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This profile was last updated on 3/2/15  and contains information from public web pages and contributions from the ZoomInfo community.

Dr. Angela M. DeMichele

Wrong Dr. Angela M. DeMichele?

Associate Professor of Medicine a...

University of Pennsylvania
3400 Chestnut St
Philadelphia , Pennsylvania 19104
United States

Company Description: The University of Pennsylvania, the country's first university, is an Ivy League institution with a distinctive past. Its four undergraduate schools and 12 graduate...   more

Employment History

Board Memberships and Affiliations


  • MD
  • MSCE
  • B.S. , Biochemistry
    Brown University
  • Masters Degree , Clinical Epidemiology
    University of Pennsylvania
  • M.D.
  • M.S.C.E.
138 Total References
Web References
Expedition Inspiration - Board of Directors, 21 Feb 2015 [cached]
Angela DeMichele, MD, MSCE Angela DeMichele, MD, MSCE, has been our Expedition Inspiration Medical Advisory Committee chair since 2009 and became involved with Expedition Inspiration in 2003.
Dr. DeMichele is an Associate Professor of Medicine and Epidemiology at the University of Pennsylvania and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics. She co-leads the Breast Cancer Research Program of the Abramson Cancer Center and directs the Doris Duke Clinical Research Fellowship Program at the University of Pennsylvania.
Dr. DeMichele earned a B.S. in Biochemistry from Brown University, an M.D. from Washington University School of Medicine (as a Four Schools Physician/Scientist Scholar) and a Masters Degree in Clinical Epidemiology from the University of Pennsylvania. She received her clinical training in Internal Medicine and Hematology/Oncology at the University of Pennsylvania, and joined the faculty in 2000 as a breast cancer oncologist and molecular epidemiologist whose research focuses on identifying markers of outcome, response to therapy and development of targeted therapeutics.
She is currently the PI of numerous clinical trials and epidemiologic studies, including Chair of Trial Operations for the I-SPY2 Trial, a multicenter clinical trial in which targeted therapeutics are tested in the context of molecular and MRI imaging response profiles in patients receiving neoadjuvant therapy for locally-advanced breast cancer, and her work has been funded through the NCI and other charitable foundations.
In addition, she directs Penn's Breast Cancer Survivorship Program, a multidisciplinary clinical research program at the Abramson Cancer Center, where she and her colleagues are performing studies of bone loss, ovarian dysfunction, hot flashes, lymphedema, depression/distress and physical activity in breast cancer survivors.
She is a past recipient of a Young Investigator Award from the American Society of Clinical Oncology, a Clinical Research Training Grant from the American Cancer Society and a Patient-Oriented Career Development Award from the NIH. Dr. DeMichele has served on the American Board of Internal Medicine Oncology Subspecialty Board, the Editorial Board of the Journal of Clinical Oncology and is currently Chair of the Medical Advisory Board of the Expedition Inspiration Fund for Breast Cancer Research. + Expand
Dr. Koop - Existing Drugs May Protect Against Certain Cancers, 14 May 2005 [cached]
The apparent protective effect of raloxifene was most pronounced during the first three years of use, said lead investigator Dr. Angela DeMichele, an assistant professor of medicine at the Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania.
SOURCES: May 14, 2005, press conference with David Price, M.D., director, urologic oncology and clinical research, Regional Urology LLC, Shreveport, La.; Vikas Khurana, M.D., assistant professor, medicine, Louisiana State University Health Sciences Center, Shreveport; Angela DeMichele, M.D., assistant professor, medicine, Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia; May 14, 2005, presentations, American Society of Clinical Oncology, Orlando
Leadership and Administration | Abramson Cancer Center of the University of Pennsylvania, 27 Sept 2014 [cached]
Angela DeMichele, MD, MSCE Breast Cancer Research Program
DeMichele, Angela - Living Beyond Breast Cancer, 4 Dec 2011 [cached]
Angela DeMichele, MD, MSCE
Dr. DeMichele is an associate professor of medicine and epidemiology at the University of Pennsylvania focusing on breast cancer oncology and molecular epidemiology. Through her research, she seeks to identify markers of outcome and response to therapy, as well as develop targeted therapeutics.
Dr. DeMichele is a senior scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania, as well as the co-director of the breast cancer program at the Abramson Cancer Center. She is a member of LBBC's Medical Advisory Board and frequently speaks for us and reviews our publications.
Genetic Profiling in Early-Stage Breast Cancer 1: Neo-Adjuvant Chemotherapy for Operable Breast Cancer | ProvaEducation, 12 Oct 2014 [cached]
Angela DeMichele, MD, MSCE Associate Professor of Medicine and Epidemiology University of Pennsylvania
Angela DeMichele, MD, MSCE Upon completing her MD at Washington University in 1991, Dr. DeMichele returned to Penn to complete an internship in obstetrics and gynecology as well as her residency. After her residency, she spent a year as a visiting clinical fellow at the Istituto di Ematologia Seragnoli, Universita degli Studi di Bologna in Bologna, Italy. Dr. DeMichele pursued her fellowship training in Hematology-Oncology at Penn from 1995-1998. From 1996-2001, Dr. DeMichele worked on completing an MSCE degree and in 1999 was appointed Assistant Professor of Medicine in the Department of Medicine and in the Department of Biostatistics and Clinical Epidemiology in the University of Pennsylvania SOM. She is currently the course director for a graduate-level course (EP815, Clinical Trials and Translational Research) in the CCEB, a thesis advisor, a research mentor for the Hematology/Oncology fellowship program, a mentor for the Department of Medicine Scholarly Pursuit Rotation and a mentor for the Undergraduate Honors Thesis Program. Last year, she received the Alavi Award for Excellence in Cancer Research at the Abramson Cancer Center. Dr. DeMichele was drawn to a career in oncology by the potential to powerfully impact the lives of patients and their families. To illustrate, she recounted a case of a young patient that she cared for during her second month of internship. The young patient was a male who was about her age whose wife was expecting their first child. The patient was diagnosed with acute promyelocytic leukemia and at that time, in 1991, there was no cure. Consequently, the clinical team asked the young patient what his goals were and how they could help him reach them. The patient stated that he just wanted enough time to see his wife deliver their child and to hold his child before he died. By giving the patient blood products they were able to wheel him down from his hospital room to his wife's delivery room and he was able to achieve his dream of holding his infant before he passed away. This concept of setting goals and helping patients reach them is a significant part of Dr. DeMichele's clinical work. She has to give bad news a lot. This is one of the occupational hazards associated with working in oncology. Communicating this bad news to patients and assisting them in setting realistic goals is very important to Dr. DeMichele. She was fortunate to have learned from her mentors during her fellowship how to deal with this aspect of the job. Dr. DeMichele's face instantly lights up when asked about how she deals with the stresses of working in her field. She doesn't hesitate for a second before stating how her family helps her to keep balanced and to see what is important in life. Dr. DeMichele is married to fellow CCEBer Robert Gross and together they have two sons, Elliot (11) and Jesse (8).
In addition to her clinical work, Dr. DeMichele is currently the PI of numerous clinical trials and epidemiologic studies. She is a co-PI of the national I-SPY trial, a multicenter study examining molecular and novel MRI imaging response profiles of patients receiving neoadjuvant therapy for locally-advanced breast cancer that is co-sponsored by the American College of Radiology Imaging Network, The Cancer and Leukemia Group B, and Specialized Programs of Research Excellence mechanisms. Work on I-SPY is currently in its final stages and investigators are using data in designing I-SPY II. Dr. DeMichele also collaborates with fellow CCEB faculty on various clinical research trials. Working with Drs.
Along with Dr. Jun Mao, Assistant Professor of Family Medicine and Community Health, Dr. DeMichele is investigating links between use of aromatase inhibitors, cytokine receptors and arthritic syndrome to look for markers associated with this clinical syndrome and resistance to endocrine therapy.
With Dr. Irene Su, a junior faculty member in reproductive endocrinology here at UPHS, Dr. DeMichele is investigating markers of early menopause and bone loss among premenopausal patients receiving adjuvant chemotherapy.
Dr. DeMichele is also working with Dr. Mark Rosen, Assistant Professor of Radiology, using very novel imaging, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), to examine basal phenotypes of breast cancer in women who are "triple negative" (lacking estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2).
In discussing breast cancer, Dr. DeMichele indicates that for all of the attention and press that it receives, breast cancer remains underappreciated. Although she admits there have been GREAT strides, she is just as quick to point out that there are still WAY too many women (especially young women under 40 years old) who are being diagnosed with Stage 4 breast cancer who are living for a few years but still dying too young. She suggests that there is a need for better predictors so people don't relapse and a need for better screening for younger women.
Angela M. DeMichele, MD, MSCE Reviewer Research: Genetech, Inc., Wyeth Pharmaceuticals
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