Brad Zerler, VP of research at CollaGenex, agreed that care should be taken when directly targeting MMPs.
play an important temporal role in wound healing and tissue remodeling," he
"Consequently, there are times when inhibition may be appropriate; but there are times when the enzymes are required and, for those reasons, inhibition would be inappropriate.
Therefore, inhibition of MMPs post-trauma may be quite tricky in regard to timing and needed tissue repair and remodeling."
said doxycycline is less potent than other MMPIs, which he
said could account for the lower incidence of side effects.
"Most in the field think of MMP inhibition in terms of treating chronic conditions, and perhaps that is why their development has been somewhat disappointing," he
proposed that treatment of acute, rather than chronic, pain "may just be the niche for this class of compounds."
added, the Nature Medicine paper "suggests that inhibition of downstream mediators such as IL-1 or perhaps p38 may be more appropriate targets for neuropathic pain."