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Wrong Alan Howe?

Alan K. Howe

Associate Professor of Pharmacology

University of Vermont

HQ Phone:  (802) 847-0000

Direct Phone: (802) ***-****direct phone

Email: a***@***.edu

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I agree to the Terms of Service and Privacy Policy. I understand that I will receive a subscription to ZoomInfo Community Edition at no charge in exchange for downloading and installing the ZoomInfo Contact Contributor utility which, among other features, involves sharing my business contacts as well as headers and signature blocks from emails that I receive.

University of Vermont

322 South Prospect Street

Burlington, Vermont,05401

United States

Company Description

We are the tertiary referral center for Vermont, areas of New Hampshire, and upstate New York. Our patients represent the entire range of socioeconomic diversity and we serve large refugee populations from Africa, Eastern Europe, Southeast Asia, and the Balkan...more

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Background Information

Employment History

University of Vermont College of Medicine


University of Cincinnati


Affiliations

Gordon Research Conferences incorporated

Board of Trustees Member


Rollin' & Tumblin

Strat List Member Alan Howe


University of North Carolina at Chapel Hill

Postdoctoral Fellow


Education

Ph.D.

Tumor Cell Biology

Northwestern University


Web References(27 Total References)


Gordon Research Conferences - 2010 Program (Signaling by Adhesion Receptors)

www.grc.org [cached]

Alan Howe (University of Vermont)


HIGHLIGHTS from MBoC - ASCB

www.ascb.org [cached]

Brian Cunniff, Andrew J. McKenzie, Nicholas H. Heintz, and Alan K. Howe
Cell migration involves complex coordination of localized biochemical processes, many of which are energy-expensive. Shown is a color-coded image of mitochondrial flux in an ovarian cancer cell expressing a fluorescent mitochondrial marker as the cell migrates through a three-dimensional extracellular matrix. To make the image, each frame of a time-lapse live-cell movie was assigned a different hue on the color spectrum from indigo (first time point) to red (last time point), and these images were overlaid to illustrate the infiltration of mitochondria into the invasive leading edge. Cunniff, McKenzie, et al. (Mol. Biol. Cell 27, 2662-2674) detail this mitochondrial flux and show that it is controlled by localized activation of a signaling pathway that senses subcellular changes in energy status. These observations couple localized cellular energy demand to the subcellular targeting of mitochondria during cell movement. (Image: Alan K. Howe, University of Vermont) These observations couple localized cellular energy demand to the subcellular targeting of mitochondria during cell movement. (Image: Alan K. Howe, University of Vermont)


Vermont Cancer Center - 2010 VCC-LCCRO Pilot Project Awards Announced

www.vermontcancer.org [cached]

Alan Howe, Ph.D., UVM associate professor of pharmacology, will develop a new method to study tumor cells to help better understand the cell signaling networks influencing cancer's development and progression.
His study, entitled "Intermolecular Epitope Antibodies for Visualizing Subcellular Protein Complexes" will involve a unique approach for identifying cancer-related interactions between proteins. Proteins typically do not work alone, but rather in multi-protein complexes. Often, changes in these complexes occur during cancer development and progression. Scientists presently have many tools for studying individual proteins in cells, but very few for studying intact protein complexes. Dr. Howe's project will focus on a new approach for identifying antibodies that only recognize protein complexes, rather than individual proteins - a technology that will enable scientists to examine the formation and location of protein complexes involved in cancer cells.


Vermont Cancer Center - Home

www.vermontcancer.org [cached]

Alan Howe, Ph.D., UVM associate professor of pharmacology, will be developing "Intermolecular Epitope Antibodies for Visualizing Subcellular Protein Complexes.
His work will involve the development of a novel approach for determining the subcellular localization of specific, endogenous protein-protein complexes. Howe will focus on those antibodies that reflect alterations in the tumor microenvironment in order to facilitate a better understanding of signaling networks that influence the development and progression of cancer.


Molecular Signaling 1 Peer Review Committee

www.americanheart.org [cached]

Alan K. Howe, Ph.D.Assistant ProfessorUniversity of Vermont, Burlington


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