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Wrong Alice Gottlieb?

Dr. Alice Bendix Gottlieb

Chair of Dermatology and Dermatologist-in-Chief Harvey B. Ansell Professor

Dermatology Foundation

HQ Phone: (847) 328-2256

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Dermatology Foundation

1560 Sherman Avenue Suite 500

Evanston, Illinois 60201

United States

Company Description

The Dermatology Foundation is a nonprofit organization created in 1964 by concerned dermatologists to provide a national organization for advancing patient care through funded research, and is now second only to the federal government as a source of fundi ... more

Find other employees at this company (44)

Background Information

Employment History

PhD

Professor of Dermatology

New York Medical College

Professor of Medicine

UMDNJ-Robert Wood Johnson Medical School

Harvey B. Ansell Professor of Dermatology

Tufts Medical Center

Affiliations

Board Member
IDEOM

Member
Noah Worcester Dermatological Society Foundation

Member
American Dermatological Association , Inc.

Board Member
Women's Dermatologic Society

Member, Editorial Boards
Journal of the American Academy of Dermatology

Member of the Medical Advisory Board
American Academy of Dermatology

Advisory Board Member
ODAC

Councilor
International Psoriasis Council

Advisor
Abbott Laboratories company

Board Member
NetOn-Line Services

Active Member
Clinical Immunology Society

Active Member
National Eczema Association

Active Member
American Academy of Pharmaceutical Physicians

Active Member
American College of Rheumatology

Active Member
Society for Investigative Dermatology

Member, Editorial Boards
Journal of Cutaneous Medicine and Surgery

Member, Scientific Advisory Board
NEA

Investigator, Consultant, and Speaker Bureau Member
Biogen Idec Inc.

Investigator, Consultant, and Speaker Bureau Member
Centocor , Inc.

Investigator, Consultant, and Speaker Bureau Member
Wyeth

Investigator, Consultant, and Speaker Bureau Member
Amgen Inc.

Investigator, Consultant, and Speaker Bureau Member
Novartis AG

Member
Steering Committee of GRAPPA

Member, Editorial Advisory Board
Skin Inc

Medical Board Member
National Psoriasis Foundation Incorporated

Clinical Advisory Board Member
Convoy Therapeutics Inc

Medical Board Member
Psoriasis Foundation

Board Member
JointandBone.org

Member of Scientific and Clinical Advisory Board
IDEC Pharmaceuticals Corporation

Founder
International Dermatology Outcomes Measures consortium

Education

Cornell Medical School

UMDNJ-Robert Wood Johnson Medical School

M.D.

Tufts University , Boston

MD

American College of Clinical Pharmacology Honorary Fellowship Award

MD

American College of Rheumatology

MD

Cornell Medical School

MD

Tufts University

doctorate

immunology

Rockefeller University

doctorate in philosophy

immunology

The Rockefeller University

medical degree

Cornell University

medical degree

Cornell University Medical College

medical degree

The Cornell University Medical College

medical degree

Weill Cornell Medical College

Web References (181 Total References)


International Dermatology Outcome Measurers

dermoutcomes.org [cached]

Chair - Alice Gottlieb, MD, PhD

...
Alice Gottlieb, MD, PhD Professor of Dermatology New York Medical College
...
Dr. Gottlieb is a Professor of Dermatology at New York Medical College. Dr. Gottlieb is an internationally recognized leader in psoriasis and psoriatic arthritis research. She is an expert in the concept of psoriasis as an immune mediated disease and the treatment of the disease with targeted immunotherapies. She is board certified in Dermatology, Rheumatology and Internal Medicine.


Introduction to Psoriasis - A detailed overview of psoriasis, including treatments and causes of the skin disorder.

www.understandingpsoriasis.com [cached]

Alice Bendix Gottlieb, MD, PhD UMDNJ-Robert Wood Johnson Medical School

Alice Bendix Gottlieb, MD, PhD, a board certified specialist in internal medicine, rheumatology, and dermatology, is the WH Conzen Chair in Clinical Pharmacology at the University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School in New Brunswick.She is Director of the Clinical Research Center at UMDNJ-Robert Wood Johnson Medical School, Professor of Medicine, and Associate Chair for Research in the Department of Medicine.
Dr. Gottlieb received her medical degree from The Cornell University Medical College and a doctorate in philosophy in immunology from The Rockefeller University in New York.She completed medical and dermatologic residencies at The New York Hospital and a fellowship in rheumatic diseases at The Hospital for Special Surgery, both in New York City.
Widely published in such journals as The Lancet, Journal of the American Academy of Dermatology, Journal of Cutaneous Medical Surgery, and Cutis, Dr. Gottlieb also serves on the editorial boards of the Journal of the American Academy of Dermatology, the Journal of Cutaneous Medicine and Surgery, and the Journal of the European Academy of Dermatology and Venereology.She is also Dermatology Section Editor for Clinical Immunology.Dr. Gottlieb is a journal reviewer for The New England Journal of Medicine, The Lancet, The Journal of Investigative Dermatology, the Journal of the American Academy of Dermatology, and Archives of Dermatology.Her work on biotechnological treatments for psoriasis was featured in The New York Times.She has also been featured in the Wall Street Journal, The San Francisco Chronicle, and Barron's.
Dr. Gottlieb is an active member of several professional societies, including the American Academy of Dermatology, Society of Investigative Dermatology, Noah Worcester Dermatology Society, American College of Rheumatology, American Academy of Pharmaceutical Physicians, National Eczema Association (NEA), National Psoriasis Foundation (NPF), Women's Dermatologic Society (member of the Board of Directors), and the Clinical Immunology Society.She is a member of the medical advisory board of the NPF and the psoriasis task force of the American Academy of Dermatology.She also serves on the Scientific Advisory Board of the NEA.


DermatologyTimes - Psoriasis Drug MIA

www.dermatologytimes.com [cached]

Dr. Gottlieb

San Francisco - The anti-CD40 ligand monoclonal antibody IDEC-131, manufactured by IDEC Pharmaceuticals, was developed to treat autoimmune and inflammatory diseases, such as psoriasis.IDEC-131 targets the CD40 ligand on T cells and regulates the interaction between T cells and B cells.
When p154 interacts with CD40, there is an upregulation of costimulatory molecules, according to Alice B. Gottlieb, M.D., Ph.D.This leads to activation of Langerhans cells and promotes differentiation of cytotoxic T cells (CD8+ cells)."All these things could play a role in psoriasis development," said Dr. Gottlieb, director, Clinical Research Center, and professor of medicine, UMDNJ-Robert Wood Johnson Medical School.
IDEC-131 may help to restore a normal immune response in psoriasis patients.The results of a study on IDEC-131 were summarized in a poster Dr. Gottlieb presented at the annual meeting of the American Academy of Dermatology.
The study was a multicenter, open-label, multiple dose, dose-escalating clinical trial.The primary objectives of the trial were to assess the safety of IDEC-131 and to obtain pharmacodynamic and pharmacokinetic data.Efficacy data also were obtained.
Novel Antigen Examined > "One of the pharmacodynamic points was to assess the effect of IDEC-131 on the humoral immune response to a novel antigen," added Dr. Gottlieb.Keyhole limpet hemocyanin, or KLH, was chosen to be this novel antigen because it is a protein that people are not usually immunized to and can be used in patients safely, she said.KLH is obtained from a giant mollusk.
...
"There were no infusion-related symptoms, no detectable anti-IDEC-131 response, and no treatment-related lymphocyte depletion," Dr. Gottlieb said.Adverse events were mild to moderate in severity.Some of the most common adverse events were upper respiratory tract infection, headache, and nausea.According to Dr. Gottlieb, the incidence and severity of adverse events was not dose-related.
In terms of efficacy, 15 percent (or four) of the subjects had 50 percent or greater reduction in plaques from day 5 to day 92, 48 percent (or 13) of the subjects achieved a 50 percent or greater reduction in plaques at some point in the study, and 7 percent (or two) of the subjects had a 75 percent or greater reduction in plaques.In those subjects who responded well, biopsies showed a very nice reduction in T cell numbers, thinning of the epidermis, and normalization of keratin."In patients who responded, they responded very well," Dr. Gottlieb said.
Presumably based upon the low efficacy and the fact that Amevive is now approved for use in psoriasis, IDEC Pharmaceuticals decided to not pursue IDEC-131 any further."There was activity ... but the results were not impressive enough considering we have approved drugs to use already," Dr. Gottlieb said.
Dr. Gottlieb is a member of the advisory board for IDEC pharmaceuticals.She has no stock holdings.


Supplement, Nov 1, 2002

www.dermatologytimes.com [cached]

Physician: Alice Gottlieb, M.D., Ph.D.

Efalizumab Lifts Quality of Life in Just Two Weeks


International Dermatology Outcome Measurers | IIDEOM is an international non-profit organization seeking to develop & validate outcome measures throughout dermatology with an initial focus on psoriasis.

dermoutcomes.org [cached]

Alice Gottlieb, MD, PhD, President

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