye in Northern Pike and muskie. Dr. Bryce Kerlin: That's what I do, so. Dr. Bryce Kerlin: Oh, yeah. Dr. Bryce Kerlin: I'm very outdoor-sy. Dr. Bryce Kerlin: It's been a lot of time way far away from anywhere with no salt hammers. Dr. Bryce Kerlin: No, that's my pop off of... Dr. Bryce Kerlin: Yes, we could. Before we answer it, Dr. Kerlin, if you could just sort of define for our listeners what exactly is Factor V Leiden? Dr. Bryce Kerlin: OK. Dr. Bryce Kerlin: But when you cut your finger in the kitchen or you're otherwise injured, you want your blood to very quickly turn into a solid but only at that site where your injury is because if it continues uncontrolled to turn into a solid, you end up with concrete in your blood vessels and your heart cannot pump the solid. Dr. Bryce Kerlin: And then at the end of that, so you want it controlled, turn it into a solid, and then after the injury heals, you want to turn it back into a liquid. Dr. Bryce Kerlin: I'm not that old. Dr. Bryce Kerlin: Well, that's a really interesting question because it turns out that in addition to being discovered fairly recently, so we don't know as much about it as we could because we haven't had much time to learn, is that it looks like - that it's a fairly new mutation in the human population. Dr. Bryce Kerlin: Which is - that's new for a mutation in the DNA, in the human chromosome. Dr. Bryce Kerlin: In the human genome, that's the word I was looking for. Dr. Bryce Kerlin: Right. Dr. Bryce Kerlin: Right. We're talking about an autosomal dominant mutation or co-dominant mutation. Dr. Bryce Kerlin: Correct, but we need to put that into perspective, OK? Dr. Bryce Kerlin: That's right. Dr. Bryce Kerlin: Right. Dr. Bryce Kerlin: Right. Dr. Bryce Kerlin: Correct. Dr. Bryce Kerlin: Actually, we see that quite not infrequently. Dr. Bryce Kerlin: Right. The same thing with the leg. Dr. Bryce Kerlin: We didn't see that in younger children and then again in adolescents. Dr. Bryce Kerlin: They think of it as a clot and an artery that obstructs blood flow to the brain, and so you get like a wedge shaped dying areas sort of like a heart attack. Dr. Bryce Kerlin: Right. Dr. Bryce Kerlin: With Factor V Leiden? Dr. Bryce Kerlin: There are a lot of - I think the jury is still out on whether Factor V Leiden really increases your risk for heart disease or not. Dr. Bryce Kerlin: Actually, there's a whole - Dr. Bryce Kerlin: As we said, clotting is complex, so there's a whole host of things that we think about. Dr. Bryce Kerlin: Right. Dr. Bryce Kerlin: Well, actually, that's - whether or not there's Factor V Leiden is a pretty straightforward question. Dr. Bryce Kerlin: It's a really easy, but what caused the clot in the first place is a little bit more complex of a question. Dr. Bryce Kerlin: There are different kinds of tests and you're alluding to that. Dr. Mike Patrick: Yes. If you feel like it. Bryce Kerlin: There's an activated protein resistance assay, which was the original assay that they used to discover the problem back in the '90s, but there are a lot of false positives with that assay. So most tertiary care centers have moved towards the direct DNA testing. Dr. Bryce Kerlin: Yes. Dr. Bryce Kerlin: Right. Dr. Bryce Kerlin: These patients are usually closely monitored with frequent blood test among their level of anti-coagulation and there are other drugs besides Coumadin that we use to thin people's blood. Dr. Bryce Kerlin: Well, that's the major complication of blood thinner medication. Dr. Bryce Kerlin: Coumadin, these other ones is bleeding and actually, that was my one comment to the writer is it sounds like she has what we call a provoked thrombosis. Dr. Bryce Kerlin: Or maybe more behind that recommendation for life-long therapy. But from the information she provided, she may not really need that. Dr. Bryce Kerlin: Right. Dr. Bryce Kerlin: Right. Dr. Bryce Kerlin: The answer is maybe. Dr. Bryce Kerlin: But usually not. Dr. Bryce Kerlin: So like we talked about, if you are a healthy child, your risk for clotting is very, very low. Dr. Bryce Kerlin: Correct. Dr. Bryce Kerlin: So their premiums skyrocketed, right? Dr. Bryce Kerlin: So there is a real risk of being identified with having one of these mutations. Dr. Bryce Kerlin: Correct. Dr. Bryce Kerlin: There's a very low number of people affected and when you do the math, the risk is still relatively low. So that - Dr. Bryce Kerlin: - the risk of gene therapy are high enough that I don't think anybody has moved in that direction. Dr. Bryce Kerlin: Absolutely. Dr. Bryce Kerlin: Oh, that has to be Monopoly. Dr. Bryce Kerlin: Yes. Dr. Bryce Kerlin: And there is a kids version of that game; Monopoly Jr. Dr. Bryce Kerlin: I used to - my kids even though they were probably preschool age, we even had a - we said not screen time but there's a computer version of the game. Dr. Bryce Kerlin: My kids enjoy it, so. Dr. Bryce Kerlin: Straightforward, you know, with the little top hat guy. Dr. Bryce Kerlin: Yeah. Dr. Bryce Kerlin: Thanks, Mike. This entry was posted in PediaCast and tagged 22q Center, Bryce A. Kerlin, Center for Clinical and Translational Research, factor v leiden, Hematology, Hematology/Oncology & BMT, Hemostasis and Thrombosis Team, Hospital-Based Research Faculty, Kerlin, Oncology and BMT Fellowship, Pediatric Hemostasis-Thrombosis Fellowship, Pediatrics by Dr. Mike.


www.nationwidechildrens.org

Bryce Kerlin, MD, Receives 2015 CSL Behring Professor Heimburger Award for Investigators
Bryce Kerlin, MD, a principal investigator in the Center for Clinical and Translational Science in The Research Institute and a member of the Division of Hematology/Oncology/Blood and Marrow Transplantation (BMT) at Nationwide Children's Hospital, received the CSL Behring-Professor Heimburger Award in Germany in April 2015.


www.columbusmonthly.com

Bryce A. Kerlin
Nationwide Children's Hospital, Columbus 614-722-6425


Hematology, Oncology & BMT Team :: Nationwide Children's Hospital

www.nationwidechildrens.org [cached]

Bryce A. Kerlin, MD
Bryce A. Kerlin, MD Hematology & Oncology Hematology & Oncology 700 Children's Dr Columbus, OH 43205 (614) 722-3564


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