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Wrong Alfredo Galvez?

Alfredo F. Galvez

Project Scientist

The-Center-of-Excellence-for-Nutritional-Genomics

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Background Information

Employment History

//www.lunasin.com/


Chief Scientific Officer

Missouri Plant Science Center


Director of Research

Missouri Plant Science Center


Adjunct Assistant Professor

University of Missouri


Research Geneticist

USDA


Postdoctoral Researcher

University of California


Affiliations

Soy Labs LLC

Lead Scientific Advisor


SL Technology , Inc.

Chief Scientific Officer


UC Davis

Center Scientist (Collaborator)


Missouri Plant Science Center

Lead Scientific Advisor


The MPSC

Lead Scientific Advisor


Mexico Public Schools

Lead Scientific Advisor


MPSC’s

Lead Scientific Advisor


Education

B.S.

Genetics and Plant Physiology

University of the Philippines at Los Banos


M.S. degrees

Genetics and Plant Physiology

University of the Philippines at Los Banos


Ph.D.

University of California at Davis Center of Excellence for Nutritional Genomics & University of Missouri at Columbia


Ph.D.

Washington State University


Ph.D.

Genetics

University of California , Davis


PhD

Genetics and Molecular Biology

UC Davis


doctorate

genetics

University of California Davis


Web References(51 Total References)


Lunasin - Lunasin Researchers

lunasin.com [cached]

Alfredo F. Galvez, Ph.D.
Project Scientist, Center of Excellence for Nutritional Genomics, University of California, Davis, CA Chief Scientific Officer, SL Technology, Inc., Chesterfield, MO Alfredo F. Galvez, Ph.D. is currently the Chief Scientific Officer of SL Tech, Inc., a Reliv subsidiary company, working on the development of functional foods and nutraceutical ingredients based on the lunasin peptide, a soy protein component he serendipitously discovered in 1996 as a postdoctoral researcher at UC Berkeley. He has a PhD in Genetics from UC Davis, majoring in molecular biology and cytogenetics. He is also a Project Scientist at the Center for Nutritional Genomics, University of California at Davis, working on elucidating the molecular mechanism of lunasin as a peptidomimetic of a human tumor suppressor. Dr. Galvez earned his B.S. and M.S. degrees in Genetics and Plant Physiology from the University of the Philippines at Los Banos, and his Ph.D. in Genetics from the University of California, Davis. After completing his Ph.D., Dr. Galvez worked for the USDA-ARS at Washington State University and at the University of California Berkeley as a Research Biochemist and Geneticist.


December 2013 Newsletter | Filipino Community Center

filcom.org [cached]

Dr. Alfredo Galvez
Dr. Alfredo Galvez, a graduate of the University of the Philippines in Los Banos, will be conducting another freeseminar on December 14, Saturday at 9:30 a.m. at the FilCom Center in Waipahu to reprise a workshop he conducted last September. He will discuss again the potentially life-altering effects of Lunasin and its effects on cancer as well as other serious health issues. Dr. Galvez grew up in La Union, Philippines with an inherent love for science and a built-in desire to experiment with plants. Galvez graduated from the UP Los Banos with a Masters in Genetics and Plant Breeding. He received a scholarship to UC Davis where he pursued his PhD in Genetics and Molecular Biology. He went on to become a Research Geneticist at the USDA in Washington State University where he had been for two years when a colleague from UP Los Banos asked his help in gene cloning at UC Berkeley. After joining their staff a serendipitous discovery was made. As an accidental by-product of their cloning work, Lunasin was discovered. Lunasin is an extraordinary plant peptide that has been shown to disrupt cancer cell division and prevent tumor formation. Galvez and his colleagues named it Lunasin which is the Tagalog word for "heal" or "remedy". Dr. Galvez is proving that this is not true. Though we cannot change our DNA, Lunasin has the ability to essentially turn "off" the bad genes and turn "on" the good genes in our bodies. This is a game changer in the area of disease control as well as many other areas. In his research, Dr. Galvez realized that this impressive natural peptide, found in miniscule quantities in soybeans, blocks cell division and effectively turns down the dimmer switch in our genetic material. In other words, it makes cells less receptive to disease. This mechanism has been included in prestigious journals such as theJournal of Cancer Research. Further, a recent analysis in Cancer Metastasis Reviews noted that lunasin has been shown to be active against human breast cancer, colon cancer, and leukemia cells in the laboratory. In a mouse study, injection of lunasin into mice implanted with human breast cancer cells reduced tumor incidence by 33 to 49 percent. Dr. Galvez also discovered that it is not Lunasin alone that refocuses our genetic material. He is making history because he developed a means of protecting the peptide so that sufficient amounts could be absorbed once inside the body. "I have been excited for years about the enormous potential of the Lunasin peptide, says Galvez, but it's the bioactive Lunasin, that has opened the door to a broad range of dramatic health benefits and I am helping the world with affordable solutions." Dr. Galvez is presently a Research Scientist at the Center of Excellence for Nutritional Genomics, UC Davis, California. He is also the Director of Research for the Missouri Plant Science Center, Mexico, MO.


Scientist Bios

www.lunasin.com [cached]

Dr. Alfredo Galvez's presentation abstract was selected for publication in
the prestigious AHA Journal, Circulation! View the abstract here. Alfredo F. Galvez, Ph.D Center Scientist, Center of Excellence for Nutritional Genomics, University of California, Davis, CA Dr. Alfredo Galvez joined the Center of Excellence in Nutritional Genomics six years ago to work on elucidating the molecular mechanism of action of the soy peptide, lunasin. Dr. Galvez serendipitously discovered the anti-cancer properties of the lunasin peptide, while working as a postdoctoral researcher on a project to increase the methionine content of soy protein at UC Berkeley in the late 1990's. His work led to the novel finding that lunasin binds specifically to deacetylated histones H3 and H4 and prevents their acetylation via a masking effect. Inhibitors of histone acetylation are correlated with gene repression, however microarray analysis of prostate cells treated with lunasin under basal condition showed that this soy peptide upregulates expression of chemopreventive genes but only in the non-tumorigenic cell line. The current working model to explain the microarray results is that lunasin preferentially binds to deacetylated lysine 8 in histone H4 and increases acetylation of H4-lysine 16, leading to increased gene expression. Dr. Galvez continues to work with the University of Missouri to further demonstrate Lunasin's effect on LDL cholesterol. This is based on his discovery that lunasin can inhibit the acetylation of histone H3 by the PCAF histone acetylase enzyme and reduce expression of HMG-CoA reductase (the rate-limiting enzyme for cholesterol biosynthesis) in liver cells. Chromatin immunoprecipitation (ChIP) have shown that SREBP transcriptional activation of HMG-CoA reductase requires H3 acetylation by PCAF. This discovery provides a mechanism of action to explain the cholesterol-lowering effects of soy protein and paves the way for optimizing soy protein ingredients to maximize its heart-healthy benefits. Prior to joining the Center, Dr. Galvez has founded and worked in a start-up biotech company. He obtained his Ph.D. in Genetics from UC Davis in 1992 and has worked as a research scientist for the USDA and UC Berkeley.


www.lunasin.com

Alfredo F. Galvez, Ph.D.
Alfredo F. Galvez, Ph.D. Center Scientist, Center of Excellence for Nutritional Genomics, University of California, Davis, CA Adjunct Assistant Professor, University of Missouri, Columbia, MO Lead Scientific Advisor, Soy Labs, LLC, Fairfield, CA Dr. Alfredo Galvez joined the Center of Excellence in Nutritional Genomics two years ago to work on elucidating the molecular mechanism of action of the soy peptide, lunasin. Dr. Galvez serendipitously discovered the anti-cancer properties of the lunasin peptide, while working as a postdoctoral researcher on a project to increase the methionine content of soy protein at UC Berkeley in the late 1990's. His work led to the novel finding that lunasin binds specifically to deacetylated histones H3 and H4 and prevents their acetylation via a masking effect. Inhibitors of histone acetylation are correlated with gene repression, however microarray analysis of prostate cells treated with lunasin under basal condition showed that this soy peptide upregulates expression of chemopreventive genes but only in the non-tumorigenic cell line. The current working model to explain the microarray results is that lunasin preferrentially binds to deacetylated lysine 8 in histone H4 and increases acetylation of H4-lysine 16, leading to increased gene expression. Dr. Galvez is also collaborating with the Missouri Soybean Board, Soy Labs and the University of Missouri to develop cholesterol-lowering soy protein extracts for commercial production. This is based on his discovery that lunasin can inhibit the acetylation of histone H3 by the PCAF histone acetylase enzyme and reduce expression of HMG-CoA reductase (the rate-limiting enzyme for cholesterol biosynthesis) in liver cells. Chromatin immunoprecipitation (ChIP) have shown that SREBP transcriptional activation of HMG-CoA reductase requires H3 acetylation by PCAF. This discovery provides a mechanism of action to explain the cholesterol-lowering effects of soy protein and paves the way for optimizing soy protein ingredients to maximize its heart-healthy benefits. Prior to joining the Center, Dr. Galvez has founded and worked in a start-up biotech company. He obtained his Ph.D. in Genetics from UC Davis in 1992 and has worked as a research scientist for the USDA and UC Berkeley. Galvez, A.F. , Chen N., Macasieb J. and B.O. de Lumen. Galvez, A.F. and B.O. de Lumen.


www.gnhealth.com

One of these researchers is Alfredo F. Galvez, Ph.D., a lead scientist at the Center of Excellence for Nutritional Genomics, University of California, Davis.


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