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2016-10-24T00:00:00.000Z

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Wrong Angela DeMichele?

Dr. Angela M. DeMichele

Direct Phone: (215) ***-****       

Email: a***@***.edu

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University of Pennsylvania

3400 Chestnut St

Philadelphia, Pennsylvania 19104

United States

Company Description

The University of Pennsylvania School of Nursing is one of the world's leading schools of nursing, is consistently ranked as one of the top graduate nursing schools in the United States, and is among the nation's top recipients of nursing research funding ... more

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Background Information

Employment History

//www.standup2cancer.org/

Assistant Professor, Medicine and Epidemiology

Cancer

Position In Breast Cancer Program

Abramson Cancer Center

Affiliations

Chair of the Medical Advisory Board
Expedition Inspiration

Member of Medical Advisory Board
LBBC

Board Member
Mac Publishing LLC

Member, Editorial Board
Journal of Clinical Oncology

Chair of the Medical Advisory Board
EI

Board Member
American Board of Internal Medicine

Member of Medical Advisory Board
Living Beyond Breast Cancer

Education

B.S.

Biochemistry

Brown University

M.S.C.E.

MD

MD

University of Pennsylvania

MD

University of Pennsylvania , Philadelphia

MD

Washington University

MSCE

MSCE degree

University of Pennsylvania SOM

Masters Degree

Clinical Epidemiology

University of Pennsylvania

Web References (192 Total References)


Angela DeMichele, ...

www.targetedonc.com [cached]

Angela DeMichele, MD

...
Angela DeMichele, MD
The combination of T-DM1 (ado-trastuzumab emtansine; Kadcyla) and pertuzumab was superior to the combination of paclitaxel and trastuzumab as neoadjuvant treatment for women with HER2-positive breast cancer, according to an analysis the adaptively randomized I-SPY 2 Trial.
The goal of the I-SPY 2 trial was to identify drugs and combinations of drugs to further explore in phase III trials. A drug or combination "graduates" by reaching a threshold predictive probability of success in a subsequent phase III trial. Based on the findings from the study, the T-DM1 combination should now advance into a phase III study, said Angela M. DeMichele, MD, at the 2016 AACR Annual Meeting.
The toxicity profiles favored the T-DM1/pertuzumab combination versus paclitaxel/trastuzumab, with hypertension, neuropathy, and alopecia occurring much less frequently in patients assigned to T-DM1/pertuzumab. "I would argue that these are side effects of treatment that really matter to women, that can really affect their day-to-day function," said DeMichele, professor of medicine and epidemiology, University of Pennsylvania, Philadelphia.
...
"That led to a probability that T-DM1/pertuzumab was superior to [paclitaxel/trastuzumab] of 99.5%, and our probability that it would be successful in a subsequent phase III trial of 94%," said DeMichele.
...
As expected, elevations of alanine aminotransferase and aspartate aminotransferase levels occurred in patients randomized to T-DM1/pertuzumab "but was low grade, and not clinically signi cant," said DeMichele.
"There are numerous phase III trials that are going on now to help establish the role of T-DM1 with or without pertuzumab in the neoadjuvant setting, and we anxiously await those results," she said.


Faculty | TAT Congress

tatcongress.org [cached]

Angela DeMichele, University of Pennsylvania, Philadelphia, PA


Expedition Inspiration - Board of Directors

www.expeditioninspiration.org [cached]

Angela DeMichele, MD, MSCE Angela DeMichele, MD, MSCE, has been our Expedition Inspiration Medical Advisory Committee chair since 2009 and became involved with Expedition Inspiration in 2003.

Dr. DeMichele is an Associate Professor of Medicine and Epidemiology at the University of Pennsylvania and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics. She co-leads the Breast Cancer Research Program of the Abramson Cancer Center and directs the Doris Duke Clinical Research Fellowship Program at the University of Pennsylvania.
Dr. DeMichele earned a B.S. in Biochemistry from Brown University, an M.D. from Washington University School of Medicine (as a Four Schools Physician/Scientist Scholar) and a Masters Degree in Clinical Epidemiology from the University of Pennsylvania. She received her clinical training in Internal Medicine and Hematology/Oncology at the University of Pennsylvania, and joined the faculty in 2000 as a breast cancer oncologist and molecular epidemiologist whose research focuses on identifying markers of outcome, response to therapy and development of targeted therapeutics.
She is currently the PI of numerous clinical trials and epidemiologic studies, including Chair of Trial Operations for the I-SPY2 Trial, a multicenter clinical trial in which targeted therapeutics are tested in the context of molecular and MRI imaging response profiles in patients receiving neoadjuvant therapy for locally-advanced breast cancer, and her work has been funded through the NCI and other charitable foundations.
In addition, she directs Penn's Breast Cancer Survivorship Program, a multidisciplinary clinical research program at the Abramson Cancer Center, where she and her colleagues are performing studies of bone loss, ovarian dysfunction, hot flashes, lymphedema, depression/distress and physical activity in breast cancer survivors.
She is a past recipient of a Young Investigator Award from the American Society of Clinical Oncology, a Clinical Research Training Grant from the American Cancer Society and a Patient-Oriented Career Development Award from the NIH. Dr. DeMichele has served on the American Board of Internal Medicine Oncology Subspecialty Board, the Editorial Board of the Journal of Clinical Oncology and is currently Chair of the Medical Advisory Board of the Expedition Inspiration Fund for Breast Cancer Research. + Expand


Expedition Inspiration - Honorary Board

www.expeditioninspiration.org [cached]

Angela DeMichele, MD, MSCE Angela DeMichele, MD, MSCE, has been our Expedition Inspiration Medical Advisory Committee chair since 2009 and became involved with Expedition Inspiration in 2003.

Dr. DeMichele is an Associate Professor of Medicine and Epidemiology at the University of Pennsylvania and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics. She co-leads the Breast Cancer Research Program of the Abramson Cancer Center and directs the Doris Duke Clinical Research Fellowship Program at the University of Pennsylvania.
Dr. DeMichele earned a B.S. in Biochemistry from Brown University, an M.D. from Washington University School of Medicine (as a Four Schools Physician/Scientist Scholar) and a Masters Degree in Clinical Epidemiology from the University of Pennsylvania. She received her clinical training in Internal Medicine and Hematology/Oncology at the University of Pennsylvania, and joined the faculty in 2000 as a breast cancer oncologist and molecular epidemiologist whose research focuses on identifying markers of outcome, response to therapy and development of targeted therapeutics.
She is currently the PI of numerous clinical trials and epidemiologic studies, including Chair of Trial Operations for the I-SPY2 Trial, a multicenter clinical trial in which targeted therapeutics are tested in the context of molecular and MRI imaging response profiles in patients receiving neoadjuvant therapy for locally-advanced breast cancer, and her work has been funded through the NCI and other charitable foundations.
In addition, she directs Penn's Breast Cancer Survivorship Program, a multidisciplinary clinical research program at the Abramson Cancer Center, where she and her colleagues are performing studies of bone loss, ovarian dysfunction, hot flashes, lymphedema, depression/distress and physical activity in breast cancer survivors.
She is a past recipient of a Young Investigator Award from the American Society of Clinical Oncology, a Clinical Research Training Grant from the American Cancer Society and a Patient-Oriented Career Development Award from the NIH. Dr. DeMichele has served on the American Board of Internal Medicine Oncology Subspecialty Board, the Editorial Board of the Journal of Clinical Oncology and is currently Chair of the Medical Advisory Board of the Expedition Inspiration Fund for Breast Cancer Research. + Expand


Expedition Inspiration - Staff

www.expeditioninspiration.org [cached]

Angela DeMichele, MD, MSCE Angela DeMichele, MD, MSCE, has been our Expedition Inspiration Medical Advisory Committee chair since 2009 and became involved with Expedition Inspiration in 2003.

Dr. DeMichele is an Associate Professor of Medicine and Epidemiology at the University of Pennsylvania and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics. She co-leads the Breast Cancer Research Program of the Abramson Cancer Center and directs the Doris Duke Clinical Research Fellowship Program at the University of Pennsylvania.
Dr. DeMichele earned a B.S. in Biochemistry from Brown University, an M.D. from Washington University School of Medicine (as a Four Schools Physician/Scientist Scholar) and a Masters Degree in Clinical Epidemiology from the University of Pennsylvania. She received her clinical training in Internal Medicine and Hematology/Oncology at the University of Pennsylvania, and joined the faculty in 2000 as a breast cancer oncologist and molecular epidemiologist whose research focuses on identifying markers of outcome, response to therapy and development of targeted therapeutics.
She is currently the PI of numerous clinical trials and epidemiologic studies, including Chair of Trial Operations for the I-SPY2 Trial, a multicenter clinical trial in which targeted therapeutics are tested in the context of molecular and MRI imaging response profiles in patients receiving neoadjuvant therapy for locally-advanced breast cancer, and her work has been funded through the NCI and other charitable foundations.
In addition, she directs Penn's Breast Cancer Survivorship Program, a multidisciplinary clinical research program at the Abramson Cancer Center, where she and her colleagues are performing studies of bone loss, ovarian dysfunction, hot flashes, lymphedema, depression/distress and physical activity in breast cancer survivors.
She is a past recipient of a Young Investigator Award from the American Society of Clinical Oncology, a Clinical Research Training Grant from the American Cancer Society and a Patient-Oriented Career Development Award from the NIH. Dr. DeMichele has served on the American Board of Internal Medicine Oncology Subspecialty Board, the Editorial Board of the Journal of Clinical Oncology and is currently Chair of the Medical Advisory Board of the Expedition Inspiration Fund for Breast Cancer Research. + Expand

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